Results 1 to 10 of about 46,310 (42)

Higher Serum Levels of Free ĸ plus λ Immunoglobulin Light Chains Ameliorate Survival of Hemodialysis Patients [PDF]

, 2011
<i>Background/Aims:</i> Impaired immune function is common in patients with chronic renal failure. Now, we determined whether serum levels of free immunoglobulin light chains predict mortality in patients with chronic kidney disease stage 5 ...
Caspari, Christina, Scholze, Alexandra, Tepel, Martin, Thilo, Florian   +3 more
core   +1 more source

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Denecke, J. (Jurgen), Frigerio, Lorenzo, Hadlington, Jane L., Ma, Julian K.-C., Nuttall, James, Santoro, Aniello, Vitale, A. (Alessandro)   +6 more
core   +2 more sources

Diversity of immunoglobulin light chain genes in non-teleost ray-finned fish uncovers IgL subdivision into five ancient isotypes [PDF]

, 2018
The aim of this study was to fill important gaps in the evolutionary history of immunoglobulins by examining the structure and diversity of IgL genes in non-teleost ray-finned fish.
Andreyushkova, Daria A, Baranov, Konstantin O, Chikaev, Nikolai A, Gessner, Jörn, Guselnikov, Sergey V, Kulemzin, Sergey V, Makunin, Alexey I, Mechetina, Ludmila V, Najakshin, Alexander M, Schartl, Manfred, Stöck, Matthias, Taranin, Alexander V, Trifonov, Vladimir A, Warren, Wesley C, Wuertz, Sven   +14 more
core   +5 more sources

Cerebrospinal Fluid Analysis in Multiple Sclerosis Diagnosis: An Update [PDF]

, 2019
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) with brain neurodegeneration. MS patients present heterogeneous clinical manifestations in which both genetic and environmental factors are involved ...
Bruna Lo Sasso, Chiara Bellia, Giulia Bivona, Luisa Agnello, Marcello Ciaccio   +4 more
core   +1 more source

The Immunoglobulins of Cold-Blooded Vertebrates [PDF]

, 2014
Peer reviewedPublisher ...
Chen, Clem, Cone, Cooper, Crouch, Deza, Grey, Hadji-Azimi, Hsu, Kokubu, Leslie, Magor, Malecek, Mansikka, Patel, Schaerlinger, Schaerlinger, Small, Steiner, Turchin, Wilson, Wu, Zapata   +22 more
core   +2 more sources

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source

Pre-B-cell development in the absence of λ5 in transgenic mice expressing a heavy-chain disease protein [PDF]

, 1995
Background: Heavy-chain diseases (HCDs) are human lymphoproliferative neoplasias that are characterized by the secretion of truncated immunoglobulin heavy chains devoid of light chains.
Bucchini, Danielle, Butor, Cécile, Cesbron, Jean-Yves, Corcos, Daniel, Dunda, Olga, Jami, Jacques, Lorès, Patrick   +6 more
core   +1 more source

Evolution of antigen binding receptors [PDF]

, 1999
This review addresses issues related to the evolution of the complex multigene families of antigen binding receptors that function in adaptive immunity.
Anderson, Michele K., Litman­, Gary W., Rast­, ­Jonathan P.   +2 more
core   +1 more source

B cell receptor accessory molecule CD79α : characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias) [PDF]

, 2013
Copyright © 2013.
Anderson, Bhargava, Bird, Bodine, Browne, Cambier, Campanella, Campbell, Campbell, Christopher J. Secombes, DeFranco, Dooley, Dooley, Dylke, Eason, Eckner, Engels, Fitzsimmons, Flajnik, Flajnik, Guselnikov, Ha, Hagman, Haire, Haman, Hardy, Heinemeyer, Helen Dooley, Hinds, Ito, Jang, Johnson, Jun Zou, Kabak, Kahsay, Kashiwamura, Larkin, Lee, Li, Luisiri, Lukin, Malecek, Mason, Minegishi, Miracle, Mount, Neuberger, Patterson, Petersen, Pfaffl, Pryjma, Rast, Ravi, Reddick, Reth, Reth, Reth, Roessler, Ronggai Li, Rumfelt, Sahoo, Sakaguchi, Salim, Sanchez, Sigrist, Sigvardsson, Smith, Steinke, Steve Bird, Tamura, Tiehui Wang, Travis, Volff, Walsh, Wang, Williams, Youn, Youn, Yu   +78 more
core   +2 more sources