Results 31 to 40 of about 167,466 (331)

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Nature Communications, 2017
The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying
T. Parks, M. Mirabel, J. Kado, K. Auckland, Jaroslaw Nowak, A. Rautanen, A. Mentzer, É. Marijon, X. Jouven, Mai Ling Perman, Tuliana Cua, J. Kauwe, John B. Allen, Henry Taylor, K. Robson, C. Deane, A. Steer, A. Hill, Lori Marvin Corinne Samantha M. Aurélia Maureen Rina Wi Allen Allen Braunstein Colquhoun Jewine Ah Kee Kum, Lori B. Allen, M. Allen, C. Braunstein, Samantha M. Colquhoun, Aurélia Jewine, Maureen Ah Kee, R. Kumar, W. John Martin, Reapi L. Mataika, M. Nadra, Shahin Nadu, T. Naseri, B. Noël, Nathalie Simon, Brenton Ward   +33 more
semanticscholar   +1 more source

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Nature Communications, 2019
Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin ...
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise   +13 more
doaj   +1 more source

Human Immunoglobulin Heavy Chain Genes

Journal of Biological Chemistry, 1989
genes in man, has lagged surprisingly behind similar information in the inbred mouse. The reasons for this are complicated but to some extent are related to the discovery of the myc oncogene. Thus, after genes encoding some of the constant region isotypes as well as the well defined “subgroups,”
Philip W. Tucker, J D Capra
openaire   +3 more sources

Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity

Haematologica, 2016
Immunoglobulin heavy chain ( IGH ) and light chain gene sequences of 27 patients with primary cold agglutinin disease (CAD) were studied to find features explaining the heterogeneity of clinical presentation and disease activity.
A. Małecka, G. Trøen, A. Tierens, I. Østlie, J. Malecki, Ulla Randen, S. Berentsen, G. Tjønnfjord, J. Delabie   +8 more
semanticscholar   +1 more source

Rearrangement of Immunoglobulin Genes in Tumor Cells of Patients with Primary Mediastinal (Thymic) Large B-Cell Lymphoma

Клиническая онкогематология, 2019
Background. Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a malignant tumor with large atypical lymphoid cells expressing post-germinal differentiation markers.
YaK Mangasarova, YuV Sidorova, AU Magomedova, BV Biderman, EE Nikulina, AB Sudarikov, AM Kovrigina, SK Kravchenko   +7 more
doaj   +1 more source

HEAVY-CHAIN DISEASES AND MYELOMA-ASSOCIATED FANCONI SYNDROME: AN UPDATE

Mediterranean Journal of Hematology and Infectious Diseases, 2018
The heavy chain diseases (HCDs) are rare B-cell malignancies characterized by the production of a monoclonal immunoglobulin heavy chain without an associated light chain.
Roberto Ria, Franco Dammacco, Angelo Vacca   +2 more
doaj   +1 more source

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

mAbs, 2021
Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work
Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout   +5 more
doaj   +1 more source

Monitoring IgA multiple myeloma: immunoglobulin heavy/light chain assays.

Clinical Chemistry, 2015
BACKGROUND The use of electrophoresis to monitor monoclonal immunoglobulins migrating in the β fraction may be difficult because of their comigration with transferrin and complement proteins.
J. Katzmann, M. Willrich, Mindy C. Kohlhagen, R. Kyle, D. Murray, M. Snyder, S. Rajkumar, A. Dispenzieri   +7 more
semanticscholar   +1 more source

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Haematologica, 2014
In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can
K. Plevová, H. Francová, K. Burčková, Y. Brychtova, M. Doubek, S. Pavlova, J. Malcikova, J. Mayer, B. Tichy, Š. Pospíšilová   +9 more
semanticscholar   +1 more source

Evaluation of Somatic Hypermutation Status in Chronic Lymphocytic Leukemia (CLL) in the Era of Next Generation Sequencing

Frontiers in Cell and Developmental Biology, 2020
Somatic hypermutation (SHM) status provides an important prognostic indicator for chronic lymphocytic leukemia (CLL), a very common type of mature B-cell leukemia.
Sanjeev Kumar Gupta, David S. Viswanatha, Keyur P. Patel   +2 more
doaj   +1 more source