Results 251 to 260 of about 478,815 (317)

Monoclonal antibodies against porcine immunoglobulin isotypes.

Veterinary Immunology and Immunopathology, 1987
Monoclonal antibodies (MCAs) against porcine immunoglobulin isotypes* G, G1, G2, M and A have been produced and characterized in detail. Epitope analysis using a competitive direct enzyme-linked immunosorbent assay (ELISA) indicated that the MCAs recognized 3 class-specific epitopes of IgG, 4 epitopes specific for IgG1, 3 epitopes specific for IgG2, 2 ...
D. V. van Zaane, M. Hulst
semanticscholar   +3 more sources

Reduction chemistry-assisted nanopore determination method for immunoglobulin isotypes.

Nanoscale, 2020
Immunoglobulins can bind to an unlimited array of foreign antigens presented to the immune system. Among those isotypes, IgG and IgM play crucial roles in initial immune defense associated with innate immunity factors. Hence, the determination of IgG and
Qian-Shan Liu, Yun-Jiao Wang, Ya-Qing Liu, Hanqing Wang, Wei Li, Peng Tang, Ting Weng, Shuo Zhou, Li-Yuan Liang, Jiahu Yuan, De-Qiang Wang, Liang Wang   +11 more
semanticscholar   +1 more source

Monoclonal Antibodies to Murine Immunoglobulin Isotypes

Hybridoma, 1983
We have obtained cell lines producing monoclonal antibodies against mu, alpha, lambda, and lambda 1 by fusing the mouse myeloma P3X63Ag8.653 with spleen cells from Lewis rats immunized with several lambda 1 bearing myeloma proteins. The anti-lambda 1 antibody is particularly useful.
S, Weiss, K, Lehmann, M, Cohn
openaire   +2 more sources

Immunoglobulin Isotype Expression

1978
Many different kinds of observations suggest that during development of the B cell line, individual V H genes determining the antibody specificity of an immunoglobulin molecule can be expressed with multiple C H genes. Thus each clone of B cells, defined by expression of a variable-region gene for the light and heavy chains of the immunoglobulin ...
J F, Kearney, E R, Abney
openaire   +2 more sources

Isoelectric restriction of human immunoglobulin isotypes

Biochimica et Biophysica Acta (BBA) - General Subjects, 1995
The partition of human serum immunoglobulins along a pH gradient of ampholynes was investigated using the recently developed method of preparative isoelectrofocusing. Each isotype was demonstrated to display a specific pI range, with limited overlapping. IgA appear to be the most acidic serum immunoglobulins while IgG are clearly basic.
C, Prin, M C, Bene, B, Gobert, P, Montagne, G C, Faure   +4 more
openaire   +2 more sources

Allotypic and isotypic aspects of human immunoglobulin A

Molecular Immunology, 1983
The location of isotypic, isoallotypic and allotypic determinants is reviewed in the light of data obtained when specific antisera are tested with proteolytic fragments of IgA molecules or mutants of IgA obtained from patients with alpha-heavy chain disease. Isotypic determinants are distributed throughout the alpha chain constant regions although when
E, van Loghem, J, Biewenga
openaire   +2 more sources

Immunoglobulin isotype switching in xid mice

Molecular Immunology, 1995
Mice with the x-linked immunodeficiency mutation (xid) are unresponsive to polysaccharide antigens, lack a subset of B cells, and have low serum IgM (2-20% of normal) and IgG3 (3% of normal). Because of the disproportionate reduction of IgG3, the ability of B cells from xid mice to switch to gamma 3 was examined.
K A, Brorson, M V, Krasnokutsky, K E, Stein   +2 more
openaire   +2 more sources

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993
Publisher Summary This chapter focuses on the molecular mechanisms of switch recombination and other possible modes of isotype switching. It discusses the regulation of isotype switching, especially by T cells and the cytokines they produce. Virtually all of the analyses of the mechanisms and regulation of switching are done in either mouse or human,
R L, Coffman, D A, Lebman, P, Rothman
openaire   +2 more sources

The Isotypic Circuit: Immunoglobulins, Fc Receptors and Immunoglobulin Binding Factors

International Reviews of Immunology, 1987
(1987). The Isotypic Circuit: Immunoglobulins, Fc Receptors and Immunoglobulin Binding Factors. International Reviews of Immunology: Vol. 2, No. 2, pp. 221-240.
W H, Fridman, J L, Teillaud, S, Amigorena, M, Daëron, U, Blank, C, Néauport-Sautès   +5 more
openaire   +2 more sources

Normal distribution of immunoglobulin isotypes in adult horses

The Veterinary Journal, 2009
Studies focusing on the equine humoral response are scarce, with a bias towards the pre- and post-parturition mare and its foal. The present study attempted to expand current knowledge by establishing normal ranges for adult horse serum isotypes. Immunoglobulin (Ig) concentrations were obtained by screening 47 horses of various breeds and in different ...
Maristela M, de Camargo, Juliana S, Kuribayashi, Cíntia R, Bombardieri, Alma, Hoge   +3 more
openaire   +2 more sources