Results 71 to 80 of about 1,228,272 (336)

Modulation of the host Th1 immune response in pigeon protozoal encephalitis caused by Sarcocystis calchasi [PDF]

, 2013
Pigeon protozoal encephalitis (PPE) is an emerging central-nervous disease of domestic pigeons (Columba livia f. domestica) reported in Germany and the United States.
Gruber, Achim D., Kaspers, Bernd, Klopfleisch, Robert, Lierz, Michael, Meyer, Anne, Olias, Philipp   +5 more
core   +3 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Reproducing the Molecular Subclassification of Peripheral T-cell Lymphoma-NOS by Immunohistochemistry.

Blood, 2019
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature T-cell malignancies with approximately one-third of cases designated as PTCL-not otherwise specified (PTCL-NOS).
Catalina Amador, T. Greiner, Tayla B. Heavican, Lynette M. Smith, Karen Galvis, Waseem G Lone, Alyssa Bouska, F. d'Amore, Martin Bjerregård Pedersen, S. Pileri, C. Agostinelli, A. Feldman, A. Rosenwald, G. Ott, A. Mottok, K. Savage, L. de Leval, P. Gaulard, S. Lim, C. Ong, S. Ondrejka, J. Song, E. Campo, E. Jaffe, L. Staudt, L. Rimsza, J. Vose, D. Weisenburger, W. Chan, J. Iqbal   +29 more
semanticscholar   +1 more source

The Intratumoral Heterogeneity Reflects the Intertumoral Subtypes of Glioblastoma Multiforme: A Regional Immunohistochemistry Analysis

Frontiers in Oncology, 2020
Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults. Despite extensive therapy the prognosis for GBM patients remains poor and the extraordinary therapy resistance has been attributed to intertumoral ...
Natalie Bergmann, C. Delbridge, J. Gempt, A. Feuchtinger, A. Walch, Lucas Schirmer, W. Bunk, T. Aschenbrenner, F. Liesche-Starnecker, J. Schlegel   +9 more
semanticscholar   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer [PDF]

, 2012
PMCID: PMC3446380This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
A Borg, AC Wolff, Adrian Harris, C Wright, DA Budwit-Novotny, DJ Slamon, DJ Slamon, E Tagliabue, EA Musgrove, EHR Perez, G Arpino, G Konecny, GD Lewis Phillips, Georges Sumo, IL Andrulis, Isabel Pinhel, Ivana Sestak, J Cuzick, J Vandesompele, JA Sparano, Jack Cuzick, Janine Salter, JC Brase, JM Harvey, Judith M Bliss, M Dowsett, M Dowsett, M Harigopal, Margaret Hills, ME Hammond, MF Press, Mitch Dowsett, MJ Ellis, MJ Ellis, MJ Piccart-Gebhart, N Quenel, P Royston, Peter Barrett-Lee, RL Camp, Roger A'Hern, S Drury, S Johnston, S Paik, SJ Houston, SS Badve, Suzanne Drury, The Adjuvant Breast Cancer Trials Collaborative Group, V Guarneri, VS Perez   +48 more
core   +5 more sources

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry

Journal of Clinical Pathology, 2016
Increased expression levels of KCNJ3 have been correlated with lymph node metastases and poor prognosis in patients with breast cancer, suggesting a prognostic role of KCNJ3.
Y. Ju, Ludmil B. Alexandrov, M. Gerstung, I. Martincorena, S. Nik-Zainal, Manasa Ramakrishna, Helen R Davies, E. Papaemmanuil, G. Gundem, A. Shlien, N. Bolli, S. Behjati, P. Tarpey, J. Nangalia, C. Massie, Adam P. Butler, J. Teague, G. Vassiliou, A. Green, Mingyuan Du, Ashwin Unnikrishnan, J. Pimanda, B. Teh, N. Munshi, M. Greaves, P. Vyas, A. E. Naggar, T. Santarius, V. P. Collins, Richard Grundy, Jack A. Taylor, D. Hayes, D. Malkin, Christopher S. Foster, A. Warren, H. Whitaker, D. Brewer, R. Eeles, Colin S. Cooper, D. E. Neal, T. Visakorpi, W. Isaacs, G. Bova, A. Flanagan, P. Futreal, A. Lynch, P. Chinnery, Ultan McDermott, Michael R. Stratton, Peter J. Campbell   +49 more
semanticscholar   +1 more source

Immunohistochemistry of the Skin [PDF]

Laboratory Medicine, 2003
have presented a host of fungal, viral, and bacterial infections of the skin. In the last decade, immunohisto- chemistry has played an increasingly important role for routine diagnosis, prognosis, and research. The complexity of all skin disorders makes it imperative to understand IHC and the different dis- ciplines that are required by today's der ...
openaire   +2 more sources

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice [PDF]

, 2011
Biochemical studies have suggested conflicting roles for the E3 ubiquitin ligase constitutive photomorphogenesis protein 1 (Cop 1; also known as Rfwd2) in tumorigenesis, providing evidence for both the oncoprotein c-Jun and the tumor suppressor p53 as ...
Aleksandra Zwolinska, Angel, Baert, Bannister, Chang, Chen, Danovi, de Launoit, Dentin, Derijard, Dieter Defever, Domenico Migliorini, Dornan, Edwards, Eferl, Enrico Radaelli, Fuchs, Geertrui Denecker, Horn, Jean-Christophe Marine, Karin, Kato, Kominami, Krummel, Kyriakis, Lopez-Bergami, Mariani, Marine, Mendrysa, Morse HC, Nakayama, Ouyang, Qi, Rajesh Vyas, Ramaswamy, Rincon, Rossant, Schreiber, Sven Bogaerts, Tino Hochepied, Vanessa Depaepe, Wang, William C. Skarnes, Zhong   +43 more
core   +2 more sources