Results 41 to 50 of about 2,266 (210)

Immunoinformatics: Predicting Peptide–MHC Binding [PDF]

Annual Review of Biomedical Data Science, 2020
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation by MHC molecules to T cells, a process that is central to adaptive immune responses to infections and cancer.
Nielsen, Morten, Andreatta, Massimo, Peters, Bjoern, Buus, Søren   +3 more
openaire   +4 more sources

Immunoinformatic analysis of the whole proteome for vaccine design: An application to Clostridium perfringens

, 2022
Clostridium perfringens is a dangerous bacterium and known biological warfare weapon associated with several diseases, whose lethal toxins can produce necrosis in humans. However, there is no safe and fully effective vaccine against C.
Silva, Yshoner, Jiménez-Avalos, Gabriel, Romaní, Ana C., Lopez Lapa, Rainer M., Requena, David, Soto, Luis F., Ordinola-Ramirez, Carla M.   +6 more
core   +1 more source

Identification of CD4+ T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking [PDF]

, 2021
One major reason for the lack of clinical success of Staphylococcus aureus vaccine candidates is the inability of the antigens to develop a CD4+ T cell-mediated immune response. Hence, it is important to identify CD4+ T cell anti¬gens from S. aureus. CD4+
Arun Kumar, Dileep Francis, Francis, D., Sadasivan Chittalakkottu, Kumar, A., Chittalakkottu, S.   +5 more
core   +1 more source

Design of a Multi-Epitope Vaccine against Histoplasma capsulatum through Immunoinformatics Approaches

Journal of Fungi
Histoplasmosis is a widespread systemic disease caused by Histoplasma capsulatum, prevalent in the Americas. Despite its significant morbidity and mortality rates, no vaccines are currently available.
Pedro Henrique Marques, Sandeep Tiwari, Andrei Giacchetto Felice, Arun Kumar Jaiswal, Flávia Figueira Aburjaile, Vasco Azevedo, Mario León Silva-Vergara, Kennio Ferreira-Paim, Siomar de Castro Soares, Fernanda Machado Fonseca   +9 more
doaj   +1 more source

A novel therapeutic multiepitope vaccine based on oncoprotein E6 and E7 of HPV 16 and 18: An in silico approach [PDF]

BioImpacts
Introduction: The current vaccine strategies to prevent cervical cancer are effective only for individuals unexposed to HPV, lacking therapeutic effects against pre-existing infections.
Sari Eka Pratiwi, Ysrafil Ysrafil, Mardhia Mardhia, Mahyarudin Mahyarudin, Muhammad Inam Ilmiawan, Heru Fajar Trianto, Delima Fajar Liana, Yuri Amia   +7 more
doaj   +1 more source

AntigenDB: an immunoinformatics database of pathogen antigens [PDF]

Nucleic Acids Research, 2009
The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite.
Hifzur Rahman Ansari, Darren R. Flower, G. P. S. Raghava   +2 more
openaire   +4 more sources

Immunoinformatic analysis and immunogenicity ranking of R. prowazekii proteins.

, 2013
Immunoinformatic analysis and immunogenicity ranking of R. prowazekii proteins.
Gustavo Valbuena (413598), Yenny Goez (413599), Michal Gazi (471397), Maria A. Cespedes (471399), Paula Correa (471401), Erika Caro-Gomez (471398), Marylin Hidalgo (471400)   +6 more
core   +1 more source

DataSheet_2_“Immunoinformatic Identification of T-Cell and B-Cell Epitopes From Giardia lamblia Immunogenic Proteins as Candidates to Develop Peptide-Based Vaccines Against Giardiasis”.pdf

, 2021
Giardiasis is one of the most common gastrointestinal infections worldwide, mainly in developing countries. The etiological agent is the Giardia lamblia parasite.
Thania Garzon (11611648), Efrain Alday (11611657), Carlos Velazquez (11611660), Ramón Enrique Robles-Zepeda (11175906), David Ortega-Tirado (11611651), Gloria Lopez-Romero (11611654), Adriana Garibay-Escobar (587449)   +6 more
core   +1 more source

Cocktail Antigen Presenting Peptide Vaccine Development for Nipah Virus: An Immunoinformatic Approach to Indian and Malaysian Strain

Journal of Pure and Applied Microbiology
Nipah virus (NiV) is an emerging zoonotic pathogen of global concern, causing serious life-threatening illness in humans. The first outbreak was reported from Malaysia in 1998. The virus is classified under the family Paramyxoviridae. Geographically, the
Naseera Kannanthodi Pariyapurath, Sarika Baburajan Pillai, Kavitha Dhandapani, Rahulgandhi Pachamuthu, Shivanandhappa Kukkaler Channappa, Ananda Arona Premkumar, Maghimaa Mathanmohun, Pachamuthu Balakrishnan, Sathish Sankar, Selvaraj Jagannathan   +9 more
doaj   +1 more source

Computational Design and Immunoinformatic Analysis of a Broad-Spectrum Edible Multi-Epitope Vaccine Against Salmonella for Poultry. [PDF]

Vet Sci
Salmonellosis remains a persistent threat to global food safety and poultry productivity, compounded by rising antimicrobial resistance. Here, we report the in silico design and immunoinformatic validation of a broad-spectrum, edible multi-epitope ...
Ramirez-Cando LJ, Mora-Ochoa YI, Castillo JA.   +2 more
europepmc   +2 more sources