Longitudinal B Cell Receptor Repertoire Profiling of Heavy- and Light-Chain Features in Injured Rat Spinal Cord Tissue After Traumatic Spinal Cord Injury. [PDF]
Lin T +11 more
europepmc +1 more source
Synovial fluid contains heterogeneous EV populations reflecting stromal and immune‐associated cellular inputs from the arthritic joint. SEC‐UF enrichment coupled to CD90‐targeted immunocapture enables recovery of stromal‐associated EV subpopulation from complex patient synovial fluid, while focused LC‐MS/MS and cell‐of‐origin analysis enable molecular ...
Stefanie Kurth +12 more
wiley +1 more source
Broad targeting of HPV E proteins by intratumoral and systemic B cell responses in HPV+ head and neck cancer. [PDF]
Bahhar I +6 more
europepmc +1 more source
ABSTRACT Tissue‐specific resolution remains a critical barrier in liquid biopsy for precision medicine. To address this, we developed NEXPLOR (Novel EXtracellular vesicle PopuLation Omics Revealer), an immunoaffinity platform enabling selective enrichment of circulating tissue‐specific extracellular vesicles (TS‐EVs), demonstrated here for liver ...
Ricardo Figueiras +9 more
wiley +1 more source
B-cell receptor repertoire remodeling in Kawasaki disease is associated with clonal expansion and distinct repertoire features in coronary artery lesions. [PDF]
Xu Y +6 more
europepmc +1 more source
ABSTRACT Bats have unique immunological characteristics among vertebrates. Understanding how the immune system responds during the life cycle of bat populations is crucial for grasping how their defenses against infection vary during critical life events.
David Alfonso Rivera‐Ruiz +6 more
wiley +1 more source
Long-range allosteric communication within antibodies affects antigen-binding affinity. [PDF]
Vester SK, Sutton BJ, McDonnell JM.
europepmc +1 more source
Blocking Extracellular Cyclophilin A‐Mediated Adhesion Protects Against Bacterial Infection
eCypA promotes bacterial infection by upregulating TGF‐β signaling‐dependent adhesion receptor expression. Pathogens such as IAV, GAS, S. P., and K. P. induce eCypA secretion. Binding of eCypA with TβR2 enhances the affinity of TGF‐β1 and TβR2, which positively regulates adhesion receptors expression via the TGF‐β/Smad signaling pathway, thereby ...
Xiaoyuan Bai +16 more
wiley +1 more source
Anti‐idiotypic antibodies as molecular mimics of conserved influenza hemagglutinin epitopes
Abstract Broadly neutralizing antibodies (bNAbs) provide insights for developing universal influenza vaccines through their ability to neutralize diverse viral strains. However, designing antigens that reliably elicit bNAb responses remains challenging due to the difficulty in targeting conserved epitopes with a single antigen.
Hiroshi Itou +7 more
wiley +1 more source
Beyond the Classical View: Early Emergence of Class Switch Recombination-Associated Molecular Features During B-Cell Development in the Bone Marrow. [PDF]
Hanefioui K, Ashi MO, Guessous F.
europepmc +1 more source

