Results 71 to 80 of about 2,266 (210)

Multi-Epitope-Based Vaccine Candidate for Monkeypox: An In Silico Approach

Vaccines, 2022
Currently, there are limited treatment options available for the monkeypox disease. We used a computational strategy to design a specific antigenic vaccine against pathogens.
Sayed Aliul Hasan Abdi, Amena Ali, Shabihul Fatma Sayed, Abutahir, Abuzer Ali, Prawez Alam   +5 more
doaj   +1 more source

Designing and Evaluation of a Multiepitope Vaccine against Avian Newcastle Disease Virus, Influenza Virus and Infectious Bronchitis Virus [PDF]

Pharmaceutical Sciences
Background: Poultry industries play an important role in the human food supply. Newcastle disease virus (NDV), Infectious bronchitis virus (IBV), and Avian influenza virus (AIV) can cause epizootic outbreaks in poultry industries and lead to extensive ...
Morteza Ghandadi
doaj   +1 more source

Homology Modeling of Sesame Allergenic Protein and Prediction of B-Cell Linear Antigenic Epitopes Using Immunoinformatic Tools. [PDF]

Foods
Sesame (Sesamum indicum L.) has emerged as a significant food allergen and is now classified among the “Big Eight” allergens due to its increasing prevalence and potential to cause severe allergic reactions, including anaphylaxis.
Ma X, Wang F, Yu N, Zhang J, Wang X, Xie M, Ge Y, Chen Y.   +7 more
europepmc   +2 more sources

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source

Design and Immunoinformatic Assessment of Candidate Multivariant mRNA Vaccine Construct against Immune Escape Variants of SARS-CoV-2

, 2022
To effectively counter the evolving threat of SARS-CoV-2 variants, modifications and/or redesigning of mRNA vaccine construct are essentially required. Herein, the design and immunoinformatic assessment of a candidate novel mRNA vaccine construct, DOW-21,
Qureshi, Iffat Waqar, Ayesha Aslam, Fozia Raza, Mushtaq Hussain, Muneeba Ahsan Sayeed, Humera Waheed, Sanya Shabbir, Sayeed, Muneeba Ahsan, Anusha Amanullah, Jabeen, Nusrat, Iffat Waqar Qureshi, Quraishy, Saeed, Waheed, Humera, Hussain, Mushtaq, Aslam, Ayesha, Amanullah, Anusha, Shabana Arzoo, Nusrat Jabeen, Saeed Quraishy, Raza, Fozia, Arzoo, Shabana, Shabbir, Sanya   +21 more
core   +1 more source

Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatic approach

Инфекция и иммунитет
Background.An outbreak of SARS-CoV-2 in 2019 has brought a great challenge to public health and rapid identification of immune epitopes for designing an effective vaccine for different variants of SARS-CoV-2 is necessary at the time of the pandemic ...
V. Alamdari-Palang, Z. Dehghan, M. Kian, S. Zonar, J. Fallahi, M. Sisakht, S. Khajeh, V. Razban   +7 more
doaj   +1 more source

Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, OvMANE1: preclinical evaluation in a mice model

Clinical &Translational Immunology, Volume 15, Issue 7, 2026.
OvMANE1 formulated with Freund's adjuvant was safe and elicited strong humoral and cellular immune responses, including significant IgG and leukocyte activation. These findings highlight OvMANE1 as a promising multi‐epitope vaccine candidate for advancing onchocerciasis prevention.
Derrick Neba Nebangwa, Mary Teke Efeti, Sonia M. E. Momnougui, Cabirou Mounchili Shintouo, Robert Adamu Shey, Rene Bilingwe Ayiseh, Fidele Ntie‐Kang, Stephen Mbigha Ghogomu   +7 more
wiley   +1 more source

Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India

Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.
Chandipura virus (CHPV), a neurotropic arbovirus transmitted primarily by sandflies, has emerged as a significant public health concern in India following recurrent outbreaks with high pediatric fatality rates. This review highlights the virus's virology, transmission dynamics, clinical features, and the urgent need for improved diagnostics ...
Abrar Ahmad Zargar, Reena Gupta, P. Krishnamoorthy   +2 more
wiley   +1 more source

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1403-1426, July 2026.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms

, 2023
Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (a-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Tan, Kae Yi, Chan, Yi Wei, Tan, Choo Hock, Heh, Choon Han   +3 more
core