Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain [PDF]
eLife, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Boris Brumshtein +7 more
doaj +3 more sources
Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?
Antibodies, 2022 When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells.
Siqi Gong +4 more
doaj +1 more source
Solitary ulcerated plaque on the face - an unusual presentation of cutaneous plasmacytosis? [PDF]
Anais Brasileiros de Dermatologia, 2017 Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy.
Ana Marta António +3 more
doaj +1 more source
Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis
Hemato, 2021 Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in ...
Gareth J. Morgan +2 more
doaj +1 more source
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
doaj +1 more source
Immunoglobulin light chain amyloid aggregation [PDF]
Chemical Communications, 2018 Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding disease.
Luis M. Blancas-Mejia +8 more
openaire +2 more sources
Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. [PDF]
PLoS ONE, 2009 The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain ...
Tanya L Poshusta +5 more
doaj +1 more source
Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis
Hemato, 2022 The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and organ dysfunction. Clinical and experimental advances have cast new light on the pathophysiology of damage in AL amyloidosis.
Francesca Lavatelli
doaj +1 more source
Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease [PDF]
, 2012 Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes ...
Barreto, Daniela V +9 more
core +8 more sources
مجله دانشکده پزشکی اصفهان, 2018 Background: Non-Hodgkin lymphoma is the most common cancer in the world. This study aimed to determine the correlation between the serum level of free light chain ratio and age, and subtype and stage of the disease.
Farzaneh Ashrafi +2 more
doaj +1 more source