Results 111 to 120 of about 218 (190)

Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets

open access: yesESC Heart Failure, EarlyView.
Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley   +1 more source

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

open access: yesSmall, Volume 18, Issue 51, December 22, 2022., 2022
Hyaluronic acid (HA) is a very promising polysaccharide for biomedical applications. This review provides a comprehensive overview of the development of nanoparticulate systems by HA‐based polyelectrolyte complexation. The main achievements and applications for the delivery of active substances or the construction of multifunctional platforms are ...
Huu Van Le, Didier Le Cerf
wiley   +1 more source

Enantioselective Anion‐Binding‐Catalyzed Nucleophilic Addition to 4‐Quinolones

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
Chiral quinolones and their derivatives are predominant synthetic building blocks and pharmacological agents. Nevertheless, their synthesis mostly relies on transition‐metal‐catalyzed enantioselective 1,4‐additions of organometallic reagents such as Grignard, organozinc or organoboron species for alkylation, arylation and alkynylation reactions. Herein,
Martin Aleksiev   +2 more
wiley   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

open access: yesElectrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Markers for internal neoplasia in the horse

open access: yesVeterinary Medicine and Science, Volume 9, Issue 1, Page 132-143, January 2023., 2023
The measurement of tumour markers in horses should be performed only in risk groups or in patients with suspicious clinical/laboratory findings (paraneoplastic syndromes). The results should be interpreted with caution as many factors (e.g., young age, pregnancy and inflammation) affect their concentration or activity.
Karolina Drozdzewska, Heidrun Gehlen
wiley   +1 more source

Veterinary nanomedicine: Pros and cons

open access: yesVeterinary Medicine and Science, Volume 9, Issue 1, Page 494-506, January 2023., 2023
Abstract In recent years, nanotechnology has improved life with continuous growth in different fields. Nanoparticles can be employed in industry, imaging, engineering, and various biomedical filed because of their special physicochemical properties like rapid, effective, highly specific solutions, higher stability, biodegradability, biocompatibility ...
Fariba Jafary   +2 more
wiley   +1 more source

Combined plasma levels of IL‐10 and testosterone, but not soluble HLA‐G5, predict the risk of death in COVID‐19 patients

open access: yesAndrology, Volume 11, Issue 1, Page 32-44, January 2023., 2023
Abstract Background The identification of biomarkers correlated with coronavirus disease 2019 (COVID‐19) outcomes is a relevant need for clinical management. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is characterized by elevated interleukin (IL)‐6, IL‐10, HLA‐G, and impaired testosterone production.
Giada Amodio   +21 more
wiley   +1 more source

Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling

open access: yesiMeta, EarlyView.
Compared to healthy controls, children with food‐sensitized tolerance and food allergy showed reduced fecal short‐chain fatty acids (SCFAs), particularly butyrate. In an ovalbumin‐sensitized mouse model, butyrate outperformed other SCFAs in alleviating allergic responses.
Jialu Shi   +11 more
wiley   +1 more source

Research progress of antibody coupling technique in targeted drug delivery

open access: yesInterdisciplinary Medicine, EarlyView.
Abstract Antibody‐drug conjugates are a cutting‐edge biotechnology recently attracting wide attention in the medical field. Binding antibodies to drug molecules could deliver drugs precisely to the site of the lesion, which shows great potential in the treatment of tumors and immune diseases.
Meng Li   +6 more
wiley   +1 more source

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