Results 21 to 30 of about 167,466 (331)
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
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Immunoglobulin Heavy Chain Diversity Region
Definitions, 2020 The portion of the immunoglobulin heavy chain hypervariable region of immunoglobulin molecules that is found between the variable (V) and joining (J) elements.
semanticscholar +1 more source
Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus. [PDF]
PLoS ONE, 2014 Cattle have a limited range of immunoglobulin genes which are further diversified by antigen independent somatic hypermutation in fetuses. Junctional diversity generated during somatic recombination contributes to antibody diversity but its relative ...
Jenni Liljavirta +4 more
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BMC Nephrology, 2018 Background Immunoglobulin heavy-and-light-chain amyloidosis (AHL amyloidosis) is a newly established disease entity where both the immunoglobulin heavy-chain and light-chain compose amyloid fibrils. The immunoglobulins responsible for the amyloid fibrils
Shun Manabe +6 more
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BMC Nephrology, 2023 Background Light and heavy chain deposition disease (LHCDD) is a rare condition characterised by the deposition of immunoglobulin components in the kidneys.
Yuki Shimamoto +11 more
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BioTechniques, 2021 IgA nephropathy (IgAN) is an autoimmune disease characterized by renal glomerular immunodeposits enriched for galactose-deficient IgA1 (Gd-IgA1; autoantigen) with the corresponding IgG autoantibodies.
Colin Reily, Nuo Xu, David K Crossman
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Distribution of immunoglobulin heavy chains in diseased synovia. [PDF]
Journal of Clinical Pathology, 1986 Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains. A high proportion of plasma cells in the superficial subintima in all diseases reacted for alpha heavy chains. Only in rheumatoid disease did the synovium contain more than 10% of plasma cells reacting
Freemont, AJ, Rutley, C.
openaire +4 more sources
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
European Journal of Biochemistry, 2005 A procedure is described for the large-scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice. Intact RNA is selectively precipitated in high yield from frozen tumors homogenized in 3 M LiCl and 6 M urea.
C. Auffray, F. Rougeon
semanticscholar +1 more source
Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]
PLoS ONE, 2018 Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs +11 more
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Haematologica, 2013 Cytogenetic studies in clonal plasma cell disorders have mainly been done in whole bone marrow or CD138+ microbead-enriched plasma cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g.
Martin Schmidt-Hieber +12 more
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