Results 61 to 70 of about 2,266 (210)

Immunogenicity of Trypanosoma cruzi Multi-Epitope Recombinant Protein as an Antigen Candidate for Chagas Disease Vaccine in Humans

Pathogens
Chagas disease, caused by the protozoan Trypanosoma cruzi (T. cruzi), is the most significant neglected tropical disease affecting individuals in the Americas.
Christian F. Teh-Poot, Andrea Alfaro-Chacón, Landy M. Pech-Pisté, Miguel E. Rosado-Vallado, Oluwatoyin Ajibola Asojo, Liliana E. Villanueva-Lizama, Eric Dumonteil, Julio Vladimir Cruz-Chan   +7 more
doaj   +1 more source

Rpf‐Toxo: A Preliminary Computationally Designed Dense Granule Antigen‐Based Multi‐Epitope Vaccine Against Toxoplasma gondii

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This graphical abstract summarizes the in silico design of the multi‐epitope vaccine candidate Rpf‐Toxo (Seq4) against Toxoplasma gondii. The workflow includes antigen selection, epitope mapping, vaccine construction, structural and immunological evaluation, toll‐like receptor‐4 docking, immune simulation, safety assessment, codon optimisation and ...
Mohamad Hosein Safari, Seyyed Amir Hosseini, Shadan Ghiabi, Shamim Ghiabi, Davood Siamian, Hamidreza Majidiani, Hamid Irannejad, Ali Asghari   +7 more
wiley   +1 more source

DataSheet_4_“Immunoinformatic Identification of T-Cell and B-Cell Epitopes From Giardia lamblia Immunogenic Proteins as Candidates to Develop Peptide-Based Vaccines Against Giardiasis”.pdf

, 2021
Giardiasis is one of the most common gastrointestinal infections worldwide, mainly in developing countries. The etiological agent is the Giardia lamblia parasite.
Thania Garzon (11611648), Efrain Alday (11611657), Carlos Velazquez (11611660), Ramón Enrique Robles-Zepeda (11175906), David Ortega-Tirado (11611651), Gloria Lopez-Romero (11611654), Adriana Garibay-Escobar (587449)   +6 more
core   +1 more source

Structural T‐Cell Receptor Analysis in the Age of Machine Learning

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT The development of highly accurate deep learning models for protein structure prediction has transformed the landscape of T‐cell receptor (TCR) structure data, which can now be accessed at repertoire scale. We provide a perspective on the growing field of structural TCR immunoinformatics, summarizing core principles of TCR structural biology ...
Nele P. Quast, Matthew I. J. Raybould, Charlotte M. Deane   +2 more
wiley   +1 more source

DataSheet_3_“Immunoinformatic Identification of T-Cell and B-Cell Epitopes From Giardia lamblia Immunogenic Proteins as Candidates to Develop Peptide-Based Vaccines Against Giardiasis”.pdf

, 2021
Giardiasis is one of the most common gastrointestinal infections worldwide, mainly in developing countries. The etiological agent is the Giardia lamblia parasite.
Thania Garzon (11611648), Efrain Alday (11611657), Carlos Velazquez (11611660), Ramón Enrique Robles-Zepeda (11175906), David Ortega-Tirado (11611651), Gloria Lopez-Romero (11611654), Adriana Garibay-Escobar (587449)   +6 more
core   +1 more source

An immunoinformatic investigation on Rift Valley fever virus protein reveals possible epitopes for vaccines

Journal of Infection in Developing Countries
Introduction: This immunoinformatic study identified potential epitopes from the envelopment polyprotein (Gn/Gc) of Rift Valley fever virus (RVFV), a pathogenic virus causing severe fever in humans and livestock.
Tanjir Hosen, Saaimatul Huq, Mohammad Abdullah-Al-Shoeb, Shahidul Islam, Muhammad Abul Kalam Azad   +4 more
doaj   +1 more source

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík, Mikolaj Adamek, Tomáš Korytář   +2 more
wiley   +1 more source

IMGT-ONTOLOGY for immunogenetics and immunoinformatics.

In silico biology, 2003
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d ...
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Bosc, Nathalie, Folch, Géraldine, Guiraudou, Delphine, Jabado-Michaloud, Joumana, Magris, Séverine, Scaviner, Dominique, Thouvenin, Valérie, Combres, Kora, Girod, David, Jeanjean, Stéphanie, Protat, Céline, Yousfi-Monod, Mehdi, Duprat, Elodie, Kaas, Quentin, Pommié, Christelle, Chaume, Denys, Lefranc, Gérard   +19 more
openaire   +6 more sources

Immunoinformatic docking approach for the analysis of KIR3DL1/HLA-B interaction [PDF]

, 2013
KIR3DL1 is among the most interesting receptors studied, within the killer immunoglobulin receptor (KIR) family. Human leukocyte antigen (HLA) class I Bw4 epitope inhibits strongly Natural Killer (NK) cell's activity through interaction with KIR3DL1 ...
Amicosante, M, Carla Montesano, Vittorio Colizzi, Atanas Patronov, Colizzi, V, Alba Grifoni, MONTESANO, CARLA, Montesano, C, Patronov, A, COLIZZI, VITTORIO, Grifoni, A, Massimo Amicosante, AMICOSANTE, MASSIMO   +12 more
core   +1 more source

Combined Immunoinformatics to Design and Evaluate a Multi-Epitope Vaccine Candidate against Streptococcus suis Infection

Vaccines
Streptococcus suis (S. suis) is a zoonotic pathogen with multiple serotypes, and thus, multivalent vaccines generating cross-protection against S. suis infections are urgently needed to improve animal welfare and reduce antibiotic abuse.
Song Liang, Shidan Zhang, Yinli Bao, Yumin Zhang, Xinyi Liu, Huochun Yao, Guangjin Liu   +6 more
doaj   +1 more source