Results 21 to 30 of about 116,527 (269)
Haematologica, 2013 Cytogenetic studies in clonal plasma cell disorders have mainly been done in whole bone marrow or CD138+ microbead-enriched plasma cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g.
Martin Schmidt-Hieber +12 more
doaj +1 more source
Characterization of immunoglobulin heavy chain knockout rats [PDF]
European Journal of Immunology, 2010 AbstractThe rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene‐specific mutations. In a recent study, we described for the first time the generation of novel rat lines with targeted mutations using zinc‐finger nucleases.
Gregory J. Cost +9 more
openaire +3 more sources
Frontiers in Immunology, 2021 Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. Inference from large, rearranged immunoglobulin
Yixun Huang +2 more
doaj +1 more source
Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
Nature Communications, 2019 Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin ...
Benjamin G. Barwick +13 more
doaj +1 more source
Human Immunoglobulin Heavy Chain Genes
Journal of Biological Chemistry, 1989 genes in man, has lagged surprisingly behind similar information in the inbred mouse. The reasons for this are complicated but to some extent are related to the discovery of the myc oncogene. Thus, after genes encoding some of the constant region isotypes as well as the well defined “subgroups,”
Philip W. Tucker, J D Capra
openaire +3 more sources
HEAVY-CHAIN DISEASES AND MYELOMA-ASSOCIATED FANCONI SYNDROME: AN UPDATE
Mediterranean Journal of Hematology and Infectious Diseases, 2018 The heavy chain diseases (HCDs) are rare B-cell malignancies characterized by the production of a monoclonal immunoglobulin heavy chain without an associated light chain.
Roberto Ria +2 more
doaj +1 more source
mAbs, 2021 Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work
Pin-Kuang Lai +5 more
doaj +1 more source
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020 Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Frontiers in Cell and Developmental Biology, 2020 Somatic hypermutation (SHM) status provides an important prognostic indicator for chronic lymphocytic leukemia (CLL), a very common type of mature B-cell leukemia.
Sanjeev Kumar Gupta +2 more
doaj +1 more source