Results 101 to 110 of about 2,266 (210)

Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY [PDF]

Biomolecules, 2014
IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics.
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Immunoinformatic design of a multivalent vaccine against Brucella abortus and its evaluation in a murine model using a DNA prime-protein boost strategy

Frontiers in Immunology
IntroductionThe development of effective vaccines against Brucella abortus is critical due to its significant impact on human and animal health. The objective of this study was to design and evaluate in silico and in vivo a multivalent vaccine based on ...
Raúl E. Molina, Alberto Osorio, Manuel Flores-Concha, Leonardo A. Gómez, Ilse Alvarado, Italo Ferrari, Angel Oñate   +6 more
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Multi-epitope peptide vaccines targeting dengue virus serotype 2 created via immunoinformatic analysis

The Middle East has witnessed a greater spread of infectious Dengue viruses, with serotype 2 (DENV-2) being the most prevalent form. Through this work, multi-epitope peptide vaccines against DENV-2 that target E and nonstructural (NS1) proteins were ...
Khaled M. Aboshanab, Radwa N. Morgan, Mohammad Y. Alshahrani, Nasser S. M. Ismail   +3 more
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In Silico Targeting and Immunological Profiling of PpiA in Mycobacterium tuberculosis: A Computational Approach

Pathogens
Tuberculosis (TB) remains a leading cause of mortality, with drug resistance highlighting the need for new vaccine targets. Peptidyl-prolyl isomerase A (PpiA), a conserved Mycobacterium tuberculosis (Mtb) protein, plays a role in bacterial stress ...
Mohammad J. Nasiri, Lily Rogowski, Vishwanath Venketaraman   +2 more
doaj   +1 more source

Immunoinformatics-guided design of a multiepitope peptide vaccine targeting the receptor-binding domain of SARS-CoV-2 spike glycoprotein: insights from Indonesian samples

Journal of Integrative Bioinformatics
The emergence of new variants of SARS-CoV-2, including Alpha, Beta, Gamma, Delta, Omicron variants, and XBB sub-variants, contributes to the number of coronavirus cases worldwide.
Faizal Irvan, Chandra Darrian, Tarwadi, Pambudi Sabar, Nurhasanah Astutiati, Priambodo Rizky, Yusuf Muhammad   +6 more
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IMGT-Choreography for immunogenetics and immunoinformatics.

In silico biology, 2004
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), was created in 1989 at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system ...
Lefranc, Marie-Paule, Clément, Olivier, Kaas, Quentin, Duprat, Elodie, Chastellan, Patrick, Coelho, Isabelle, Combres, Kora, Ginestoux, Chantal, Giudicelli, Véronique, Chaume, Denys, Lefranc, Gérard   +10 more
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A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine design to in vitro evaluation of immunogenicity

Frontiers in Microbiology
BackgroundTreponema pallidum, the causative spirochete of syphilis, is primarily transmitted through sexual contact and has emerged as a significant global health concern.
Jing Jiang, Jing Jiang, Linglan Xu, Linglan Xu, Xuefeng Wang, Ming Wang, Youde Cao, Ranhui Li, Kang Zheng, Xian Wu   +9 more
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Proteome-wide screening for designing a multi-epitope vaccine against emerging pathogen Elizabethkingia anophelis using immunoinformatic approaches

, 2019
Elizabethkingia anophelis is an emerging human pathogen causing neonatal meningitis, catheter-associated infections and nosocomial outbreaks with high mortality rates. Besides, they are resistant to most antibiotics used in empirical therapy.
Md. Shakil Ahmed Khan (7891823), Shafi Mahmud (7493780), Md. Moinuddin Sheam (7891826), S. M. Raihan Rahman (7845473), Utpal Kumar Adhikari (7845482), Zulkar Nain (7845458), Faruq Abdulla (8061062), M. Mizanur Rahman (7845464), Mohammad Minnatul Karim (4013828), Sifat Bin Sayed (7845470), Zahurul Haque (7845479)   +10 more
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Designing and Cloning of the Gene Vaccine Carrying the Viral Haemorrhagic Septicaemia Multi‐Epitope Gene in the pNZ8121 Secretion Vector

Veterinary Medicine and Science
The viral haemorrhagic septicaemia virus (VHSV) is considered a very significant disease affecting fish. The objective of this project is to develop a multi‐epitope vaccine targeting viral hemorrhagic fever using the reverse vaccinology approach. Epitope
Ramin Shukripour, Abbas Doosti, Mohsen Forouzanfar, Mojtaba Jafarinia   +3 more
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Immunoinformatics: Implications on Reverse Vaccinology

Immunochemistry & Immunopathology, 2017
One area in which immunological studies have had most immediate and successful application is in the field of vaccination. Vaccines represent one of the greatest interventions in modern medicine [1]. Ever since Edward Jenner’s first use of a vaccine against smallpox in 1796, the use of vaccines has become indispensable to the eradication of disease [2].
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