Results 221 to 230 of about 478,815 (317)

Strategy for modular assembly of tetravalent, multispecific antibodies

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette, Levi L. Blazer, Craig A. Hokanson, Chao Chen, Julia Garcia Perez, Alevtina Pavlenco, Lynda Ploder, Alexander U. Singer, Michael D. L. Suits, Sunil Bhakta, Jagath R. Junutula, Jarrett J. Adams, Sachdev S. Sidhu   +12 more
wiley   +1 more source

Reclassification of obstetric antiphospholipid syndrome under the 2023 ACR/EULAR criteria: risk of under-recognition in patients with non-criteria antibodies and clinical implications. [PDF]

Front Med (Lausanne)
Sheng T, Tang Y, Tan Z, Liu L, Dai Q.
europepmc   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, Volume 40, Issue 10, Page 5951-5972, October 2026.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

MOG Antibody in Pregnancy and Breast Milk: An Analysis of 2 Case Reports. [PDF]

Neurol Neuroimmunol Neuroinflamm
Vishnevetsky A, Bilodeau PA, Resnick NE, Levy M.   +3 more
europepmc   +1 more source

Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Coeliac disease (CeD) and immunoglobulin A deficiency (IgAD) frequently co‐occur and share a genetic background within the HLA‐DQ2 region. Although this has been known for decades, the underlying mechanisms linking the two conditions remain unclear.
Kristine Bech, Cæcilie Crawley, Rok Seon Choung, Joseph A. Murray, Steffen Husby   +4 more
wiley   +1 more source

Analysing Antibodies Against Respiratory Viruses in Breast Milk: A Pilot Study. [PDF]

Viruses
Hauan SH, Nundal CH, Lartey Jalloh S, Skudal J, Håskjold EE, Bøe SC, Tøndel C, Sørbye LM, Cox RJ, Brokstad KA.   +9 more
europepmc   +1 more source

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Rapamycin exerts multifaceted immunomodulatory effects in age‐induced atherosclerosis, with pronounced inhibitory effects on adaptive immunity. Rapamycin reduced plaque inflammation and macrophage content, diminished pro‐inflammatory T cell responses, lowered age‐associated B cell frequencies, and attenuated senescence‐associated immune signatures ...
Jill de Mol, Daphne H. de Korte, Marie A. C. Depuydt, Virginia Smit, Mireia N. A. Bernabé Kleijn, Peter J. van Santbrink, Christoph J. Binder, Florentina Porsch, Frank H. Schaftenaar, Amanda C. Foks   +9 more
wiley   +1 more source

Clinical characteristics of IgE deficiency among patients with primary immunodeficiencies: Findings from the United States Immunodeficiency Network (USIDNET) registry. [PDF]

Ann Allergy Asthma Immunol
Jevtic D, Jakubowicz A, Ferastraoaru D.
europepmc   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, Volume 81, Issue 10, Page 3439-3452, October 2026.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

A nested case-control study of monoclonal gammopathy of undetermined significance in the Multiethnic Cohort study. [PDF]

Blood Adv
Salehi M, Wilkens L, Wan JY, Cortessis VK, Stram DO, Conti DV, Aparicio JA, Lam E, Bernstein MP, Desai P, Bertrand KA, Rosenberg AS, Lee L, Le Marchand L, Haiman CA, Emerson J, Cozen W.   +16 more
europepmc   +1 more source