Results 271 to 280 of about 326,951 (318)

IMMUNOGLOBULIN VARIABLE REGIONS AS IDIOTYPE VACCINES

Infectious Disease Clinics of North America, 1999
This article focuses on the use of immunoglobulin variable regions, including Id, anti-Id, anticlonotypes, and Id engineering as putative vaccines and vaccine strategies for infectious diseases; and specific discussion of Id systems involving antigenic determinants associated with potentially pathogenic organisms.
P S, Hefty, R C, Kennedy
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Immunoglobulin variable-region diversity in the zebrafish

Immunogenetics, 2000
As part of an investigation of the immune system in the developing zebrafish, Danio rerio, we cloned and characterized a genomic V(H) segment and a number of cDNAs encoding IgM heavy chains. The genomic V(H) has the characteristic features of V(H) in other vertebrates, including a leader segment interrupted by a short intron, and regulatory and ...
N, Danilova, V S, Hohman, E H, Kim, L A, Steiner   +3 more
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Genetics of the immunoglobulin variable region

Immunogenetics, 1974
On March 25 and 26, 1974, the Tumor Immunology Program of the National Cancer Institute sponsored a workshop on recent progress in the genetic analysis of antibody structural genes. The intent of the meeting was: 1. To define the genetics of markers currently used.
Martin Weigert, Michael Potter, David Sachs   +2 more
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Immunoglobulin variable region structure and B-Cell malignancies

International Journal of Hematology, 2001
The enormous diversity of immunoglobulin (Ig) variable (V) gene sequences encoding the antibody repertoire are formed by the somatic recombination of relatively few genetic elements. In B-lineage malignancies, Ig gene rearrangements have been widely used for determining clonality and cell origin.
H, Kiyoi, T, Naoe
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Phylogenetic Aspects of Immunoglobulin Variable Region Diversity

1974
There is now widespread agreement that the antigen-binding function of immunoglobulin molecules is mediated by the variable regions of their heavy and light polypeptide chains. Studies from a number of laboratories have shown that many general features of antibodies, such as the capacity to interact with a given antigen (e.g., dinitrophenyl ...
J M, Kehoe, J D, Capra
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Immunoglobulin Variable Region Genes

Pathology and Immunopathology Research, 1984
The picture that emerges of a V gene locus, albeit still sketchy, is one of a continuously evolving region, subject on occasion to quite dramatic flux due to the operation of gene conversion, transposing elements, recombination and unequal crossing over.
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Selection of Immunoglobulin Variable Regions in Autoimmunity to DNA

Immunological Reviews, 1992
Results from our analyses of variable region gene usage among spontaneous anti-DNA antibodies in autoimmune mice have indicated that both the early IgM and later-appearing IgG autoantibodies to DNA are generated by clonally selected B cells. The recurrent usage of particular variable region genes among all the anti-DNA hybridomas analyzed and reported ...
T N, Marion, D M, Tillman, N T, Jou, R J, Hill   +3 more
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Somatic mutation of immunoglobulin light-chain variable-region genes

Cell, 1981
A single germline immunoglobulin kappa-variable-region gene, VK167, is rearranged and expressed in two myelomas, MOPC167 and MOPC511. Only this single germline gene displays close homology to the expressed genes. Neither of the rearranged, functional genes, however, has a nucleotide sequence that is identical to the germline VK167 gene.
E, Selsing, U, Storb
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Immunoglobulin Variable Region Usage in Human Intestinal B Lymphocytes

Clinical Immunology and Immunopathology, 1994
The B cell repertoire was studied in intestinal mononuclear cells from normal individuals and patients with inflammatory bowel disease (IBD) by examining Ig heavy chain variable gene (VH) usage. Using reverse transcription of intestinal mucosal RNA followed by polymerase chain reaction with primers specific for each VH family and a housekeeping gene, a
R P, McCabe, W L, Carroll, M, Egan, S M, Cohn, M, Peters   +4 more
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Modeling the variable region of immunoglobulins

ImmunoMethods, 1992
The structures of over 30 Fab fragments have been solved using X-ray diffraction methods. The available coordinates are being used to model the variable region of other immunoglobulins for which only the sequence is known. Modeling the combining site of an immunoglobulin is a much more difficult problem than is usually perceived.
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