Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection [PDF]
Viruses, 2019 Rapid point-of-care testing is a megatrend in infectious disease diagnosis. We have introduced a homogeneous immunoassay concept, which is based on the simultaneous binding of antigen and protein L to a given immunoglobulin molecule.
Satu Hepojoki +9 more
doaj +2 more sources
Immunoglobulin free light chains are increased in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2011 BACKGROUND: Idiopathic pulmonary fibrosis (IPF), a devastating lung disorder of unknown aetiology, and chronic hypersensitivity pneumonitis (HP), a disease provoked by an immunopathologic reaction to inhaled antigens, are two common interstitial lung ...
Tom Groot Kormelink +7 more
doaj +2 more sources
Heavy and light chains of a homogeneous immunoglobulin‐G [PDF]
FEBS Letters, 1969 Zuhayr L. Awdeh +2 more
openalex +5 more sources
Structural repertoire of immunoglobulin λ light chains
Proteins: Structure, Function, and Bioinformatics, 2011 The immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions ...
Anna Chailyan +3 more
semanticscholar +6 more sources
Different roles of urinary light chains and serum light chains as potential biomarkers for monitoring disease activity in systemic lupus erythematosus [PDF]
PeerJ, 2022 Objective The assessment system for monitoring systemic lupus erythematosus (SLE) disease activity is complex and lacks reliable laboratory indicators. It is necessary to find rapid and noninvasive biomarkers.
Jun Jiang, Jin Zhao, Dan Liu, Man Zhang
doaj +2 more sources
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +2 more sources
Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?
Antibodies, 2022 When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells.
Siqi Gong +4 more
doaj +1 more source
Solitary ulcerated plaque on the face - an unusual presentation of cutaneous plasmacytosis? [PDF]
Anais Brasileiros de Dermatologia, 2017 Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy.
Ana Marta António +3 more
doaj +1 more source
Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis
Hemato, 2021 Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in ...
Gareth J. Morgan +2 more
doaj +1 more source
Amyloidogenicity of Immunoglobulin Light Chains [PDF]
Biophysical Journal, 2015 Systemic light chain amyloidosis (AL) is a rare protein aggregation disease. It usually strikes in the wake of myeloma, which affects plasma cells in the adaptive immune system. During plasma cell development, the immunoglobulin light chain (LC) genes undergo several rearrangements that leave each clone with a unique protein sequence.
Kathrin Andrich +4 more
openaire +2 more sources