Immunoglobulin heavy chains in medaka (
BMC Evolutionary Biology, 2011 Background Bony fish present an immunological system, which evolved independently from those of animals that migrated to land 400 million years ago.
Gambón-Deza Francisco +2 more
doaj +10 more sources
Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1975 Cells of the MPC-11 mouse myeloma cell line, which produces an IgG2b immunoglobulin, were subjected to mutagenesis with Melphalan or with ICR-191, after which they were cloned in soft agar.
J. Preud’homme +2 more
semanticscholar +2 more sources
Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein [PDF]
Journal of Cell Biology, 1987 Heavy chain-binding protein (BiP) associates posttranslationally with nascent Ig heavy chains in the endoplasmic reticulum (ER) and remains associated with these heavy chains until they assemble with light chains.
L. Hendershot +3 more
semanticscholar +2 more sources
Subgroups of amino acid sequences in the variable regions of immunoglobulin heavy chains.
Proceedings of the National Academy of Sciences of the United States of America, 1969 The amino acid sequence of the first 133 residues of the heavy (gamma) chain from a human gammaG immunoglobulin (He) has been determined. This gamma-chain is identical in Gm type to that of protein Eu, the complete sequence of which has been reported ...
B. A. Cunningham +3 more
semanticscholar +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1974 The variable regions of five human immunoglobulin heavy chains of the V(H)III subgroup have been totally sequenced. Three of the heavy chains belonged to the IgG class and two to the IgA class.
J. Capra, J. Kehoe
semanticscholar +2 more sources
Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1979 To investigate the organization of immunoglobulin genes, we have constructed a clone library containing 10(6) randomly generated fragments of mouse embryo DNA, corresponding to eight equivalents of the genome.
D. Kemp, S. Cory, J. M. Adams
semanticscholar +2 more sources
Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.
Proceedings of the National Academy of Sciences of the United States of America, 1976 The entire sequences of the heavy chain variable regions of M167 and TEPC 15 (phosphorylcholine-binding myeloma proteins of BALB/c origin) have been determined. These sequences are compared with the phosphorylcholine-binding protein M603.
S. Rudikoff, M. Potter
semanticscholar +2 more sources
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +2 more sources
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
doaj +1 more source
Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?
Antibodies, 2022 When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells.
Siqi Gong +4 more
doaj +1 more source