Results 71 to 80 of about 411,227 (271)

Evolution and Mutations of Beta 2 Microglobulin [PDF]

arXiv, 2022
Here we examine the evolution of beta-2 microglobulin in terms of its hydropathic shapes, a theoretical construct that has revealed important trends. The dynamics of many proteins are largely driven by interactions between the protein itself and the thin water film that covers it.
arxiv  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Evaluation of Serological Tests Using A60 Antigen for Diagnosis of Tuberculosis [PDF]

Acta Medica Iranica, 2010
Identification of acid-fast bacilli (AFB) in sputum or tissue samples is among definite diagnostic methods of tuberculosis. However, this method of diagnosis is restricted by certain limitations.
Hamid Emadi Kochak, Seyed Ahmad SeyedAlinaghi, Omid Zarghom, Shadi Hekmat, Sara Jam, Duman Sabzvari, Zahra Abdi   +6 more
doaj   +1 more source

Mutations Affecting the Structure and Function of Immunoglobulin M [PDF]

Molecular and Cellular Biology, 1982
Using a hybridoma cell line which secretes hapten-specific immunoglobulin M (IgM), we have isolated a variety of mutants which produce abnormal immunoglobulin. Immunoglobulin was tested for the size and composition of the component heavy and light chains and for variable and constant region related functional and serological activities.
G Köhler, M J Shulman, C Filkin, C Heusser   +3 more
openaire   +3 more sources

Kinetic characterization of amino acid activation by aminoacyl‐tRNA synthetases using radiolabelled γ‐[32P]ATP

FEBS Open Bio, EarlyView.
Activation of amino acids by aminoacyl‐tRNA synthetases can be followed by a modified ATP/PPi exchange assay using radiolabelled γ‐[32P]ATP. The reaction is quenched at certain time points, followed by separation of the product ([32P]PPi) from the substrate (γ‐[32P]ATP) by thin‐layer chromatography (TLC).
Igor Živković, Morana Dulic, Petra Kozulic, Marko Mocibob, Ita Gruic‐Sovulj   +4 more
wiley   +1 more source

Influência do tipo de parto sobre a concentração de imunoglobulinas A, G e M no colostro materno Influence of type of delivery on A, G and M immunoglobulin concentration in maternal colostrum

Jornal de Pediatria, 2004
OBJETIVO: Verificar a influência do tipo de parto sobre a concentração das imunoglobulinas (Ig) A, G e M no colostro materno. MÉTODOS: Foram selecionadas 82 puérperas com idade cronológica entre 21 e 41 anos, idade gestacional de 37 ou mais semanas ...
Gabriel A. J. Striker, Lucy D. Casanova, Aparecida Tiemi Nagao   +2 more
doaj   +1 more source

Immunity to Plasmodium knowlesi H strain malaria in olive baboons [PDF]

Int. J. Integ. Biol. Volume 10, Issue No. 3: 147 -- 152 (2010), 2012
Malaria disease is a major global health and economic development threat. It results in approximately 2.7 million deaths annually. There is currently no vaccine that has been licensed for use against malaria. Studies in animal models, especially non-human primates can lead to the revelation of possible immunological mechanisms that can lead to ...
arxiv  

FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway

FEBS Open Bio, EarlyView.
We explored the role of FSH on the synovium and found that FSH was able to mediate the development of osteoarthritis by acting on the FSH receptor (FSHR) to promote the production and release of inflammatory factors through the activation of the NFκB signaling pathway. Previous studies have suggested that women with higher follicle‐stimulating hormone (
Yu Chen, Na Xu, Wen‐wen Zhang, Yan Wang, Tong Su, Yan‐man Zhou, Jin Xu   +6 more
wiley   +1 more source

An Investigation into Outlier Elimination and Calculation Methods in the Determination of Reference Intervals using Serum Immunoglobulin A as a Model Data Collection [PDF]

arXiv, 2019
Background: Reference intervals are essential to interpret diagnostic tests, but their determination has become controversial. Methods: In this paper parametric, non-parametric and robust reference intervals with Tukey and block elimination are calculated from a dataset of over 32,000 serum immunoglobulin A (IgA) measurements.
arxiv  

CD44v, S1PR1, HER3, MET and cancer‐associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb

FEBS Open Bio, EarlyView.
Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano, Kouki Okita, Shogo Okazaki, Soshi Yoshimoto, Sachiko Masuko, Hideki Yagi, Kazunori Kato, Yoshihisa Tomioka, Kenichi Imai, Yoichi Hamada, Kazue Masuko, Kayoko Shimada‐Takaura, Noriaki Nagai, Hideyuki Saya, Tomio Arai, Toshiyuki Ishiwata, Takashi Masuko   +16 more
wiley   +1 more source