Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells [PDF]
Haematologica, 2013 Cytogenetic studies in clonal plasma cell disorders have mainly been done in whole bone marrow or CD138+ microbead-enriched plasma cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g.
Martin Schmidt-Hieber +12 more
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Expression cloning and production of Human Heavy Chain Only antibodies from murine transgenic plasma cells [PDF]
Frontiers in Immunology, 2016 Several technologies have been developed to isolate human antibodies against different target antigens as a source of potential therapeutics, including hybridoma technology, phage and yeast display systems.
Dubravka Drabek +7 more
doaj +5 more sources
Disseminated Intravascular Coagulation Associated with Large Deletion of Immunoglobulin Heavy Chain
Iranian Journal of Allergy, Asthma and Immunology, 2021 Although the majority of monogenic defects underlying primary immunodeficiency are microlesions, large lesions like large deletions are rare and constitute less than 10% of these patients.
Abbas Khalili +4 more
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Diagnostic Pathology, 2022 Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda +9 more
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Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case
Saudi Journal of Kidney Diseases and Transplantation, 2021 The occurrence of kidney diseases associated with a monoclonal gammopathy in the absence of symptomatic multiple myeloma is increasingly recognized. When the kidney is involved, the monoclonal etiology of these diseases results in clinical and laboratory
Rohit Tewari +5 more
doaj +1 more source
Immunoglobulin heavy chain exclusion in the shark. [PDF]
PLoS Biology, 2008 The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes.
Karolina Malecek +6 more
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Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch. [PDF]
PLoS ONE, 2017 Previous studies on a limited number of birds suggested that the IgD-encoding gene was absent in birds. However, one of our recent studies showed that the gene was definitely expressed in the ostrich and emu.
Binyue Han +5 more
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Mediterranean Journal of Hematology and Infectious Diseases, 2023 Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains.
Maria Laura Bisegna +5 more
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Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies [PDF]
, 2021 Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions of genomic material known as indels.
arxiv +1 more source
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
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