Results 1 to 10 of about 16,771 (215)

Genomic characterization of the T-cell receptor loci in Ambystoma mexicanum [PDF]

Frontiers in Immunology
BackgroundAmphibians are valuable models for comparative immunology. In the caudate Ambystoma mexicanum, the architecture of immunoglobulin loci resembles that of the anuran Xenopus tropicalis, although some antibody gene features are absent.
Diana L. Pacheco-Olvera, Diana L. Pacheco-Olvera, Stephanie Saint Remy-Hernández, Stephanie Saint Remy-Hernández, E. Ernestina Godoy-Lozano, Juan Téllez-Sosa, Humberto Valdovinos-Torres, Everado Curiel-Quesada, Constantino López-Macías, Jesus Martínez-Barnetche   +9 more
doaj   +2 more sources

Diagnosing a Challenging Case of Primary Amyloidosis using Capillary Electrophoresis [PDF]

National Journal of Laboratory Medicine, 2021
Amyloid Light chain (AL) amyloidosis is characterised by deposition of intact free light chains or their fragments in extracellular space. Here, authors describe the journey of a diagnostically challenging patient who presented with features of ...
rashmi verma, rajni saijpaul, Surbhi Garg, niharika jain, Vineeta V Batra   +4 more
doaj   +1 more source

Pattern of serum immunoglobulins and free light chain levels among patients diagnosed with multiple myeloma in Southeast Nigeria

International Journal of Medicine and Health Development, 2023
Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi, Anazoeze J Madu, Ifeoma C Ajuba, Sunday Ocheni, Gladys U Ilechukwu, Nnenna Ogbodo, Oji A Nnachi   +6 more
doaj   +1 more source

Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction [PDF]

PeerJ, 2020
Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface.
Akhila Melarkode Vattekatte, Nicolas Ken Shinada, Tarun J. Narwani, Floriane Noël, Olivier Bertrand, Jean-Philippe Meyniel, Alain Malpertuy, Jean-Christophe Gelly, Frédéric Cadet, Alexandre G. de Brevern   +9 more
doaj   +2 more sources

Immune subtraction for improved resolution in serum protein immunofixation electrophoresis and antibody isotype determination in a patient with autoantibody

Practical Laboratory Medicine, 2021
Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah, Nivin Omar, Natasha M. Savage, Roni J. Bollag, Gurmukh Singh   +4 more
doaj   +1 more source

A Case of Primary Amyloidosis Involving Liver, Stomach, Intestines, and Heart without Evident Kidney Involvement

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022
Aim. Systemic amyloidosis caused by the synthesis and deposition of immunoglobulin light chains (AL amyloidosis) is a relatively rare disease that involves heart, kidneys, peripheral nervous system, gastrointestinal tract, and has a large number of ...
L. S. Kholopov, N. B. Gubegrits, O. A. Dyadyk, Yu. E. Chirkov, Yu. V. Tsohoyeva   +4 more
doaj   +1 more source

Tailor-making a protein a-derived domain for efficient site-specific photocoupling to Fc of mouse IgG₁. [PDF]

PLoS ONE, 2013
Affinity proteins binding to antibody constant regions have proved to be invaluable tools in biotechnology. Here, protein engineering was used to expand the repertoire of available immunoglobulin binding proteins via improvement of the binding strength ...
Feifan Yu, Peter Järver, Per-Åke Nygren   +2 more
doaj   +1 more source

Discordance of light chain isotypes between serum and glomerular deposits in proliferative glomerulonephritis with monoclonal IgG deposits: a case report and review of the literature

BMC Nephrology, 2023
Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a disease entity with nonorganized granular glomerular deposition with monoclonal proteins of both heavy and light chains. Dysproteinemia was observed
Shoko Miura, Kan Katayama, Yuka Sugimoto, Fumika Tanaka, Mutsuki Mori, Daisuke Takahashi, Ryosuke Saiki, Yosuke Hirabayashi, Tomohiro Murata, Isao Tawara, Kaoru Dohi   +10 more
doaj   +1 more source

Changes in Serum and Salivary Proteins in Canine Mammary Tumors

Animals, 2020
The aim of this study was to evaluate changes in serum and saliva proteomes in canine mammary tumors (CMT) using a high-throughput quantitative proteomic analysis in order to potentially discover possible biomarkers of this disease.
Lorena Franco-Martínez, Andrea Gelemanović, Anita Horvatić, María Dolores Contreras-Aguilar, Roman Dąbrowski, Vladimir Mrljak, José Joaquín Cerón, Silvia Martínez-Subiela, Asta Tvarijonaviciute   +8 more
doaj   +1 more source

Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica

BMC Genomics, 2008
Background All jawed-vertebrates have four T cell receptor (TCR) chains: alpha (TRA), beta (TRB), gamma (TRG) and delta (TRD). Marsupials appear unique by having an additional TCR: mu (TRM).
Sharp Alana, Trujillo Jonathan, Lopez April M, Hathaway Jennifer, Baker Michelle L, Parra Zuly E, Miller Robert D   +6 more
doaj   +1 more source