Results 1 to 10 of about 218 (190)
Diagnosing a Challenging Case of Primary Amyloidosis using Capillary Electrophoresis [PDF]
National Journal of Laboratory Medicine, 2021 Amyloid Light chain (AL) amyloidosis is characterised by deposition of intact free light chains or their fragments in extracellular space. Here, authors describe the journey of a diagnostically challenging patient who presented with features of ...
rashmi verma +4 more
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International Journal of Medicine and Health Development, 2023 Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi +6 more
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Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction [PDF]
PeerJ, 2020 Antigen binding by antibodies requires precise orientation of the complementarity- determining region (CDR) loops in the variable domain to establish the correct contact surface.
Akhila Melarkode Vattekatte +9 more
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Concerted evolution of the mouse immunoglobulin gamma chain genes. [PDF]
The EMBO Journal, 1984 The nucleotide sequences of the immunoglobulin heavy-chain constant region genes of mouse, C gamma 3, C gamma 1, C gamma 2b and C gamma 2a, together with that of a human equivalent C gamma 4 were compared. All the six pairs of genes within the mouse C gamma gene family contain DNA segments that exhibit marked homology, whereas no such segmental ...
Takashi Miyata +5 more
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Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains. [PDF]
Proceedings of the National Academy of Sciences, 1982 The nucleotide sequences of the exons encoding membrane-bound IgG1, IgG2a, and IgG2b of mouse were determined and compared with the sequence of membrane-bound IgM. The sequences indicate that membrane-bound gamma chains bear an additional 71 residues at the COOH termini, including 17-residue acidic, 26-residue hydrophobic, and 28 residue hydrophilic ...
Yuriko Yamawaki-Kataoka +3 more
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Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022 Aim. Systemic amyloidosis caused by the synthesis and deposition of immunoglobulin light chains (AL amyloidosis) is a relatively rare disease that involves heart, kidneys, peripheral nervous system, gastrointestinal tract, and has a large number of ...
L. S. Kholopov +4 more
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Tailor-making a protein a-derived domain for efficient site-specific photocoupling to Fc of mouse IgG₁. [PDF]
PLoS ONE, 2013 Affinity proteins binding to antibody constant regions have proved to be invaluable tools in biotechnology. Here, protein engineering was used to expand the repertoire of available immunoglobulin binding proteins via improvement of the binding strength ...
Feifan Yu +2 more
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BMC Nephrology, 2023 Background Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a disease entity with nonorganized granular glomerular deposition with monoclonal proteins of both heavy and light chains. Dysproteinemia was observed
Shoko Miura +10 more
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Changes in Serum and Salivary Proteins in Canine Mammary Tumors
Animals, 2020 The aim of this study was to evaluate changes in serum and saliva proteomes in canine mammary tumors (CMT) using a high-throughput quantitative proteomic analysis in order to potentially discover possible biomarkers of this disease.
Lorena Franco-Martínez +8 more
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Ultrastructural localization of gamma-chain and immunoglobulin G in human lymphocytes using enzyme-labeled Fab fragment. [PDF]
Journal of Histochemistry & Cytochemistry, 1975 By the use of rabbit antibodies against the heavy chain of human immunoglobulin G (IgG), the gamma-chain and IgG molecules were successfully localized at the ultrastructural level in human peripheral lymphocytes. The rabbit Fab fragment was coupled to horseradish peroxidase by means of glutaraldehyde and the resulting conjugate could penetrate the ...
J P Chen, C T Lin, J P Chang
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