Results 121 to 130 of about 37,394 (238)

Rapid hematologic responses improve outcomes in patients with very advanced (stage IIIb) cardiac immunoglobulin light chain amyloidosis

Haematologica, 2018
Systemic AL amyloidosis (AL) is caused by deposition of misfolded immunoglobulin light chains, leading to potentially catastrophic visceral dysfunction.[1][1] Outcomes are heterogeneous, but cardiac involvement is a key survival predictor.
R. Manwani, Darren Foard, S. Mahmood, S. Sachchithanantham, T. Lane, C. Quarta, T. Youngstein, T. Rezk, H. Lachmann, J. Gillmore, M. Fontana, C. Whelan, P. Hawkins, A. Wechalekar   +13 more
semanticscholar   +1 more source

Multiple Myeloma Presenting as Lower Gastrointestinal Bleeding: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Multiple myeloma (MM) is a malignant hematologic neoplasm that primarily affects the bone marrow and can invade other organs, leading to diverse clinical manifestations. Presentation with gastrointestinal bleeding as the initial symptom is exceptionally rare.
Ahmed Arabi, Naseem Ambra, Asgad Mohamed Ahmed Eltigani, Asma Ahmed Yousif, Abdelkarim Hashim Mohamed   +4 more
wiley   +1 more source

Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma [PDF]

, 2019
The diagnosis of primary systemic amyloidosis, also known as AL (amyloid light-chain) amyloidosis, is often delayed owing to its nonspecific manifestations as well as its rarity.
Behrens, Emily, Tan, Kendra W, Tarbox, Michelle B, Zhu, Brian   +3 more
core  

PLA2R‐Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Betelhem Abreham, Leja Hamza, Azeb Kebede, Daniel Rebuma Bekele, Zekarias Amdemariam   +4 more
wiley   +1 more source

Pulmonary light chain deposition disease: Case series and review of the literature

Radiology Case Reports
Pulmonary light chain deposition disease is a rare entity characterized by immunoglobulin deposition within the lung parenchyma with pathologic features distinct from pulmonary amyloidosis.
Tomas V. Gonzalez, MD, Anja C. Roden, MD, Brian J. Bartholmai, MD, Rebecca M. Lindell, MD   +3 more
doaj   +1 more source

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]

, 2017
The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J., Pringle, Marie Anne, Robinson, Philip J., Woolhead, Cheryl A.   +3 more
core   +1 more source

Impact of Induction Therapy on the Outcome of Immunoglobulin Light Chain Amyloidosis after Autologous Hematopoietic Stem Cell Transplantation.

Biology of Blood and Marrow Transplantation, 2018
With the availability of immunomodulatory imide drugs (IMiDs) and proteasome inhibitors (PI), most patients with immunoglobulin light chain amyloidosis (AL) receive induction therapy before autologous hematopoietic stem cell transplantation (auto-HCT ...
A. Afrough, R. Saliba, A. Hamdi, Medhavi Honhar, A. Varma, A. Cornelison, G. Rondon, S. Parmar, N. Shah, Q. Bashir, C. Hosing, U. Popat, D. Weber, S. Thomas, R. Orlowski, R. Champlin, M. Qazilbash   +16 more
semanticscholar   +1 more source

Survival and Renal Recovery in Newly Diagnosed Multiple Myeloma Patients Presenting With Dialysis‐Requiring Severe Renal Impairment

European Journal of Haematology, Volume 116, Issue 5, Page 577-584, May 2026.
ABSTRACT Background Severe renal insufficiency requiring dialysis in newly diagnosed multiple myeloma (NDMM) patients has been independently associated with poor survival outcomes. However, there is a paucity of data on factors predicting renal recovery and survival outcomes of these patients.
Rintu Sharma, Eshetu G. Atenafu, Esther Masih‐Khan, Harjot Vohra, Sita Bhella, Christine Chen, Vishal Kukreti, Guido Lancman, Anca Prica, A. Keith Stewart, Rodger Tiedemann, Suzanne Trudel, Chloe Yang, Donna Reece   +13 more
wiley   +1 more source

Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis [PDF]

, 2018
Introduction: Renal biopsy series from North America suggest that leucocyte chemotactic factor 2 (ALECT2) amyloid is the third most common type of renal amyloid. We report the first case series from a European Centre of prevalence, clinical presentation
Bass, P, Fontana, M, Gilbertson, JA, Gillmore, JD, Hawkins, PN, Lachmann, HJ, Mahmood, S, Rendell, N, Rezk, T, Rowczenio, D, Sachchithanantham, S, Taylor, GW, Wechalekar, AD, Whelan, CJ, Wong, J   +14 more
core  

Monoclonal gammopathy of undetermined significance : natural course and comorbidities [PDF]

, 2017
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder characterized by an overproduction of monoclonal immunoglobulins.
Lindqvist, Ebba K
core   +1 more source