Results 201 to 210 of about 70,538 (300)

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Economic impact of immunoglobulin replacement therapy in secondary immunodeficiency to hematological cancer: a single center observational study. [PDF]

Front Immunol
Guerola LDC, Sacristán AAG, Portolés A, Jasso M, Guerra-Galán T, de la Fuente-Munoz E, Palacios-Ortega M, Fernández-Arquero M, Cuesta-Mínguez C, Rodríguez-Sanz A, Peña-Cortijo A, Polo M, Morales MM, Anguita-Mandly E, Benítez Jiménez T, Benavente Cuesta C, Sánchez-Ramón S.   +16 more
europepmc   +1 more source

Efficacy of Plasmapheresis and Immunoglobulin Replacement Therapy (IVIG) on Patients with COVID-19. [PDF]

SN Compr Clin Med, 2020
Pourahmad R, Moazzami B, Rezaei N.
europepmc   +1 more source

Detection of Impaired IgG Antibody Formation Facilitates the Decision on Early Immunoglobulin Replacement in Hypogammaglobulinemic Patients [PDF]

, 2015
Hermann M. Wolf, Jiri Litzman, Martha M. Eibl, Vojtech Thon   +3 more
core   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Cost Utility of Lifelong Immunoglobulin Replacement Therapy vs Hematopoietic Stem Cell Transplant to Treat Agammaglobulinemia.

JAMA Pediatr, 2022
Sun D, Heimall JR, Greenhawt MJ, Bunin NJ, Shaker MS, Romberg N.   +5 more
europepmc   +1 more source

Machine Learning‐Driven Digital Twin of a Field‐Effect Transistor‐Based Hormone Biosensor for Real‐Time Estradiol Monitoring

Advanced Intelligent Systems, EarlyView.
A machine learning‐driven digital twin simulates an aptamer‐functionalized BioFET measuring 17β‐estradiol. Real‐time Isd signals are processed, features are extracted, and trained models estimate hormone concentration. In parallel, a one‐step‐ahead forward model learns biosensor dynamics and generates realistic synthetic signals, enabling in silico ...
Anastasiia Gorelova, Alexandra Parichenko, Shirong Huang, Santiago Melia, Gianaurelio Cuniberti   +4 more
wiley   +1 more source

Subcutaneous immunoglobulin replacement therapy in patients with immunodeficiencies - impact of drug packaging and administration method on patient reported outcomes. [PDF]

BMC Immunol
Mallick R, Solomon G, Bassett P, Zhang X, Patel P, Lepeshkina O.   +5 more
europepmc   +1 more source