Results 41 to 50 of about 172,498 (401)

Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion

Cell Death and Disease, 2023
Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light chains. However,
Alice Capuz, Sylvain Osien, Mélodie Anne Karnoub, Soulaimane Aboulouard, Estelle Laurent, Etienne Coyaud, Antonella Raffo-Romero, Marie Duhamel, Amélie Bonnefond, Mehdi Derhourhi, Marco Trerotola, Ikram El Yazidi-Belkoura, David Devos, Monika Zilkova, Firas Kobeissy, Fabien Vanden Abeele, Isabelle Fournier, Dasa Cizkova, Franck Rodet, Michel Salzet   +19 more
doaj   +1 more source

Evaluating the heavy/light chain immunoglobulin biomarker for early relapse detection in multiple myeloma: A comparative study with conventional methods

Clinical Immunology Communications
Objectives: The objective of this study is to evaluate the use of the immunoglobulin heavy/light chain biomarker in the early detection of biochemical relapse in patients with multiple myeloma under treatment.
Carla Azevedo, Ana Catarina Fonseca, João Pedro Barreto, Ana Marta Pires, Carina Faria, Andreia Pinto, Maria Emília Sousa, Carlos Palmeira, Cristina Prudêncio, Bruno Fernandes, Gabriela Martins, Ricardo Ferraz   +11 more
doaj   +1 more source

Avian Resistance to Campylobacter jejuni Colonization Is Associated with an Intestinal Immunogene Expression Signature Identified by mRNA Sequencing [PDF]

, 2012
peer-reviewedThis research was funded by the The Irish Department of Agriculture and Food’s Food Institutional Research Measure (http://www.agriculture.gov.ie/ research/foodinstitutionalresearchmeasurefirm) – Grant No: 06_RDD_486.Campylobacter jejuni is
Allan, Brenda, Bradley, Daniel G, Connell, Sarah, Cormican, Paul, Kenny, Elaine, Lloyd, Andrew T, Meade, Kieran G, Morris, Derek W., O'Farrelly, Cliona   +8 more
core   +3 more sources

Immunoglobulin Heavy Chain Exclusion in the Shark

PLoS Biology, 2008
The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain ...
Karolina Malecek, Victor Lee, Wendy Feng, Jing Li Huang, Martin F Flajnik, Yuko Ohta, Ellen Hsu   +6 more
openaire   +4 more sources

Human immunoglobulin heavy‐chain multigene deletions in healthy individuals [PDF]

FEBS Letters, 1987
Extensive multigene deletions have been described in the human immunoglobulin heavy‐chain constant region genes, some of them encompassing perhaps more than 100 kilobases. These deletions have all been observed in healthy individuals although these individuals lacked several immunoglobulin class or subclasses, being either homozygous for one deletion ...
Lefranc, Marie-Paule, Lefranc, Gérard
openaire   +2 more sources

Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

Frontiers in Immunology, 2016
Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend, Julie MJ Laffy, Yu-Chang Bryan Wu, Joselli Silva O'Hare, Victoria Martin, David Kipling, Franca Fraternali, Deborah K Dunn-Walters   +7 more
doaj   +1 more source

Identification of two rate-limiting steps in the degradation of partially folded immunoglobulin light chains

Frontiers in Cell and Developmental Biology, 2022
Antibody monomers are produced from two immunoglobulin heavy chains and two light chains that are folded and assembled in the endoplasmic reticulum This process is assisted and monitored by components of the endoplasmic reticulum quality control ...
Melissa J. Mann, Ashley R. Flory, Christina Oikonomou, Christina Oikonomou, Candace A. Hayes, Chris Melendez-Suchi, Linda M. Hendershot, Linda M. Hendershot   +7 more
doaj   +1 more source

Expression of the Thyroid Hormone Receptor Gene, erbAα, in B Lymphocytes: Alternative mRNA Processing is Independent of Differentiation but Correlates with Antisense RNA Levels [PDF]

, 1997
The erbAα gene encodes two α-thyroid hormone receptor isoforms, TRα1 and TRα2, which arise from alternatively processed mRNAs, erbAα1 (α1) and erb α2 (α2).
Hastings, Michelle Laura, Martincic, Kathlee, Milcarek, Christine, Munroe, Stephen H., Peterson, Martha L.   +4 more
core   +1 more source

Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]

, 2016
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC, Chen, Xiangjun, Liu, Wanli, Robinson, Marcus J, Smith, Geoffrey A, Taunton, Jack, Yang, Zhiyong   +6 more
core   +1 more source

Recombination of genes coding for constant and variable regions of immunoglobulin heavy chains.

Journal of Immunology, 1972
In one member of a rabbit family evidence has been obtained for a cross-over for genes coding from group a and group d rabbit heavy chain allotypic markers.
T. Kindt, W. Mandy
semanticscholar   +1 more source