Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains [PDF]
BMC Biology, 2023 Background In a range of human disorders such as multiple myeloma (MM), immunoglobulin light chains (IgLCs) can be produced at very high concentrations. This can lead to pathological aggregation and deposition of IgLCs in different tissues, which in turn
Rebecca Sternke-Hoffmann +19 more
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Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain [PDF]
eLife, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Boris Brumshtein +7 more
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Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish [PDF]
iScience, 2021 Summary: B cells express a unique antibody protein which comprises two pairs of immunoglobulin (Ig) heavy (H) and light (L) chains. In addition to an invariable constant (C) region, IgH and IgL chains encompass a variable (V) region mediating antigen ...
Pedro Perdiguero +3 more
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Human Autoantibody Silencing by Immunoglobulin Light Chains [PDF]
The Journal of Experimental Medicine, 2004 Several newly arising human antibodies are polyreactive, but in normal individuals the majority of these potentially autodestructive antibodies are removed from the repertoire by receptor editing or B cell deletion in the bone marrow.
Hammersen, Johanna +2 more
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Chromogenic in situ hybridization for the detection of lambda and kappa immunoglobulin light chains as a potential auxiliary diagnostic technique in canine plasmacytomas. [PDF]
J Vet Diagn Invest, 2020 The heterogeneous morphologic features of canine plasmacytomas (PCTs) can make their differentiation from other round cell tumors challenging. Immunohistochemistry (IHC) for lambda (\u3bb) and kappa (\u43a) immunoglobulin (Ig) light chains is often ...
Foiani G +6 more
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Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection [PDF]
Viruses, 2019 Rapid point-of-care testing is a megatrend in infectious disease diagnosis. We have introduced a homogeneous immunoassay concept, which is based on the simultaneous binding of antigen and protein L to a given immunoglobulin molecule.
Satu Hepojoki +9 more
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Immunoglobulin light chains in medaka (Oryzias latipes). [PDF]
Immunogenetics, 2013 The gene segments encoding antibodies have been studied in many capacities and represent some of the best-characterized gene families in traditional animal disease models (mice and humans). To date, multiple immunoglobulin light chain (IgL) isotypes have been found in vertebrates and it is unclear as to which isotypes might be more primordial in nature.
Magadán-Mompó S +3 more
europepmc +6 more sources
Heavy and light chains of a homogeneous immunoglobulin‐G [PDF]
FEBS Letters, 1969 Zuhayr L. Awdeh +2 more
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Systematic characterization of immunoglobulin loci and deep sequencing of the expressed repertoire in the Atlantic cod (Gadus morhua) [PDF]
BMC GenomicsBackground The Atlantic cod is a prolific species in the Atlantic, despite its inconsistent specific antibody response. It presents a peculiar case within vertebrate immunology due to its distinct immune system, characterized by the absence of MHCII ...
Ádám Györkei +2 more
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Different roles of urinary light chains and serum light chains as potential biomarkers for monitoring disease activity in systemic lupus erythematosus [PDF]
PeerJ, 2022 Objective The assessment system for monitoring systemic lupus erythematosus (SLE) disease activity is complex and lacks reliable laboratory indicators. It is necessary to find rapid and noninvasive biomarkers.
Jun Jiang, Jin Zhao, Dan Liu, Man Zhang
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