Results 21 to 30 of about 258,914 (247)

Solitary ulcerated plaque on the face - an unusual presentation of cutaneous plasmacytosis? [PDF]

Anais Brasileiros de Dermatologia, 2017
Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy.
Ana Marta António, João Vitor Alves, Ricardo Coelho, Elvira Bártolo   +3 more
doaj   +1 more source

Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis

Hemato, 2021
Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in ...
Gareth J. Morgan, Joel N. Buxbaum, Jeffery W. Kelly   +2 more
doaj   +1 more source

Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]

PLoS ONE, 2014
Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita, Akiko Sano, Hua Wu, Jin-An Jiao, Poothappillai Kasinathan, Eddie J Sullivan, Zhongde Wang, Yoshimi Kuroiwa   +7 more
doaj   +1 more source

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis.

New England Journal of Medicine, 2021
BACKGROUND Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting antibody, may improve outcomes for this disease.
E. Kastritis, G. Palladini, M. Minnema, A. Wechalekar, A. Jaccard, Hans C. Lee, V. Sanchorawala, S. Gibbs, P. Mollee, C. Venner, Jin-Hai Lu, S. Schönland, M. Gatt, Kenshi Suzuki, Kihyun Kim, M. Cibeira, M. Beksaç, E. Libby, J. Valent, V. Hungria, S. Wong, M. Rosenzweig, N. Bumma, A. Huart, M. Dimopoulos, D. Bhutani, A. Waxman, S. Goodman, J. Zonder, Selay Lam, K. Song, T. Hansen, S. Manier, W. Roeloffzen, K. Jamroziak, F. Kwok, C. Shimazaki, Jin-Seok Kim, E. Crusoé, T. Ahmadi, N. Tran, X. Qin, S. Vasey, B. Tromp, J. Schecter, B. Weiss, S. Zhuang, J. Vermeulen, G. Merlini, R. Comenzo   +49 more
semanticscholar   +1 more source

Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis

Hemato, 2022
The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and organ dysfunction. Clinical and experimental advances have cast new light on the pathophysiology of damage in AL amyloidosis.
Francesca Lavatelli
doaj   +1 more source

Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease [PDF]

, 2012
Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes ...
Barreto, Daniela V, Barreto, Fellype C, Eloot, Sunny, Glorieux, Griet, Lemke, Horst D, Lenglet, Aurélie, Liabeuf, Sophie, Massy, Ziad A, Neirynck, Nathalie, Vanholder, Raymond   +9 more
core   +8 more sources

The Correlation between the Serum Level of Free Light Chain Ratio and Prognostic Factors among the Patients with Lymphoma

مجله دانشکده پزشکی اصفهان, 2018
Background: Non-Hodgkin lymphoma is the most common cancer in the world. This study aimed to determine the correlation between the serum level of free light chain ratio and age, and subtype and stage of the disease.
Farzaneh Ashrafi, Seyyed Amirabbas Nekouei, Elham Moazzam   +2 more
doaj   +1 more source

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma

Journal of Cell Biology, 1975
Fractionation of MOPC 41 DL-1 tumors revealed that the mRNA for the light chain of immunoglobulin is localized exclusively in membrane- bound ribosomes.
G. Blobel, B. Dobberstein
semanticscholar   +1 more source

Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

Nature Communications, 2021
In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs.
Maura Garofalo, L. Piccoli, Margherita Romeo, M. M. Barzago, Sara Ravasio, Mathilde Foglierini, M. Matković, Jacopo Sgrignani, R. De Gasparo, M. Prunotto, L. Varani, L. Diomede, O. Michielin, A. Lanzavecchia, A. Cavalli   +14 more
semanticscholar   +1 more source

Higher Serum Levels of Free ĸ plus λ Immunoglobulin Light Chains Ameliorate Survival of Hemodialysis Patients [PDF]

, 2011
<i>Background/Aims:</i> Impaired immune function is common in patients with chronic renal failure. Now, we determined whether serum levels of free immunoglobulin light chains predict mortality in patients with chronic kidney disease stage 5 ...
Caspari, Christina, Scholze, Alexandra, Tepel, Martin, Thilo, Florian   +3 more
core   +1 more source