Results 131 to 140 of about 225,064 (376)

Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosis.

American Society of Nephrology. Clinical Journal, 2010
BACKGROUND AND OBJECTIVES Amyloidosis is a group of disorders characterized by accumulation of extracellular deposition of proteins as insoluble aggregates.
S. Sethi, J. Theis, N. Leung, A. Dispenzieri, S. Nasr, M. Fidler, L. Cornell, Jeffrey D. Gamez, J. Vrana, A. Dogan   +9 more
semanticscholar   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source

Clinical significance of LAIR1 (CD305) as assessed by flow cytometry in a prospective series of patients with chronic lymphocytic leukemia

Haematologica, 2014
Most patients affected by chronic lymphocytic leukemia are diagnosed by flow cytometry. Several immunophenotypic markers have been identified as significant and independent prognostic variables, especially from retrospective cohorts.
Omar Perbellini, Erika Falisi, Ilaria Giaretta, Elisa Boscaro, Elisabetta Novella, Monica Facco, Stefania Fortuna, Silvia Finotto, Eliana Amati, Francesco Maniscalco, Anna Montaldi, Alberta Alghisi, Fiorenza Aprili, Laura Bonaldi, Rossella Paolini, Maria Teresa Scupoli, Livio Trentin, Achille Ambrosetti, Gianpietro Semenzato, Giovanni Pizzolo, Francesco Rodeghiero, Carlo Visco   +21 more
doaj   +1 more source

Human immunoglobulin heavy-chain multigene deletions in healthy individuals [PDF]

, 1987
Extensive multigene deletions have been described in the human immunoglobulin heavy-chain constant region genes, some of them encompassing perhaps more than 100 kilobases.
Lefranc, Gérard, Lefranc, Marie-Paule
core   +1 more source

AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering

Advanced Science, EarlyView.
AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun, Jiayi Yuan, Divya Jaiswal, Jingxuan Ge, Tianjian Liang, Jiahui Wei, Jinghong Cao, Yulong Li, Xiaojie Chu, Yan Chen, Ying Xue, Wei Li, Tingjun Hou, Zhiwei Feng   +13 more
wiley   +1 more source

The structures of secretory and dimeric immunoglobulin A [PDF]

, 2020
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA ...
Haloi, Nandan, Huey-Tubman, Kathryn E., Kumar Bharathkar, Sonya, Malyutin, Andrey G., Parker, Benjamin W., Stadtmueller, Beth M., Tajkhorshid, Emad   +6 more
core  

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Denecke, J. (Jurgen), Frigerio, Lorenzo, Hadlington, Jane L., Ma, Julian K.-C., Nuttall, James, Santoro, Aniello, Vitale, A. (Alessandro)   +6 more
core   +2 more sources

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Our Experiences With B Cell Clonality Analysis Using Multiplex Pcr Amplification in Paraffin-Embedded Tissue

Acta Medica Martiniana, 2014
The clonal determination of B-cell lymphoproliferative diseases by immunoglobulin heavy chain (IgH) rearrangement by polymerase chain reaction (PCR) is widely used.
Stanek L., Llsova S., Tvrdlk D.
doaj   +1 more source

DNA PCR Assays for Igh Rearrangement

Bio-Protocol, 2014
This protocol is used for the detection of immunoglobulin heavy (H) chain rearrangements. This PCR-based assay enables detection of DH-JH recombination in cultured hematopoietic cells (Schlissel et al., 1991; Satoh et al., 2013) [e.g.
Yusuke Satoh, Takao Sudo, Takafumi Yokota   +2 more
doaj   +1 more source