Results 241 to 250 of about 963,734 (335)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Dynamic changes in sumoylation related proteins SUMO1, SENP1, and UBC9 during the peri implantation period in mice. [PDF]

Sci Rep
Golal E, Balci CN, Acar N.
europepmc   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Development and clinical validation of deep learning-based immunohistochemistry prediction models for subtyping and staging of gastrointestinal cancers. [PDF]

BMC Gastroenterol
Wang J, Zhang S, Li J, Deng M, Zeng Z, Dong Z, Chen F, Liu W, Wu L, Yu H.   +9 more
europepmc   +1 more source

Immunohistochemistry of vascular changes in leuprolide acetate–treated leiomyomas

, 1997
Augusto F. Mesia, Deborah Gahr, Michael Wild, Khush Mittal, Rita I. Demopoulos   +4 more
openalex   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Computer-aided techniques for Chromogenic Immunohistochemistry: Status and Directions [PDF]

, 2012
Al-Kofahi, Al-Kofahi, Baggett, Beck, Bogen, Borad, Boykov, Brennan, Brey, Brgmann, Canny, Cheng, Choudhury, Cooper, Cregger, Cross, Cualing, De Solorzano, Demir, Di Cataldo, Di Cataldo, Diaz, Dickinson, DiVito, Dobson, Elisa Ficarra, Elmoataz, Enrico Macii, Ficarra, Ficarra, Ficarra, Flowers, Fuchs, Garrido, Gilbert, Goldstein, Gudla, Gurcan, Gustavson, Hai-Shan Wu, Hama, Han, Hanna, He, Huang, Ingle, Jacob, Kim, Kong, Kurosumi, Lacroix-Triki, Landini, Lehr, Leong, Loos, Luck, Madabhushi, Makretsov, Malpica, Marttila, Masmoudi, Mccullough, Moffitt, Moon, Mueller, Mukherjee, Otsu, Petushi, Pietrini, Queschi, Ramos-Vara, Riera, Roerdink, Rojo, Ruifrok, Santa Di Cataldo, Scholzen, Sharpe, Shi, Shi, Slodkowska, Sompuram, Sun, Taneja, Taylor, Taylor, Theodosiou, Thiran, Tuominen, Umemura, Vonesch, Wang, Ward, Wolff, Woolley, Yang, Zacharaki, Zanella   +97 more
core   +1 more source

Exploring the role of monocarboxylate transporter 4 in diverse KRAS mutation subtypes of colorectal Cancer. [PDF]

Sci Rep
Gong Q, Huang J, Li Q, Zhang S, Xiao M, Li M, Yang Y, Tang Y, Wang Y.   +8 more
europepmc   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

Diagnostic Utility of Podoplanin Immunohistochemistry Combined with the NanoSuit-Correlative Light and Electron Microscopy Method for Thoracic Malignant Tumors. [PDF]

Diagnostics (Basel)
Katsuragi SY, Sakano Y, Ohta I, Kato H, Ishikawa R, Watanabe H, Miyazaki R, Yoshimura K, Yamada H, Sakai Y, Inoue Y, Takanashi Y, Sekihara K, Funai K, Otsuki Y, Kawasaki H, Shinmura K.   +16 more
europepmc   +1 more source