Results 11 to 20 of about 218 (190)

Functional Association between the Human Myeloid Immunoglobulin A Fc Receptor (CD89) and FcR γChain [PDF]

Journal of Biological Chemistry, 1995
FcR gamma chain has previously been shown to interact with the TCR-CD3 complex, the IgE Fc receptor I (Fc epsilon RI), and the class I and IIIA IgG receptors (Fc gamma RI and Fc gamma RIIIa). Here, we demonstrate that the Fc receptor gamma chain associates with Fc alpha R in transfected IIA1.6 B lymphocytes. Fc alpha R could be expressed at the surface
Alies Snijders, H. Craig Morton, Arthur J. Verhoeven, Paula J.M. Vossebeld, Ingrid E. van den Herik-Oudijk, Jan G. J. van de Winkel, Peter J.A. Capel   +6 more
openaire   +3 more sources

Human Immunoglobulin Heavy Gamma Chain Polymorphisms: Molecular Confirmation Of Proteomic Assessment

Molecular & Cellular Proteomics, 2017
Immunoglobulin G (IgG) proteins are known for the huge diversity of the variable domains of their heavy and light chains, aimed at protecting each individual against foreign antigens. The IgG also harbor specific polymorphism concentrated in the CH2 and CH3-CHS constant regions located on the Fc fragment of their heavy chains.
Marjorie Leduc, Célia Dechavanne, Célia Dechavanne, Joëlle Vinh, Chiara Giangrande, Florentin Aussenac, Florentin Aussenac, Jean-Michel Dugoujon, Alexandra Emmanuel, François Guillonneau, Magalie Dambrun, Magalie Dambrun, Florence Migot-Nabias, Florence Migot-Nabias, Marie-Paule Lefranc, Marie-Paule Lefranc   +15 more
openaire   +6 more sources

Comparative Proteomic Analysis of Serum from Pigs Experimentally Infected with Trichinella spiralis, Trichinella britovi, and Trichinella pseudospiralis

Pathogens, 2020
Although the available proteomic studies have made it possible to identify and characterize Trichinella stage-specific proteins reacting with infected host-specific antibodies, the vast majority of these studies do not provide any information about ...
Michał Gondek, Agnieszka Herosimczyk, Przemysław Knysz, Małgorzata Ożgo, Adam Lepczyński, Krzysztof Szkucik   +5 more
doaj   +1 more source

Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica

BMC Genomics, 2008
Background All jawed-vertebrates have four T cell receptor (TCR) chains: alpha (TRA), beta (TRB), gamma (TRG) and delta (TRD). Marsupials appear unique by having an additional TCR: mu (TRM).
Sharp Alana, Trujillo Jonathan, Lopez April M, Hathaway Jennifer, Baker Michelle L, Parra Zuly E, Miller Robert D   +6 more
doaj   +1 more source

Cutaneous T‐cell lymphomas: 2023 update on diagnosis, risk‐stratification, and management

American Journal of Hematology, Volume 98, Issue 1, Page 193-209, January 2023., 2023
Abstract Disease Overview Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). Diagnosis The diagnosis of MF or SS requires the integration of clinical and histopathologic data.
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source

Two Cases of Heavy Chain MGUS

Case Reports in Oncological Medicine, 2016
Heavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains. We describe two patients with asymptomatic heavy chain monoclonal gammopathy.
Jan Van Keer, Björn Meijers, Michel Delforge, Gregor Verhoef, Koen Poesen   +4 more
doaj   +1 more source

Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB

Frontiers in Immunology, 2020
The binding of immunoglobulin (Ig) to Fc gamma receptors (FcgR) at the immune cell surface is an important step to initiate immunological defense against malaria.
Abdou Khadre Dit Jadir Fall, Celia Dechavanne, Audrey Sabbagh, Evelyne Guitard, Jacqueline Milet, André Garcia, Jean-Michel Dugoujon, David Courtin, Florence Migot-Nabias   +8 more
doaj   +1 more source

Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]

Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020
Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv   +1 more source

mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain. [PDF]

Proceedings of the National Academy of Sciences, 1982
To probe the structure of the gamma heavy chain of membrane IgG and the mRNA and gene segments that encode it, we have analyzed cDNA clones derived from a gamma 1 membrane RNA of B lymphoma 2PK-3. The nucleotide sequence of the clones indicated that membrane gamma 1 chains bear a COOH-terminal 71-residue segment that is absent from secretory gamma 1 ...
Brett M. Tyler, S Gerondakis, Jerry M. Adams, Alan F. Cowman, Ora Bernard   +4 more
openaire   +3 more sources

Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies [PDF]

, 2021
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions of genomic material known as indels.
arxiv   +1 more source