Results 11 to 20 of about 16,771 (215)

Comparative Proteomic Analysis of Serum from Pigs Experimentally Infected with Trichinella spiralis, Trichinella britovi, and Trichinella pseudospiralis

Pathogens, 2020
Although the available proteomic studies have made it possible to identify and characterize Trichinella stage-specific proteins reacting with infected host-specific antibodies, the vast majority of these studies do not provide any information about ...
Michał Gondek, Agnieszka Herosimczyk, Przemysław Knysz, Małgorzata Ożgo, Adam Lepczyński, Krzysztof Szkucik   +5 more
doaj   +1 more source

Two Cases of Heavy Chain MGUS

Case Reports in Oncological Medicine, 2016
Heavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains. We describe two patients with asymptomatic heavy chain monoclonal gammopathy.
Jan Van Keer, Björn Meijers, Michel Delforge, Gregor Verhoef, Koen Poesen   +4 more
doaj   +1 more source

Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB

Frontiers in Immunology, 2020
The binding of immunoglobulin (Ig) to Fc gamma receptors (FcgR) at the immune cell surface is an important step to initiate immunological defense against malaria.
Abdou Khadre Dit Jadir Fall, Celia Dechavanne, Audrey Sabbagh, Evelyne Guitard, Jacqueline Milet, André Garcia, Jean-Michel Dugoujon, David Courtin, Florence Migot-Nabias   +8 more
doaj   +1 more source

A Case Report of Atypical Presentation of Multiple Myeloma on Serum Protein Electrophoresis [PDF]

Journal of Krishna Institute of Medical Sciences University, 2018
Multiple myeloma is a group of B-cell disorders resulting in the secretion of a specific and unique monoclonal immunoglobulin (M-protein). Protein electrophoresis is advised whenever multiple myeloma is suspected.
Pooja P. Padasal, Anil Malleshappa
doaj  

The Camel Adaptive Immune Receptors Repertoire as a Singular Example of Structural and Functional Genomics

Frontiers in Genetics, 2019
The adaptive immune receptors repertoire is highly plastic, with its ability to produce antigen-binding molecules and select those with high affinity for their antigen.
Salvatrice Ciccarese, Pamela A. Burger, Elena Ciani, Vito Castelli, Giovanna Linguiti, Martin Plasil, Martin Plasil, Serafina Massari, Petr Horin, Petr Horin, Rachele Antonacci   +10 more
doaj   +1 more source

Development of the PD9-9 Monoclonal Antibody for Identifying Porcine Bone Marrow-Derived Dendritic Cells

Life
The purpose of this study was to develop a monoclonal antibody (mAb) that can identify porcine dendritic cells (DCs) that have differentiated from bone marrow progenitor cells.
Sang Eun Kim, Young Kyu Kim, Keon Bong Oh, Jeong Ho Hwang   +3 more
doaj   +1 more source

The renal and hepatic distribution of Bence Jones proteins depends on glycosylation: a scintigraphic study in rats [PDF]

Brazilian Journal of Medical and Biological Research, 1997
The aim of the present study was to evaluate renal and liver distribution of two monoclonal immunoglobulin light chains. The chains were purified individually from the urine of patients with multiple myeloma and characterized as lambda light chains with ...
M.J.B.A. Prado, A.L. Nicastri, P.L.A. Costa, T. Rockman, I.L.S. Tersariol, H.B. Nader, R.T. Barros, E.B.A. Prado   +7 more
doaj  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source