Results 31 to 40 of about 235,597 (396)

IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications [PDF]

, 2019
The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples ...
Amato, Teresa, Aversa, Sara, Bellan, Cristiana, Cencini, Emanuele, Cevenini, Gabriele, DI NAPOLI, Arianna, Di Stefano, Gioia, Giulio Carta, Alberto, Granai, Massimo, Kovalchuk, Sofya, Lazzi, Stefano, Leoncini, Lorenzo, Mancini, Virginia, Santi, Raffaella, Vergoni, Federica, Ziepert, Marita   +15 more
core   +2 more sources

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source

Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells

Haematologica, 2013
Cytogenetic studies in clonal plasma cell disorders have mainly been done in whole bone marrow or CD138+ microbead-enriched plasma cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g.
Martin Schmidt-Hieber, María Laura Gutiérrez, Martin Pérez-Andrés, Bruno Paiva, Ana Rasillo, Maria Dolores Tabernero, José Maria Sayagués, Antonio Lopez, Paloma Bárcena, María Luz Sanchez, Norma C. Gutiérrez, Jesus F. San Miguel, Alberto Orfao   +12 more
doaj   +1 more source

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Nature Communications, 2017
The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying
T. Parks, M. Mirabel, J. Kado, K. Auckland, Jaroslaw Nowak, A. Rautanen, A. Mentzer, É. Marijon, X. Jouven, Mai Ling Perman, Tuliana Cua, J. Kauwe, John B. Allen, Henry Taylor, K. Robson, C. Deane, A. Steer, A. Hill, Lori Marvin Corinne Samantha M. Aurélia Maureen Rina Wi Allen Allen Braunstein Colquhoun Jewine Ah Kee Kum, Lori B. Allen, M. Allen, C. Braunstein, Samantha M. Colquhoun, Aurélia Jewine, Maureen Ah Kee, R. Kumar, W. John Martin, Reapi L. Mataika, M. Nadra, Shahin Nadu, T. Naseri, B. Noël, Nathalie Simon, Brenton Ward   +33 more
semanticscholar   +1 more source

Human Immunoglobulin Heavy Chain Genes

Journal of Biological Chemistry, 1989
genes in man, has lagged surprisingly behind similar information in the inbred mouse. The reasons for this are complicated but to some extent are related to the discovery of the myc oncogene. Thus, after genes encoding some of the constant region isotypes as well as the well defined “subgroups,”
Philip W. Tucker, J D Capra
openaire   +3 more sources

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Nature Communications, 2019
Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin ...
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise   +13 more
doaj   +1 more source

Rearrangement of Immunoglobulin Genes in Tumor Cells of Patients with Primary Mediastinal (Thymic) Large B-Cell Lymphoma

Клиническая онкогематология, 2019
Background. Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a malignant tumor with large atypical lymphoid cells expressing post-germinal differentiation markers.
YaK Mangasarova, YuV Sidorova, AU Magomedova, BV Biderman, EE Nikulina, AB Sudarikov, AM Kovrigina, SK Kravchenko   +7 more
doaj   +1 more source

Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]

, 2004
86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Allen RC, Aruffo A, Bonhomme D, Fuleihan R, Lin Q, Mayer L, Ramesh N, Seyama K, Webster ADB, WHO Scientific Group.   +9 more
core   +3 more sources

Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity

Haematologica, 2016
Immunoglobulin heavy chain ( IGH ) and light chain gene sequences of 27 patients with primary cold agglutinin disease (CAD) were studied to find features explaining the heterogeneity of clinical presentation and disease activity.
A. Małecka, G. Trøen, A. Tierens, I. Østlie, J. Malecki, Ulla Randen, S. Berentsen, G. Tjønnfjord, J. Delabie   +8 more
semanticscholar   +1 more source

Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma [PDF]

, 2010
We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript.
Jakovljević, Gordana, Kardum-Skelin, Ika, Krušlin, Božo, Mrsić-Davidović, Sanja, Nakić, Melita, Rogošić, Srđan, Zadro, Renata   +6 more
core   +1 more source