Results 341 to 350 of about 225,064 (376)

The origin of light and heavy chains of immunoglobulins

Biochemical and Biophysical Research Communications, 1971
Abstract A model is proposed for the origin of H chains of Ig by the translocation of vc1 gene for light chains to a c2c3 gene giving rise to a vc1c2c3 gene. This explains why the common part of H chain is three times longer than the variable part.
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J Genes for Heavy Chain Immunoglobulins of Mouse

Science, 1980
A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4Aλ phage vector system, was shown to contain the μ heavy chain constant region (C H μ) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of
Newell, N, Richards, J E, Tucker, P W, Blattner, F R   +3 more
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Whale immunoglobulins—II. Heavy chain structure

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1972
Abstract 1. 1. Immunoglobulins (7S) were purified from the plasmas of three species of whales, hump-backed, fin-backed and Sei. 2. 2. Heavy polypeptide chains were characterized and compared to human γ chains. 3. 3. Amino acid composition and peptide map comparisons indicated much homology between the whale 7S Ig heavy chain and hyman γ.
Bob G. Sanders, James C. Travis
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Rat immunoglobulin E heavy chain locus

Journal of Molecular Biology, 1984
A 2100 base-pair long sequence has been established which covers all four constant domains of the rat epsilon-chain. An analysis of messenger RNA from an immunoglobulin E producing rat immunocytoma revealed two separate epsilon-chain mRNA species, 2.3 X 10(3) and 2.8 X 10(3) base-pairs long.
Marie-Louise Steen, Ulf Pettersson, Lars Hellman   +2 more
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Organization of the Human Immunoglobulin Heavy-Chain Locus

1996
Immunoglobulin (Ig) heavy-chain (H) genes cluster at three loci in the human genome; the distal region of chromosome 14(1), chromosome 15(2) and chromosome 16(3). Among these only the chromosome 14 locus has been shown to generate a functional Ig gene by recombination of the variable (VH), diversity (D) and joining (JH) segments.
Fumihiko Matsuda, Tasuku Honjo
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Evolution of the Antarctic teleost immunoglobulin heavy chain gene

Molecular Phylogenetics and Evolution, 2010
Notothenioid teleosts underwent major modifications of their genome to adapt to the cooling of the Antarctic environment. In order to identify specific features of the Antarctic teleost immunoglobulin, transcripts encoding the constant region of the IgM heavy chain from 13 Antarctic and non-Antarctic notothenioid species were sequenced.
Coscia MR, Varriale S, De Santi C, Giacomelli S, Oreste U   +4 more
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Heavy Chain Fibrillary Glomerulonephritis: A Case Report.

American Journal of Kidney Diseases, 2019
Heavy chain amyloidosis and heavy chain deposition disease are the only known kidney diseases caused by the deposition of truncated immunoglobulin heavy chains.
S. Nasr, C. Sirac, F. Bridoux, V. Javaugue, S. Bender, A. Rinsant, S. Kaaki, É. Pinault, S. Dasari, M. Alexander, Samar Said, Jonathan J. Hogan, A. Dispenzieri, G. Touchard, E. McPhail, N. Leung   +15 more
semanticscholar   +1 more source

Primary and secondary variants in immunoglobulin heavy chain production

Nature, 1976
WE have isolated numerous variants of a mouse myeloma cell line which synthesised altered heavy immunoglobulin chains and normal light chains after treating the line with the acridine mustard ICR-191 (refs 1–4). The four types of primary variants that we found are shown in Table 1.
Saija Koskimies, Saija Koskimies, Barbara K. Birshtein   +2 more
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Reassembly of Immunoglobulin M Heavy and Light Chains In Vitro

Scandinavian Journal of Immunology, 1976
Reduced and alleviated monoclonal IgM was fractionated into μ and light (L) chains by gel chromatography in 1N acetic acid. Equimolar mixtures of the chains formed a noncovalently bonded structure in 0.01M sodium acetate buffer, pH 4.1, that had the properties of a half subunit.
R. B. Hester, R. E. Schrohenloher
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The role of gene deletion in the immunoglobulin heavy chain switch

Nature, 1980
We have examined the arrangement of the genes for the mouse heavy chain subclasses gamma 2b, gamma 2a and gamma 1 by the Southern hybridisation procedure. Evidence has been found for rearrangement involving the gamma 2b and gamma 2a CH genes in the DNA of cells making IgG2b and IgG2a respectively.
Terence H. Rabbitts, David Bentley, W. Dunnick, Alan Forster   +3 more
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