Results 61 to 70 of about 14,209 (224)

Immunoglobulin Light-Chain Amyloidosis: Clinical Presentations and Diagnostic Approach. [PDF]

J Adv Pract Oncol, 2019
Systemic immunoglobulin light-chain (AL) amyloidosis is a rare disorder arising from a plasma cell clone that produces misfolded immunoglobulin light chains, which are deposited in various tissues and organs as amyloid fibrils. Signs and symptoms are typically vague and overlap with those arising from other common diseases; consequently, diagnosis of ...
Hwa YL, Fogaren T, Sams A, Faller DV, Stull DM, Thuenemann S, Mendelson L.   +6 more
europepmc   +5 more sources

Activity of pomalidomide in patients with immunoglobulin light-chain amyloidosis [PDF]

Blood, 2012
Abstract Immunoglobulin light-chain (AL) amyloidosis is a rare, incurable plasma cell disorder. Its therapy has benefited immensely from the expanding drug armamentarium available for multiple myeloma. Pomalidomide in combination with weekly dexamethasone (Pom/dex) is active among patients with relapsed myeloma.
David Dingli, Vivek Roy, Craig B. Reeder, Francis K. Buadi, Kristina Laumann, S. Vincent Rajkumar, Robert E. Hall, Betsy LaPlant, Morie A. Gertz, Thomas E. Witzig, Angela Dispenzieri, Martha Q. Lacy, Joseph R. Mikhael, P. Lief Bergsagel, Stephen J. Russell, A. Keith Stewart, Shaji Kumar, Steven R. Zeldenrust, John A. Lust, Suzanne R. Hayman, Rafael Fonseca   +20 more
openaire   +3 more sources

A stepwise data interpretation process for renal amyloidosis typing by LMD-MS

BMC Nephrology, 2022
Backgrounds Systemic amyloidosis is classified according to the deposited amyloid fibril protein (AFP), which determines its best therapeutic scheme. The most common type of AFP found are immunoglobulin light chains.
Ming Ke, Xin Li, Lin Wang, Shuling Yue, Beibei Zhao   +4 more
doaj   +1 more source

Gastrointestinal Amyloidosis: Diagnostic Approach and Treatment [PDF]

, 2015
Amyloidosis is a disease marked by deposition of misfolded proteins, known as amyloids, in the extracellular space, including gastrointestinal tract.
Budyono, C. (Catarina), Fauzi, A. (Achmad), Makmun, D. (Dadang)   +2 more
core   +2 more sources

Concurrent light chain amyloidosis and proximal tubulopathy: Insights into different aggregation behavior—A case report

eJHaem, 2022
Due to differences in the protein folding mechanisms, it is exceedingly rare for amyloid light chain (AL) amyloidosis and monoclonal gammopathy of renal significance (MGRS) to coexist.
Simone Feurstein, Julian Zoller, Constantin Schwab, Sarah Schreiner, Heiko Mundt, Iris Breitkreutz, Brigitte Schneider, Jörg Beimler, Martin Zeier, Rüdiger Waldherr, Stefan Gröschel, Carsten Müller‐Tidow, Stefan O. Schönland, Ute Hegenbart   +13 more
doaj   +1 more source

Cardiac Amyloidosis: Clinical Features, Pathogenesis, Diagnosis, and Treatment [PDF]

Türk Patoloji Dergisi
Cardiac amyloidosis is a type of amyloidosis that deserves special attention as organ involvement significantly worsens the prognosis. Cardiac amyloidosis can be grouped under three main headings: immunoglobulin light chain (AL) amyloidosis that is ...
Asuman ARGON, Deniz NART, Funda YILMAZ BARBET   +2 more
doaj   +1 more source

Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2018. [PDF]

Blood Cancer J, 2018
AbstractImmunoglobulin light chain amyloidosis (AL) should be considered in any patient that presents to a cancer care provider with nephrotic range proteinuria, heart failure with preserved ejection fraction, non-diabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea.
Gertz MA.
europepmc   +5 more sources

Breast amyloidosis: a case report [PDF]

, 2016
Amyloidosis is an uncommon disorder characterized by extracellular deposition of abnormal proteins. Breast involvement has rarely been reported and can clinically be misdiagnosed as breast cancer.
Boscaini, Giulia, DE SANTIS, Giorgio, Pignatti, Marco, Tazzioli, Giovanni   +3 more
core   +1 more source

Germ line origin and somatic mutations determine the target tissues in systemic AL-amyloidosis. [PDF]

PLoS ONE, 2007
BACKGROUND: Amyloid is insoluble aggregated proteins deposited in the extra cellular space. About 25 different proteins are known to form amyloid in vivo and are associated with severe diseases such as Alzheimer's disease, prion diseases and type-2 ...
Stina Enqvist, Knut Sletten, Fred J Stevens, Ulf Hellman, Per Westermark   +4 more
doaj   +1 more source

Incidence and survival in non-hereditary amyloidosis in Sweden [PDF]

, 2012
BACKGROUND: Amyloidosis is a heterogeneous disease caused by deposition of amyloid fibrils in organs and thereby interfering with physiological functions.
Asta Försti, Jan Sundquist, Kari Hemminki, Kristina Sundquist, Xinjun Li   +4 more
core   +1 more source