Results 271 to 280 of about 89,290 (305)

Immunoglobulin Variable Region Usage in Human Intestinal B Lymphocytes

Clinical Immunology and Immunopathology, 1994
The B cell repertoire was studied in intestinal mononuclear cells from normal individuals and patients with inflammatory bowel disease (IBD) by examining Ig heavy chain variable gene (VH) usage. Using reverse transcription of intestinal mucosal RNA followed by polymerase chain reaction with primers specific for each VH family and a housekeeping gene, a
R P, McCabe, W L, Carroll, M, Egan, S M, Cohn, M, Peters   +4 more
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Somatic mutation of immunoglobulin light-chain variable-region genes

Cell, 1981
A single germline immunoglobulin kappa-variable-region gene, VK167, is rearranged and expressed in two myelomas, MOPC167 and MOPC511. Only this single germline gene displays close homology to the expressed genes. Neither of the rearranged, functional genes, however, has a nucleotide sequence that is identical to the germline VK167 gene.
E, Selsing, U, Storb
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Effect of immunoglobulin variable region structure on C3b and C4b deposition

Molecular Immunology, 1996
Many of the biological activities of immunoglobulins, including interaction with the complement system, are attributed to the structure of the heavy chain constant domains. However, previous studies indicated that immune complexes formed with independently derived isotype-matched pairs of monoclonal antibodies vary with respect to their capacity to ...
K D, White, M B, Frank, S, Foundling, F J, Waxman   +3 more
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Functional and Structural Implications of Variable Region Immunoglobulin Dynamic States

Immunological Investigations, 1988
The consequence of multiple conformational states in the immunoglobulin variable region are considered. Bound ligand is viewed as a stabilizer of one conformer from a series of non-liganded conformers. Kinetic, equilibrium, thermodynamic and crystal formation information are used as supporting evidence for a unique conformer which is the crystallizable
E W, Voss, M A, Dombrink-Kurtzman, S D, Miklasz   +2 more
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Expression of Immunoglobulin Variable Region Antigens on Mouse B Lymphocytes

The Journal of Immunology, 1979
Abstract Rabbit antibodies prepared against two purified 7S BALB/c myeloma proteins, A2 (γ1, κ) and MOPC 195 (γ2b, κ), and solid-phase absorbed so as to contain only anti-heavy (H) chain specificities bound to 32 to 35% of C57BL/6 lymph node lymphocytes (about 80% of the B lymphocytes).
Stanislawski, M, Mitard, M
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Influence of Clonal Selection on the Expression of Immunoglobulin Variable Region Genes

Science, 1984
The humoral immune response of the mouse to certain antigens is characterized by the dominant expression of a single or limited number of related, immunoglobulin variable region (V) structures by antibody-secreting lymphocytes. Such dominance could be due to preferred expression of these V regions in the B cell population prior to the ...
T, Manser, S Y, Huang, M L, Gefter
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An idiotypic determinant formed by both immunoglobulin constant and variable regions

Nature, 1983
Immunoglobulin idiotypes are serologically defined determinants associated with the variable (V) region of antibody molecules (reviewed in refs 1-4). One of the best defined idiotype systems is that borne by the phosphorylcholine (PC)-binding IgA proteins TEPC15 (T15) and HOPC8 (H8).
G, Morahan, C, Berek, J F, Miller
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Genetic Control of Variable and Constant Regions of Immunoglobulin Heavy Chains

Nature New Biology, 1971
IMMUNOGLOBULIN polypeptide chains consist of two well defined regions designated the “variable region” and the “constant region”. Whereas great diversity exists in amino-acid sequences of variable regions, the constant regions of a given subclass of heavy chains (CH)* are essentially invariant in sequence1, 2.
R G, Mage, G O, Young-Cooper, C, Alexander   +2 more
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Heating of immunoglobulins for immunoblot analysis destroys variable region antigenicity

Journal of Immunological Methods, 1986
The antigenicity of rabbit immunoglobulin heavy chain variable region allotypes was examined by immunoblotting after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The standard method of sample preparation resulted in a total loss of immunoreactivity with anti-allotype antibody due to heating of the samples prior to their electrophoresis ...
V H, Van Cleave, D W, Metzger
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Immunoglobulin variable region sequences of humanmonoclonal anti-DNA, antibodies

Seminars in Arthritis and Rheumatism, 1998
Anti-DNA antibodies are believed to be important in the pathogenesis of systemic lupus erythematosus (SLE). Antibodies that bind specifically and with high affinity to dsDNA are most closely involved in tissue damage. Analysis of the sequences of the variable regions of human monoclonal anti-DNA antibodies is useful in defining the structural features ...
A, Rahman, D S, Latchman, D A, Isenberg
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