Results 21 to 30 of about 218 (190)
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
Practical Laboratory Medicine, 2021 Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah +4 more
doaj
Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data [PDF]
PLoS Comput Biol 15(7): e1007133 (2019), 2017 The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several hundred known V alleles.
arxiv +1 more source
Animal Biotechnology, 1990 Abstract Restriction fragment length polymorphisms (RFLP) were found when BamHI, PvuII and HindIII digested horse genomic DNA was probed with an insert containing the gene sequences for human immunoglobul in gamma‐4 constant region. Family studies demonstrated that BamHI RFLPs of 5.1 and 4.8 KB represented allelic genes.
Ann Marie K. Rossi, Ernest Bailey
openaire +2 more sources
Goodness‐of‐fit tests in proportional hazards models with random effects
Biometrical Journal, Volume 65, Issue 1, January 2023., 2023 Abstract This paper deals with testing the functional form of the covariate effects in a Cox proportional hazards model with random effects. We assume that the responses are clustered and incomplete due to right censoring. The estimation of the model under the null (parametric covariate effect) and the alternative (nonparametric effect) is performed ...
Wenceslao González‐Manteiga +2 more
wiley +1 more source
SYNTHESIS AND ASSEMBLY OF IMMUNOGLOBULINS BY MALIGNANT HUMAN PLASMACYTES [PDF]
The Journal of Experimental Medicine, 1970 Three basic patterns of γ-globulin synthesis are described in malignant human plasmacytes: extreme unbalanced synthesis where only L chains are synthesized; unbalanced synthesis in which intact γG globulin and an excess of free L chains are synthesized and secreted; and balanced synthesis where H and L chains appear to be synthesized in equimolar ...
Joel Buxbaum +3 more
openaire +3 more sources
Frontiers in Genetics, 2019 The adaptive immune receptors repertoire is highly plastic, with its ability to produce antigen-binding molecules and select those with high affinity for their antigen.
Salvatrice Ciccarese +10 more
doaj +1 more source
A Case Report of Atypical Presentation of Multiple Myeloma on Serum Protein Electrophoresis [PDF]
Journal of Krishna Institute of Medical Sciences University, 2018 Multiple myeloma is a group of B-cell disorders resulting in the secretion of a specific and unique monoclonal immunoglobulin (M-protein). Protein electrophoresis is advised whenever multiple myeloma is suspected.
Pooja P. Padasal, Anil Malleshappa
doaj
Expression and Modulation of the Human Immunoglobulin A Fc Receptor (CD89) and the FcR γ Chain on Myeloid Cells in Blood and Tissue [PDF]
Scandinavian Journal of Immunology, 2003 AbstractCD89, the human immunoglobulin A (IgA) Fc receptor (FcR), is a potential target for antibody‐based therapeutics, but little is known about its expression and modulation in vivo. In this study, we examined the expression pattern of CD89 and its signalling subunit, the FcR γ chain, on circulating myeloid cells and in various tissues.
H. C. Morton +3 more
openaire +3 more sources
LifeThe purpose of this study was to develop a monoclonal antibody (mAb) that can identify porcine dendritic cells (DCs) that have differentiated from bone marrow progenitor cells.
Sang Eun Kim +3 more
doaj +1 more source