Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age [PDF]
Frontiers in Immunology, 2020 B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied.
Marie Ghraichy +18 more
doaj +8 more sources
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire. [PDF]
Nat Commun, 2023 Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated.
Rodriguez OL +12 more
europepmc +2 more sources
A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus. [PDF]
Front Immunol, 2020 An incomplete ascertainment of genetic variation within the highly polymorphic immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors that influence antibody and B cell mediated processes.
Rodriguez OL +14 more
europepmc +2 more sources
Immunoglobulin heavy chain gene rearrangement in heavy chain deposition disease suggests it is a plasma cell disease: a case report [PDF]
Journal of International Medical Research, 2022 Heavy chain deposition disease (HCDD) is characterized by the deposition of truncated monoclonal immunoglobulin heavy chains along glomerular basement membranes.
Qingqing Rao, Ricong Xu, Qijun Wan
doaj +2 more sources
A novel liver-specific immunoglobulin heavy chain-like gene in a cartilaginous fish [PDF]
Fish and Shellfish Immunology Reports, 2023 We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark Triakis scyllium by preliminary transcriptomic analysis.
Hidehiro Kondo +7 more
doaj +2 more sources
Computational Inference, Validation, and Analysis of 5’UTR-Leader Sequences of Alleles of Immunoglobulin Heavy Chain Variable Genes [PDF]
Frontiers in Immunology, 2021 Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. Inference from large, rearranged immunoglobulin
Yixun Huang +2 more
doaj +2 more sources
Monoclonal immunoglobulin heavy chain gene rearrangement in Fuchs’ uveitis [PDF]
BMC Ophthalmology, 2018 Background Fuchs’ uveitis (FU) is occasionarlly complicated with heavy vitreous opacity. We have performed vitrectomy procedures to remove vitreous opacity in affected patients as part of differential diagnosis for primary vitreoretinal lymphoma (PVRL ...
Hisae Nakahara +10 more
doaj +2 more sources
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1982 A chromosomal segment with a unique structure around the immunoglobulin heavy chain joining region (JH) has been molecularly cloned from an Abelson murine leukemia virus-transformed cell line.
F. Alt, D. Baltimore
semanticscholar +3 more sources
SWIGH-SCORE: A translational light-weight approach in computational detection of rearranged immunoglobulin heavy chain to be used in monoclonal lymphoproliferative disorders [PDF]
MethodsXWe present a lightweight tool for clonotyping and measurable residual disease (MRD) assessment in monoclonal lymphoproliferative disorders. It is a translational method that enables computational detection of rearranged immunoglobulin heavy chain gene ...
Marcus Høy Hansen +3 more
doaj +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1974 J. Donald Capra, J. Michael Kehoe
openalex +2 more sources