Results 1 to 10 of about 165,170 (370)
Immunoglobulin heavy chains in medaka (Oryzias latipes) [PDF]
BMC Evolutionary Biology, 2011 Abstract Background Bony fish present an immunological system, which evolved independently from those of animals that migrated to land 400 million years ago. The publication of whole genome sequences and the availability of several cDNA libraries for medaka (Oryzias latipes) permitted us to perform a thorough analysis
Magadán-Mompó, S. (Susana) +2 more
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The Translation in vitro of mRNA for Immunoglobulin Heavy Chains [PDF]
European Journal of Biochemistry, 1973 The addition of mRNA preparations to a number of heterologous cell‐free systems has been shown to result in the synthesis of immunoglobulin light chains. This paper reports the results of experiments in which an mRNA fraction prepared from MOPC 21 mouse myeloma cells has been used to stimulate the synthesis of immunoglobulin heavy chains in rabbit ...
N.J. Cowan, Cesar Milstein
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Polymorphism in immunoglobulin heavy chains suggesting gene conversion. [PDF]
Proceedings of the National Academy of Sciences, 1982 Complete heavy (H) chain variable region (V region; amino acids 1-118) sequences have been determined for three phosphocholine (PCho)-binding monoclonal antibodies of CBA mouse strain origin. Two of these were found to differ from the sequence of the BALB/c T15 germline VH segment (segment of the V region that includes amino acids 1-95) at four ...
Clarke, S H, Claflin, J L, Rudikoff, S
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Immunoglobulin heavy-chain-associated amyloidosis. [PDF]
Proceedings of the National Academy of Sciences, 1990 Immunoglobulin- or multiple myeloma-associated amyloidosis has been distinguished by the tissue deposition of Congophilic, fibrillar protein consisting of light chains or light-chain fragments (AL amyloidosis). We now report the isolation and characterization of another form of immunoglobulin-associated amyloid obtained from a patient who had extensive
Alan Solomon +2 more
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Distribution of immunoglobulin heavy chains in diseased synovia. [PDF]
Journal of Clinical Pathology, 1986 Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains. A high proportion of plasma cells in the superficial subintima in all diseases reacted for alpha heavy chains. Only in rheumatoid disease did the synovium contain more than 10% of plasma cells reacting
Freemont, AJ, Rutley, C.
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Immunoglobulin Heavy Chain Exclusion in the Shark
PLoS Biology, 2008 The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain ...
Wendy Feng +6 more
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Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age [PDF]
Frontiers in Immunology, 2020 B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires.
Marie Ghraichy +18 more
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Characterization of immunoglobulin heavy chain knockout rats [PDF]
European Journal of Immunology, 2010 AbstractThe rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene‐specific mutations. In a recent study, we described for the first time the generation of novel rat lines with targeted mutations using zinc‐finger nucleases.
Gregory J. Cost +9 more
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Human Immunoglobulin Heavy Chain Genes
Journal of Biological Chemistry, 1989 genes in man, has lagged surprisingly behind similar information in the inbred mouse. The reasons for this are complicated but to some extent are related to the discovery of the myc oncogene. Thus, after genes encoding some of the constant region isotypes as well as the well defined “subgroups,”
Philip W. Tucker, J D Capra
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Immunoglobulin heavy chain patterns in reactive lymphadenopathy. [PDF]
Journal of Clinical Pathology, 1991 Thirty one lymph nodes taken from 24 benign reactive cases, three cases of angiolymphoid hyperplasia with eosinophilia, one case of Kimura's disease and three cases of Hodgkin's disease, were stained for immunoglobulin heavy chains IgG, IgM, IgA and IgE using the peroxidase-antiperoxidase method.
T Rhodes, M Sundaresan, A B Akosa
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