Results 41 to 50 of about 136,376 (331)

Immunoglobulin genes and diversity: what we have learned from domestic animals

Journal of Animal Science and Biotechnology, 2012
This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi, Liu Zhancai, Ren Liming, Wei Zhiguo, Wang Ping, Li Ning, Zhao Yaofeng   +6 more
doaj   +1 more source

Variants of mouse myeloma cells that produce short immunoglobulin heavy chains.

Proceedings of the National Academy of Sciences of the United States of America, 1974
After mutagenesis of cultured mouse myeloma cells with ICR 191 or Melphalan, variant clones were isolated that synthesized immunoglobulin heavy chains shorter than those produced by the parent.
B. Birshtein, J. Preud’homme, M. Scharff   +2 more
semanticscholar   +1 more source

Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion

Cell Death and Disease, 2023
Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light chains. However,
Alice Capuz, Sylvain Osien, Mélodie Anne Karnoub, Soulaimane Aboulouard, Estelle Laurent, Etienne Coyaud, Antonella Raffo-Romero, Marie Duhamel, Amélie Bonnefond, Mehdi Derhourhi, Marco Trerotola, Ikram El Yazidi-Belkoura, David Devos, Monika Zilkova, Firas Kobeissy, Fabien Vanden Abeele, Isabelle Fournier, Dasa Cizkova, Franck Rodet, Michel Salzet   +19 more
doaj   +1 more source

Immunoglobulin heavy chain patterns in reactive lymphadenopathy. [PDF]

Journal of Clinical Pathology, 1991
Thirty one lymph nodes taken from 24 benign reactive cases, three cases of angiolymphoid hyperplasia with eosinophilia, one case of Kimura's disease and three cases of Hodgkin's disease, were stained for immunoglobulin heavy chains IgG, IgM, IgA and IgE using the peroxidase-antiperoxidase method.
T Rhodes, M Sundaresan, A B Akosa
openaire   +3 more sources

Presence of two different immunoglobulin heavy chains in individual cells of established human hematopoietic cell lines.

Journal of Immunology, 1968
Presence of γ-, α- and µ-heavy chains of immunoglobulin was examined in cultured cells of established human hematopoietic cell lines. Combinations of a fluorescein-conjugated antibody of one specificity and a tetramethylrhodamine-conjugated antibody of
M. Takahashi, N. Tanigaki, Yasuo Yagi, George E. Moore, David Pressman   +4 more
semanticscholar   +1 more source

Identification of two rate-limiting steps in the degradation of partially folded immunoglobulin light chains

Frontiers in Cell and Developmental Biology, 2022
Antibody monomers are produced from two immunoglobulin heavy chains and two light chains that are folded and assembled in the endoplasmic reticulum This process is assisted and monitored by components of the endoplasmic reticulum quality control ...
Melissa J. Mann, Ashley R. Flory, Christina Oikonomou, Christina Oikonomou, Candace A. Hayes, Chris Melendez-Suchi, Linda M. Hendershot, Linda M. Hendershot   +7 more
doaj   +1 more source

Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

Frontiers in Immunology, 2016
Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend, Julie MJ Laffy, Yu-Chang Bryan Wu, Joselli Silva O'Hare, Victoria Martin, David Kipling, Franca Fraternali, Deborah K Dunn-Walters   +7 more
doaj   +1 more source

Isolation, Production, and Characterization of Serum Immunoglobulin M (IgM) of Indian Major Carp Cirrhinus mrigal (MRIGAL)

Advances in Pharmacological and Pharmaceutical Sciences, 2022
A method for the isolation of immunoglobulin M (IgM) in Indian major carp Cirrhinus mrigal (mrigal) serum to produce polyclonal antibodies is described in the present study.
Prasanna Shama Khandige, K. M. Shankar, P. Suresh Babu, Vandana Sadananda, S. Gowrish   +4 more
doaj   +1 more source

Detection of intracellular IgD using flow cytometry could be a novel and supplementary method to diagnose IgD multiple myeloma

BMC Cancer, 2018
Background We examined whether detecting the heavy chain of cytoplasmic immunoglobulin D (IgD) by flow cytometry could be used as a supplemental method to diagnose IgD multiple myeloma (MM).
Wei Wang, Chun-Xia Zhang, Zhen-Ling Li, Ming Gong, Yi-Gai Ma   +4 more
doaj   +1 more source

Sequence relationships among the variable regions of immunoglobulin heavy chains from various mammalian species.

Proceedings of the National Academy of Sciences of the United States of America, 1972
Immunoglobulin heavy chains of myeloma proteins from dogs and cata have been subjected to automated sequence analysis. When the results were compared with human heavy-chain sequences, all the dog and cat proteins could be unequivocally assigned to the V ...
J. Kehoe, J. Capra
semanticscholar   +1 more source