Results 71 to 80 of about 221,625 (273)

Genetic pathogenesis of immunoglobulin light chain amyloidosis: basic characteristics and clinical applications

Experimental Hematology & Oncology, 2021
Immunoglobulin light chain amyloidosis (AL) is an indolent plasma cell disorder characterized by free immunoglobulin light chain (FLC) misfolding and amyloid fibril deposition.
Linchun Xu, Yongzhong Su
doaj   +1 more source

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia.

New England Journal of Medicine, 2004
BACKGROUND The course of chronic lymphocytic leukemia (CLL) is variable. In aggressive disease, the CLL cells usually express an unmutated immunoglobulin heavy-chain variable-region gene (IgV(H)) and the 70-kD zeta-associated protein (ZAP-70), whereas in
L. Rassenti, L. Huynh, Tracey Toy, Liguang Chen, M. Keating, J. Gribben, D. Neuberg, I. Flinn, K. Rai, J. Byrd, N. Kay, Andrew W. Greaves, A. Weiss, T. Kipps   +13 more
semanticscholar   +1 more source

Monoclonal gammopathy with systemic amylodosis: an evaluation of diagnostic elements [PDF]

, 2011
Monoclonal gammopathies result from an overproduction of a single abnormal clone of plasma cell or B lymphocyte that produce an immunologically homogenous immunoglobulin (Ig) commonly referred to as paraprotein or monoclonal (M) protein.
Chellappah Thambiah, Subashini, George, Elizabeth, Umar, Nor Aini   +2 more
core  

The Immunoglobulins of Cold-Blooded Vertebrates [PDF]

, 2014
Peer reviewedPublisher ...
Chen, Clem, Cone, Cooper, Crouch, Deza, Grey, Hadji-Azimi, Hsu, Kokubu, Leslie, Magor, Malecek, Mansikka, Patel, Schaerlinger, Schaerlinger, Small, Steiner, Turchin, Wilson, Wu, Zapata   +22 more
core   +2 more sources

Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.

Blood, 2005
We analyzed the immunoglobulin (Ig) variable heavy (IGHV) and variable light chain genes used by leukemia cells of 258 unrelated patients with chronic lymphocytic leukemia (CLL) found to express unmutated Ig heavy chains (IgH) encoded by a 51p1 allele of
G. Widhopf, Craig J. Goldberg, Traci L. Toy, L. Rassenti, W. Wierda, J. Byrd, M. Keating, J. Gribben, K. Rai, T. Kipps   +9 more
semanticscholar   +1 more source

Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice [PDF]

, 2006
SummarySystemic lupus erythematosus (SLE) is characterized by the production of autoantibodies that are frequently directed against nucleic acid-associated antigens. To better understand how B cells reactive with such antigens are regulated, we generated
Akira, Shizuo, Berland, Robert, Fernandez, Luis, Han, Jin-Hwan, Imanishi-Kari, Thereza, Kari, Elina, Kearney, John F., Lomakin, Ina, Ucci, Angelo A., Wortis, Henry H.   +9 more
core   +1 more source

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

Haematologica, 2019
Chronic lymphocytic leukemia cells have an altered energy metabolism compared to normal B cells. While there is a growing understanding of the molecular heterogeneity of the disease, the extent of metabolic heterogeneity and its relation to molecular ...
Junyan Lu, Martin Böttcher, Tatjana Walther, Dimitrios Mougiakakos, Thorsten Zenz, Wolfgang Huber   +5 more
doaj   +1 more source

Sequencing B cell receptors from ferrets (Mustela putorius furo).

PLoS ONE, 2020
The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunological insights are restricted due to a lack of ferret-specific reagents and limited genetic information about ferret B and T
Julius Wong, Celeste M Tai, Aeron C Hurt, Hyon-Xhi Tan, Stephen J Kent, Adam K Wheatley   +5 more
doaj   +1 more source

Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia.

Blood, 2012
The ability to distinguish clonal B-cell populations based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important tool for diagnosing B-cell neoplasms and monitoring treatment response.
Charles Gawad, F. Pépin, V. Carlton, M. Klinger, A. Logan, D. Miklos, M. Faham, G. Dahl, Norman J. Lacayo   +8 more
semanticscholar   +1 more source

Evolution of antigen binding receptors [PDF]

, 1999
This review addresses issues related to the evolution of the complex multigene families of antigen binding receptors that function in adaptive immunity.
Anderson, Michele K., Litman­, Gary W., Rast­, ­Jonathan P.   +2 more
core   +1 more source