Results 261 to 270 of about 163,653 (347)

Analysis of immunoglobulin variable region genes of a human IgM anti‐myeloperoxidase antibody derived from a patient with vasculitis

, 1996
CM Longhurst, Michael R. Ehrenstein, Brian Leaker, Freda K. Stevenson, Myfanwy B. Spellerberg, CJ Chapman, D. LATCHMEN, David Isenberg, Geraldine Cambridge   +8 more
openalex   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (<i>Pteropus alecto</i>). [PDF]

Front Immunol
Hen JJ, Isaacs A, Liang B, Schountz T, Chappell K, Young PR, Modhiran N, Watterson D.   +7 more
europepmc   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Immunogenetic Architecture of Chronic Lymphocytic Leukemia at Early Stage: Insights from the O-CLL1 Cohort. [PDF]

Antibodies (Basel)
Bagnara D, Mazzarello AN, Colombo M, Nano E, Cardente N, Ferrero F, Bertola N, Cossu V, Ghiotto F, Ibatici A, Angelucci E, Neri A, Gentile M, Morabito F, Ferrarini M, Cutrona G, Fais F.   +16 more
europepmc   +1 more source

Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14

, 1982
O. Wesley McBride, James F. Battey, Gregory Hollis, David C. Swan, Ulrich Siebenlist, Philip Leder   +5 more
openalex   +2 more sources

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era. [PDF]

Eur J Immunol
Lindahl H, Shaw-Saliba K, Larman HB, Smith CIE, Bergman P.   +4 more
europepmc   +1 more source

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line.

, 1995
Nancy Green, J L Rabinowitz, Min Zhu, Barry Kobrin, Matthew D. Scharff   +4 more
openalex   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source