Results 91 to 100 of about 655,587 (248)

A universal immunohistochemistry analyzer for generalizing AI-driven assessment of immunohistochemistry across immunostains and cancer types

npj Precision Oncology
Immunohistochemistry (IHC) is the common companion diagnostics in targeted therapies. However, quantifying protein expressions in IHC images present a significant challenge, due to variability in manual scoring and inherent subjective interpretation ...
Biagio Brattoli, Mohammad Mostafavi, Taebum Lee, Wonkyung Jung, Jeongun Ryu, Seonwook Park, Jongchan Park, Sergio Pereira, Seunghwan Shin, Sangjoon Choi, Hyojin Kim, Donggeun Yoo, Siraj M. Ali, Kyunghyun Paeng, Chan-Young Ock, Soo Ick Cho, Seokhwi Kim   +16 more
doaj   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry

, 2019
Jenny Lazarus, Yagiz Matthew Akiska, Mirna Perusina Lanfranca, Lawrence Delrosario, Lei Sun, Daniel D. Long, Jiaqi Shi, Howard C. Crawford, Marina Pasca di Magliano, Weiping Zou, Timothy L. Frankel   +10 more
openalex   +2 more sources

Integrating and validating automated digital imaging analysis of estrogen receptor immunohistochemistry in a fully digital workflow for clinical use

, 2022
Saba Shafi, David A. Kellough, Giovanni Lujan, Swati Satturwar, Anil V. Parwani, Zaibo Li   +5 more
openalex   +1 more source

A Novel Microfluidic System for 3D Epidermis and Full‐Thickness Skin Growth for Nanoparticle Safety Assessment

Advanced Healthcare Materials, EarlyView.
This work presents a novel, dynamically perfused, configurable microfluidic system for epidermis‐only (E and full‐thickness skin (FT SoC) growth, emulating human skin structure and barrier function. Upon TiO2 nanoparticle exposure, the system reveals compromised barrier integrity, reduced metabolic activity, increased permeability, and chemokine‐driven
Samantha Costa, Ana B. Carneiro, Filipa Lebre, João Meneses, Alar Ainla, Cacilda Moura, Ernesto Alfaro‐Moreno, Ana R. Ribeiro   +7 more
wiley   +1 more source

Computational Immunohistochemistry: Recipes for Standardization of Immunostaining

, 2017
Nuri Murat Arar, Pushpak Pati, Aditya Kashyap, Anna Fomitcheva Khartchenko, Orçun Göksel, Govind V. Kaigala, Maria Gabrani   +6 more
openalex   +2 more sources

Progesterone Receptor Positive by Immunohistochemistry 51-60 Percent [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

The Value of Immunohistochemistry in the Fine-Needle Aspiration Diagnosis of Salivary Gland Lesions [PDF]

, 2018
Elmira Vaziri Fard, Manju Ambelil, Suhair Al Salihi, Christine Liang, Hui Zhu, Jing Liu, Peisha Yan, Jaiyeola Thomas-Ogunniyi, Songlin Zhang   +8 more
openalex   +1 more source