Results 191 to 200 of about 101,155 (265)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Stage-Dependent Transcriptional Reprogramming of B-Cell Receptor Signaling and Antigen Presentation During Bovine Leukemia Virus-Driven Lymphomagenesis. [PDF]

Anim Genet
Akbarin MM, Farjami Z, Murillo CR, González-Fernández VD, Acevedo-Jiménez GE, de María Ávila-De la Vega L, Álvarez HR.   +6 more
europepmc   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Unlabeled NMR Approach with Site-Specific Methyl Assignments for Structural Evaluation of the IgG1 Fc Region. [PDF]

J Am Chem Soc
Yanaka S, Koseki Y, Miyanoiri Y, Yamazaki T, Terauchi T, Kaneko D, Isono Y, Tomita K, Kondo S, Onitsuka M, Yagi-Utsumi M, Yagi H, Ishii-Watabe A, Kato K.   +13 more
europepmc   +1 more source

Surface Neuronal‐Like Structuring of High‐Strength CFRP for Enhanced Electromagnetic Interference Shielding

Advanced Science, EarlyView.
This study elucidates the microstructural evolution at the material interface of Ni‐plated plain‐weave carbon fiber fabric following vacuum heat treatment at 500°C–900°C under different current densities, as well as the mechanism underlying the synergistic enhancement of electromagnetic shielding and ductility.
Wei Cheng, Ben Jia, Shuhan Xiang, Biao Chen, Yongjun Zhang, Zhuo Liu, Xiaopeng Wan, Heyuan Huang   +7 more
wiley   +1 more source

Analysis of CDR3 region diversity with different lengths in bovine immunoglobulin heavy chain genes. [PDF]

Front Immunol
Zhao H, Tang X, Zhang Y, Wu M.
europepmc   +1 more source

The Emerging Roles of GlycoRNAs in the Pathogenesis of Sepsis. [PDF]

Cells
Li X, Nallajennugari S, Fu J, Faisal A, Fu M.   +4 more
europepmc   +1 more source

Extending Serum IgG1 Antibody Repertoire Coverage Using DIA-PTCR. [PDF]

J Am Soc Mass Spectrom
Leuvenink RW, Wollenweber L, Bondt A, Fort KL, Heck AJR.   +4 more
europepmc   +1 more source

Successful 6-year follow-up of treatment for IgA nephropathy complicated by IgA-λ monoclonal gammopathy with multi-system damage: a case report. [PDF]

Front Immunol
Li Y, Li X, Lu Y, Huang M.
europepmc   +1 more source

Humoral immune responses to hyaluronan oligosaccharides in patients undergoing prosthetic valve surgery. [PDF]

Front Immunol
Bello-Gil D, Olivera-Ardid S, Blasco-Lucas A, Sbraga F, Galiñanes M, Le Tourneau T, Roussel JC, Bottio T, Vadori M, Cozzi E, Galli C, Costa C, Padler-Karavani V, Soulillou JP, Mañez R.   +14 more
europepmc   +1 more source