Results 211 to 220 of about 101,155 (265)

Bacterial expression of immunoglobulin fragments

Current Opinion in Immunology, 1993
The expression of Ig fragments in Escherichia coli permits rapid access to engineered molecules with antigen-binding properties. While the expression in a functional state by secretion to the periplasm is the standard method for the production of Fv and Fab fragments, single chain Fv fragments are mainly produced by refolding from insoluble aggregates.
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Characterization of immunoglobulin G fragments in liquid intravenous immunoglobulin products

Transfusion, 2005
BACKGROUND: Intravenous immunoglobulin (IVIG) products formulated as a liquid instead of a powder have become commercially available. Preferably, such liquid products should not alter after storage outside the refrigerator. Therefore, a thorough characterization of immunoglobulin G (IgG) fragmentation at various storage temperatures is required.STUDY ...
Robert V, Diemel, Hendricus G J, ter Hart, Gerardus J A, Derksen, Anky H L, Koenderman, Rob C, Aalberse   +4 more
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Inhibition or acceleration of fibrin polymerization by monoclonal immunoglobulins and immunoglobulin fragments

Thrombosis Research, 1984
A prolongation of the thrombin clotting time by at least 25% was found in the presence of 8 of 26 IgG myeloma proteins, 2 of 5 IgA proteins and 1 of 10 macroglobulins, in a concentration of 10 mg/ml. Normal pooled immunoglobulin in concentrations up to 83 mg/ml were inactive.
F, Wisløff, T E, Michaelsen, H C, Godal
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The Relative Rate of Immunoglobulin Gamma 1 Fragmentation

Journal of Pharmaceutical Sciences, 2011
The physicochemical stability of protein therapeutics is of significant pharmaceutical interest. Immunoglobulin gamma (IgG) hinge region fragmentation has recently garnered attention as an important degradation route of therapeutic monoclonal antibodies.
Tim J, Kamerzell, Megan, Li, Shaily, Arora, Junyan A, Ji, Y John, Wang   +4 more
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Allotypic Markers on Fab Fragments of Mouse Immunoglobulins

The Journal of Immunology, 1974
Abstract Allotypic determinants were detected on the Fab fragments of mouse IgG by guinea pig antisera prepared against polymerized Fab fragments of IgG from the C57BL and AKR strains. Different markers were detected by the two antisera. Indirect precipitation, with 125I-labeled Fab as ligand, was used for the assay.
Spring, S B, Nisonoff, A
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Interaction of immunoglobulin fragments with the mammalian sperm acrosome

Journal of Experimental Zoology, 1978
AbstractA study was made of the interaction of immunoglobulins and immunoglobulin fragments from sera of rabbits and pigs with the acrosomes of ten species of mammalian spermatozoa to investigate previous reports of an interaction between normal serum and the acrosome.
G J, Allen, F J, Bourne
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Immunoglobulin Fab fragment-binding proteins

International Journal of Immunopharmacology, 1994
Five molecules are known to bind the Fab fragments of human immunoglobulins (Ig). Microbial protein A and protein G are primarily Fc-binding molecules but can also bind other structures of the heavy chain, which are located in the variable domain of the third subgroup (VH3) and in the first constant domain of IgG (CH1 gamma), respectively. In contrast,
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New biologically active fragments of immunoglobulins

Survey of Immunologic Research, 1985
Abstract We developed a working hypothesis and relevant models based on it, which can be applied to investigations of immunoregulatory processes. Oligopeptides effecting signalling functions (activators or supressors of lymphocytes, macrophages, and other immune system cells) are postulated to emerge from protein precursors by limited proteolytic ...
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Crystallographic Data for the Fab Fragment of a Human Myeloma Immunoglobulin

Nature, 1968
COMPARISONS of the physical properties and chemical structure of myeloma proteins with those of other immunoglobulins and antibodies have indicated that myeloma proteins are abnormal only in their relative homogeneity; they seem to be typical representatives of the immunoglobulin class to which they belong. In addition, antibody activity has been shown
AVEY H. P, POLJAK R. J, ROSSI, GUIDO, NISONOFF A.   +3 more
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Studies on Fd Fragments of Human Immunoglobulins

Scandinavian Journal of Immunology, 1975
Earlier studies on antisera against Fab of pooled human IgG and IgA myeloma proteins disclosed the presence of class‐specific Fd antibodies, the demonstration of which required interaction of heavy and light chains. To extend our knowledge about the antigenic structure of the Fd fragment of human immunoglobulins, antisera were prepared in rabbits ...
B. J. M. ZEGERS, R. E. BALLIEUX, E. VAN LOGHEM   +2 more
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