Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain [PDF]
eLife, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Boris Brumshtein +7 more
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Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate. [PDF]
J Biol Chem, 2017 Intervention into amyloid deposition with anti-amyloid agents like the polyphenol epigallocatechin-3-gallate (EGCG) is emerging as an experimental secondary treatment strategy in systemic light chain amyloidosis (AL). In both AL and multiple myeloma (MM),
Andrich K +7 more
europepmc +2 more sources
Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection [PDF]
Viruses, 2019 Rapid point-of-care testing is a megatrend in infectious disease diagnosis. We have introduced a homogeneous immunoassay concept, which is based on the simultaneous binding of antigen and protein L to a given immunoglobulin molecule.
Satu Hepojoki +9 more
doaj +2 more sources
Медицинская иммунология, 2015 Increased intrathecal synthesis and oligoclonal banding of immunoglobulins (Ig) in cerebrospinal fluid (CSF) are major immunological findings in multiple sclerosis.
V. D. Nazarov +5 more
doaj +3 more sources
A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains [PDF]
Journal of Mass Spectrometry and Advances in the Clinical LabBackground: Detecting and monitoring monoclonal free light immunoglobulin chains in serum is important for managing patients with B-cell neoplasms. Established methods have relied on immunochemistry, with monoclonality determined through an abnormal ...
Per Bengtson, Magnus Förnvik Jonsson
doaj +2 more sources
A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains. [PDF]
Eur J Med Res, 2021 Matsuoka R +4 more
europepmc +3 more sources
Amyloidogenicity of Immunoglobulin Light Chains [PDF]
, 2015 Kathrin Andrich +4 more
openalex +2 more sources
Different roles of urinary light chains and serum light chains as potential biomarkers for monitoring disease activity in systemic lupus erythematosus [PDF]
PeerJ, 2022 Objective The assessment system for monitoring systemic lupus erythematosus (SLE) disease activity is complex and lacks reliable laboratory indicators. It is necessary to find rapid and noninvasive biomarkers.
Jun Jiang, Jin Zhao, Dan Liu, Man Zhang
doaj +2 more sources
Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?
Antibodies, 2022 When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells.
Siqi Gong +4 more
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Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +2 more sources