Results 221 to 230 of about 20,447 (254)
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Lymphokine Control of In Vivo Immunoglobulin Isotype Selection
Annual Review of Immunology, 1990Several specific conclusions can be drawn from these studies: 1. IL-4 is required for the generation of both primary polyclonal and secondary antigen-specific IgE responses in vivo. 2. IL-4 is required to maintain established, ongoing, antigen-specific and polyclonal IgE responses. 3.
F D, Finkelman +9 more
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Models for the dynamics and order of immunoglobulin isotype switching
Bulletin of Mathematical Biology, 2005Experiments show that class switch recombination (CSR) depends on the number of divisions that the cell has performed rather than on the time since stimulation. Using computer simulations of CSR dynamics in B cell populations, we addressed the following questions.
Barak, Yaish, Ramit, Mehr
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Immunoglobulin isotype in the murine response to polysaccharide antigens
European Journal of Immunology, 1983AbstractMurine antisera specific for the α (1→3) and α (1→6)‐linked glucosyl determinants of dextran, as well as for meningococcal polysaccharide group C, have been examined for the distribution of their immunoglobulin classes and subclasses. Whereas the thymus‐independent anti‐α (1→3) dextran response in BALB/c mice was found to be IgM > IgG3 > ...
C, Moreno, J, Esdaile
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Regulation of Isotype Immunoglobulin Production by Adjuvants in Vivo
Scandinavian Journal of Immunology, 1990Mice were immunized against fiuorescein isothiocyanate (FITC)‐labelled human gamma globulin (HGG) or dexlran sulphate (DXS) in the absenee or presence of different adjuvants. The immune response was assayed as the total Ig‐secreting cells and FITC‐speeilic plaque‐forming cells (PFC) found in various lymphoid organs. The adjuvants inliueneed the isolype
E E, Karagouni +1 more
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Monoclonal antibodies against porcine immunoglobulin isotypes
Veterinary Immunology and Immunopathology, 1987Monoclonal antibodies (MCAs) against porcine immunoglobulin isotypes* G, G1, G2, M and A have been produced and characterized in detail. Epitope analysis using a competitive direct enzyme-linked immunosorbent assay (ELISA) indicated that the MCAs recognized 3 class-specific epitopes of IgG, 4 epitopes specific for IgG1, 3 epitopes specific for IgG2, 2 ...
D, Van Zaane, M M, Hulst
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Immunoglobulin isotype knowledge and application to Fc engineering
Current Opinion in Immunology, 2016Monoclonal antibody-based drugs continue to be one of the most rapidly growing classes of therapeutic molecules. At present, the majority of approved therapeutic antibodies are of the human IgG1 format, which can elicit immune effector functions (e.g., antibody-dependent cellular cytotoxicity, antibody-dependent cellular phagocytosis, and complement ...
Randall J, Brezski, George, Georgiou
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Biosynthesis of immunoglobulin isotypes in human periapical lesions
Journal of Endodontics, 1980Periapical lesions from five patients were incubated with radioactive amino acids ( 14 C isoleucine and 14 C lysine). Immunoglobulin synthesis was detected by autoradiography of an immunoelectrophoretic pattern. IgG and IgA were synthesized in vitro by lymphocytes from all of the periapical lesions studied.
O J, Jones, E T, Lally
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In vitro immunoglobulin isotype suppression in immunoglobulin A nephropathy.
Experimental nephrology, 1994IgA nephropathy (IgAN) is characterized by mesangial IgA deposition, and up-regulation of the IgA system is frequently described. This study investigated in vitro immunoglobulin isotype production by peripheral blood mononuclear cells from patients with IgAN and controls, without mitogenic stimulation and under the influence of cell cycle inhibitors ...
A C, Allen +3 more
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Isotypes in Human Immunoglobulin λ-Chains
Nature New Biology, 1971IMMUNOGLOBULIN polypeptide chains consist of a variable N-terminal region and a constant C-terminal part1. The variability of the N-terminal part is due to multiple amino-acid exchanges and deletions, which can be arranged into chemically distinct subgroups2–9.
MAXIME HESS +4 more
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Immunoglobulin isotypes in plasma cells of normal and athymic mice
Cellular Immunology, 1979Abstract The distribution of plasma cells was determined in various lymphoid tissues and exocrine glands of athymic (nude) mice. Compared to values for normal mice, the total number of plasma cells in organs of athymic mice showed a variable decrease as follows: 0%, small intestine; 29%, respiratory tree; 33%, spleen; 50%, lymph nodes; 75%, lactating
Weisz, carrington P +3 more
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