Results 241 to 250 of about 1,228,272 (336)

Merlin immunoreactivity fails to predict neurofibromatosis type 2 mutations in human meningiomas. [PDF]

J Neuropathol Exp Neurol
Tollefsen SE, Meta R, Solheim O, Mjønes P, Vestrheim I, Sjursen W, Torp SH.   +6 more
europepmc   +1 more source

Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury

Advanced Science, EarlyView.
This study investigates the mechanism of succinate dehydrogenase (SDH)‐mediated succinate oxidation in microglia extracellular traps (MiETs) formation and neuronal injury after cerebra I/R injury. Dimethyl malonate (DMM), a competitive SDH inhibitor, could reduce MiETosis by inhibiting succinate oxidation and mtROS production during reperfusion ...
Lili Zhao, Tao Li, Meijuan Dang, Ye Li, Jialiang Lu, Ziwei Lu, Zhiyang Chen, Qiao Huang, Yujie Chen, Yang Yang, Yuxuan Feng, Xiaoya Wang, Yating Jian, Heying Wang, Yingying Guo, Lei Zhang, Yu Jiang, Songhua Fan, Shengxi Wu, Hong Fan, Fang Kuang, Guilian Zhang   +21 more
wiley   +1 more source

Painful Gluteal Lesion.

Indian J Dermatol
Akhila A, Murthy AB, Kaliaperumal K, Amirdambigai IS.   +3 more
europepmc   +1 more source

Epithelioid glioblastoma mimicking metastatic brain tumor: A case report and literature review. [PDF]

Radiol Case Rep
Watanabe C, Sekine T, Nakamura K, Muroi A, Ishikawa E, Komatsu Y.   +5 more
europepmc   +1 more source

Engineered RGD‐Treg‐Exos Targeted Delivery of miR‐218‐5p to Activate Mitophagy and Attenuate Podocyte Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
Tregs‐Exos deliver miR‐218‐5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. RGD‐Treg‐Exos, engineered to express RGD peptides on the membrane surface, bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR‐218‐5p, which increases mitophagy and reduces apoptosis in ...
Zhaochen Guo, Shaohui Gao, Ziyue Wang, Zige Chen, Jinglei Chen, Aiping Duan, Feng Xu, Qinger Wang, Weisong Qin, Caihong Zeng, Zhihong Liu, Hao Bao   +11 more
wiley   +1 more source

Learning to detect lymphocytes in immunohistochemistry with deep learning

Medical Image Anal., 2019
Zaneta Swiderska-Chadaj, H. Pinckaers, Mart van Rijthoven, M. Balkenhol, Margarita Melnikova, Oscar G. F. Geessink, Quirine F. Manson, M. Sherman, A. Polónia, J. Parry, M. Abubakar, G. Litjens, J. Laak, F. Ciompi   +13 more
semanticscholar   +1 more source

An Elderly Man with Epitheloid Angiosarcoma Presenting as Multiple Scalp Swellings. [PDF]

Indian Dermatol Online J
Shetty GV, Girish PN, Sandhya I.
europepmc   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang, Xueying Wang, Shanhong Lu, Yan Gao, Gangcai Zhu, Guo Li, Zongnan Yu, Junwei Hou, Helei Yan, Wenhui Yuan, Xin Zhang, Mien‐Chie Hung, Zhifeng Liu, Yong Liu   +13 more
wiley   +1 more source

Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can Brown do for you?

Human Pathology, 2019
A. Bellizzi
semanticscholar   +1 more source