Results 271 to 280 of about 163,653 (347)

Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study. [PDF]

Front Immunol
Lee JH, Lin YT, Wang LC, Yu HH, Hu YC, Yang YH, Chiang BL.   +6 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Unveiling key pathways and potential biomarkers for high-altitude hypertension: a pilot multi-omics study. [PDF]

Sci Rep
Huang J, Danzeng Z, Gesang L, Ci B, Suona Y, Zhang R, Ciren Z, Yuan C, Baima Y, Wang Y, Pubu Z, Zhuoma P, Lamu Z, Suolang W.   +13 more
europepmc   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Pathogen Detection and Analysis of Non-Infectious Factors in Calf Diarrhea at a Large-Scale Dairy Farm in Wuwei City. [PDF]

Vet Sci
Li Y, Wang L, Xu G, Zhang J, Hanyurwumutima E, Zhao Y, Li J, Feng X, Zhou Y, Wang T, Chen X, Wei L, Zhang K, Li J.   +13 more
europepmc   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Evaluation of vaccine-induced antibody responses against SARS-CoV-2 in multiple myeloma patients from the northeastern region of Mexico. [PDF]

Hematol Transfus Cell Ther
Salazar-Riojas R, Alvarado-Navarro DM, Ruiz-de la Cruz ML, Castro-Fuentes LN, Vazquez-Hernandez KE, Gomez-Almaguer D, Rosas-Taraco AG.   +6 more
europepmc   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Mass spectrometry-based analysis of rheumatoid factor. [PDF]

Front Immunol
De Leeuw J, Michiels B, Derua R, Dehaemers T, Dillaerts D, Cockx M, Frans G, Carpentier SC, Verschueren P, Bossuyt X.   +9 more
europepmc   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source