Results 91 to 100 of about 2,266 (210)

Genome‐Guided Discovery of Vaccine Targets for a Multi‐Epitope Construct Against Multidrug‐Resistant Enterobacter cloacae

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Multidrug‐resistance (MDR) Enterobacter cloacae was targeted using a genome wide immunoinformatics approach. Conserved and surface exposed outer membrane protien A (OmpA) was identified as the prime vaccine target following proteome screening, antigenicity, allergenicity, and homology analysis.
Maha A. Aljumaa, Fakhria A. Al‐Joufi, Ghulam Nabi, Mengue Ngadena Yolande Sandrine   +3 more
wiley   +1 more source

Immunoinformatic analysis of conserved immunodominant epitopes derived from Newcastle disease virus strains prevalent in West Africa

The purpose of this study was to design an epitope-based vaccine targeting the currently circulating genotypes of Newcastle disease virus (NDV) in West Africa using immunoinformatic approaches.
M.B. Bello, N. Lawal
core   +1 more source

Computational Design of an mRNA Vaccine Targeting LRP6 for Triple‐Negative Breast Cancer Therapy

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Triple‐negative breast cancer (TNBC) presents a poorer prognosis than other breast cancer subtypes, attributed to its aggressive nature and the lack of specific therapeutic interventions. TNBC has high recurrence rates and limited survival despite current therapies, emphasizing the critical need for improved treatment options.
Pooriya Teimoori, Mohammadreza Heidari
wiley   +1 more source

Immunoinformatic discovery of potential cross-reactive T cell epitopes in the measles genome

, 2011
T cells are key mediators of inflammatory processes that can be activated by pathogens and vaccines. Some vaccine antigens may encode T cell epitopes that can cross-react with either human or human microbiome epitopes, causing deviation of the T cell ...
Martin, William, De Groot, Anne S., Eric Gustafson, Ardito, Matthew, Alan Rothman, William Martin, Rothman, Alan, Anne S. De Groot, Moise, Lenny, Lenny Moise, Gustafson, Eric, Matthew Ardito   +11 more
core   +1 more source

Deep Learning‐Enabled Engineering of a Hyper‐Stable and Soluble MPB70‐83 Antigen for Sensitive Bovine Tuberculosis Surveillance

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Schematic representation of the research workflow for the efficient diagnosis of bovine tuberculosis employing peptide fusion proteins. ABSTRACT Bovine tuberculosis (bTB) diagnostics are frequently hindered by the structural instability and insolubility of recombinant multi‐epitope proteins in prokaryotic expression systems.
Wen‐Hao Wang, Jia‐Zhen Ge, Ying‐Ying Xie, Guo‐Dong Song, Yijian Liu, Yin‐juan Song, Ren‐ge Li, Rui‐Shuang Li, Zi‐qing Wang, Xin‐Miao Liu, Shuang‐Shuang Guo, Jie Li, Shengli Chen, Na Li, Fuying Zheng, Yuefeng Chu   +15 more
wiley   +1 more source

Investigation of immunogenic properties of Hemolin from silkworm, Bombyx mori as carrier protein: an immunoinformatic approach

, 2018
Infectious diseases are the major cause of high mortality among infants and geriatric patients. Vaccines are the only weapon in our arsenal to defend us ourselves against innumerable infectious diseases.
Muthukalingan Krishnan, Veeranarayanan Surya Aathmanathan, Nattarsingam Jothi, Vijay Kumar Prajapati   +3 more
core   +1 more source

A comprehensive immunoinformatic analysis of chitin deacetylase’s and MP88 for designing multi-epitope vaccines against Cryptococcus neoformans

, 2023
Cryptococcus neoformans causes life-threatening pneumonia and meningitis and is regarded as one of the leading killers of immunocompromised individuals. There is currently no vaccine against this pathogen.
Md Abu Sayem Khan (17005269), Sabita Rezwana Rahman (11435439), Md Ibrahim Miah (17005272)   +2 more
core   +1 more source

Proteome-wide screening for designing a multi-epitope vaccine against emerging pathogen Elizabethkingia anophelis using immunoinformatic approaches

, 2020
Elizabethkingia anophelis is an emerging human pathogen causing neonatal meningitis, catheter-associated infections and nosocomial outbreaks with high mortality rates. Besides, they are resistant to most antibiotics used in empirical therapy.
Mahmud, Shafi, S. M. Raihan Rahman, Zahurul Haque, Md. Shakil Ahmed Khan, Sifat Bin Sayed, Khan, Md. Shakil, Haque, Zahurul, Mohammad Minnatul Karim, Karim, Mohammad M., Faruq Abdulla, Zulkar Nain, M. Mizanur Rahman, Sheam, Md. Moinuddin, Utpal Kumar Adhikari, Rahman, Sadaqur M., Shafi Mahmud, Adhikari, Utpal Kumar (S34370), Rahman, Md. M., Abdulla, Faruq, Nain, Zulkar, Md. Moinuddin Sheam, Sayed, Sifat B.   +21 more
core   +1 more source

Targeting Polyprotein to Design Potential Multiepitope Vaccine against Omsk Hemorrhagic Fever Virus (OHFV) by Evaluating Allergenicity, Antigenicity, and Toxicity Using Immunoinformatic Approaches

Biology
Omsk Hemorrhagic Fever Virus (OHFV) is an RNA virus with a single-stranded, positive-sense genome. It is classified under the Flaviviridae family. The genome of this virus is 98% similar to the Alkhurma hemorrhagic fever virus (AHFV), which belongs to ...
Abdullah M. Alnuqaydan, Alaa Abdulaziz Eisa   +1 more
doaj   +1 more source

Immunoinformatics: Current trends and future directions

Drug Discovery Today, 2009
Immunoinformatics has recently emerged as a critical field for accelerating immunology research. Although still an evolving process, computational models now play instrumental roles, not only in directing the selection of key experiments, but also in the formulation of new testable hypotheses through detailed analysis of complex immunologic data that ...
Tong, Joo Chuan, Ren, Ee Chee
openaire   +2 more sources