Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains [PDF]
BMC Biology, 2023 Background In a range of human disorders such as multiple myeloma (MM), immunoglobulin light chains (IgLCs) can be produced at very high concentrations. This can lead to pathological aggregation and deposition of IgLCs in different tissues, which in turn
Rebecca Sternke-Hoffmann +19 more
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Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains. [PDF]
Biochemistry, 2019 Little is known about the mechanism of amyloid assembly in immunoglobulin light chain (AL) amyloidosis, in contrast to other amyloid diseases. Early events in the aggregation pathway are especially important, as these soluble species could be cytotoxic ...
Misra P +2 more
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Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. [PDF]
J Clin Invest, 2019 Because of the less-than-robust response to therapy and impact on choice of optimal chemotherapy and prognosis, chronic kidney disease has drawn attention in the treatment of multiple myeloma, a malignant hematologic disorder that can produce significant
Ying WZ +5 more
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Stabilization of amyloidogenic immunoglobulin light chains by small molecules. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance Light-chain amyloidosis (AL) is a progressive and often fatal degenerative disease caused by conformational changes within Ig light chains that generally lead to aggregation. Current chemotherapy treatments aim to eliminate the clonal plasma
Morgan GJ +15 more
europepmc +2 more sources
The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation. [PDF]
Sci Rep, 2019 Immunoglobulin light chain-derived (AL) amyloidosis is a debilitating disease without known cure. Almost nothing is known about the structural factors driving the amyloidogenesis of the light chains.
Ruiz-Zamora RA +13 more
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Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish [PDF]
iScience, 2021 Summary: B cells express a unique antibody protein which comprises two pairs of immunoglobulin (Ig) heavy (H) and light (L) chains. In addition to an invariable constant (C) region, IgH and IgL chains encompass a variable (V) region mediating antigen ...
Pedro Perdiguero +3 more
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Role of domain interactions in the aggregation of full-length immunoglobulin light chains. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance The misfolding and/or aggregation of proteins can give rise to amyloid diseases, including immunoglobulin light-chain (LC) amyloidosis, leading to large proteinaceous deposits in organs throughout the body.
Rennella E, Morgan GJ, Kelly JW, Kay LE.
europepmc +2 more sources
Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity. [PDF]
Sci Rep, 2017 Light chain amyloidosis (AL), the most common systemic amyloidosis, is caused by the overproduction and the aggregation of monoclonal immunoglobulin light chains (LC) in target organs.
Oberti L +9 more
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Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. [PDF]
PLoS ONE, 2009 The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain ...
Tanya L Poshusta +5 more
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Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains. [PDF]
Sci Rep, 2017 Antibody light chain amyloidosis is a rare disease caused by fibril formation of secreted immunoglobulin light chains (LCs). The huge variety of antibody sequences puts a serious challenge to drug discovery.
Hora M +7 more
europepmc +2 more sources