Results 31 to 40 of about 2,266 (210)

A comprehensive approach to developing a multi-epitope vaccine against Mycobacterium tuberculosis: from in silico design to in vitro immunization evaluation

Frontiers in Immunology, 2023
IntroductionThe Bacillus Calmette-Guérin (BCG) vaccine, currently used against tuberculosis (TB), exhibits inconsistent efficacy, highlighting the need for more potent TB vaccines.Materials and methodsIn this study, we employed reverse vaccinology ...
Fan Jiang, Fan Jiang, Fan Jiang, Fan Jiang, Yong Han, Yinping Liu, Yong Xue, Peng Cheng, Li Xiao, Wenping Gong   +9 more
doaj   +1 more source

Bioinformatics, Computational Informatics, and Modeling Approaches to the Design of mRNA COVID-19 Vaccine Candidates

Computation, 2022
This article is devoted to applying bioinformatics and immunoinformatics approaches for the development of a multi-epitope mRNA vaccine against the spike glycoproteins of circulating SARS-CoV-2 variants in selected African countries.
Olugbenga Oluseun Oluwagbemi, Elijah K. Oladipo, Olatunji M. Kolawole, Julius K. Oloke, Temitope I. Adelusi, Boluwatife A. Irewolede, Emmanuel O. Dairo, Ayodele E. Ayeni, Kehinde T. Kolapo, Olawumi E. Akindiya, Jerry A. Oluwasegun, Bamigboye F. Oluwadara, Segun Fatumo   +12 more
doaj   +1 more source

Human Coronavirus Spike Protein Based Multi-Epitope Vaccine against COVID-19 and Potential Future Zoonotic Coronaviruses by Using Immunoinformatic Approaches

, 2022
Zoonotic coronaviruses (CoV) have emerged twice and have caused severe respiratory diseases in humans. Due to the frequent outbreaks of different human coronaviruses (HCoVs), the development of a pan-HCoV vaccine is of great importance. Various conserved
Faryal Mehwish Awan, Zulqarnain Baloch, Aqsa Ikram, Ayesha Obaid, Obaid, Ayesha, Qureshi, Javed Anver, Naz, Anam, Anam Naz, Javed Anver Qureshi, Awan, Faryal Mehwish, Saba Shamim, Baloch, Zulqarnain, Khadija Gilani, Rauff, Bisma, Bisma Rauff, Shamim, Saba, Gilani, Khadija, Ikram, Aqsa   +17 more
core   +1 more source

Sph2_(176–191) and Sph2_(446–459): Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires

Vaccines, 2023
Sphingomyelin is a major constituent of eukaryotic cell membranes, and if degraded by bacteria sphingomyelinases may contribute to the pathogenesis of infection.
Laura Sant’Anna Ataides, Fernanda de Moraes Maia, Fernando Paiva Conte, Lourdes Isaac, Angela Silva Barbosa, Josué da Costa Lima-Junior, Kátia Eliane Santos Avelar, Rodrigo Nunes Rodrigues-da-Silva   +7 more
doaj   +1 more source

DataSheet1_An immunoinformatic approach to assessing the immunogenic capacity of alpha-neurotoxins in elapid snake venoms.xlsx

, 2023
Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs), which are proteins that cause post-synaptic blockade and paralysis in snakebite envenoming.
Kae Yi Tan (3174875), Choo Hock Tan (7535330), Choon Han Heh (3269013), Yi Wei Chan (11876198)   +3 more
core   +1 more source

Development and evaluation of a multi-epitope subunit vaccine against group B Streptococcus infection

Emerging Microbes and Infections, 2022
Streptococcus agalactiae (Group B Streptococcus, GBS) is a multi-host pathogen, even causing life-threatening infections in newborns. Vaccination with GBS crossed serotypes vaccine is one of the best options for long-term infection control. Here we built
Yumin Zhang, Song Liang, Shiyu Zhang, Shidan Zhang, Yong Yu, Huochun Yao, Yongjie Liu, Wei Zhang, Guangjin Liu   +8 more
doaj   +1 more source

Immunoinformatics: A Basic Bibliometric Analysis [PDF]

ImmunoAnalysis, 2021
Background: Traditionally, immunologists have been using experimental methods for a long time, which have generated functional, clinical and epidemiological data. So, it is inevitable to develop and apply novel computational approaches to collect, store, analyze, and report the latent knowledge behind these data.
Elaheh Rahimpour, Taha Samad-Soltani
openaire   +2 more sources

Immunoinformatic evaluation of multiple epitope ensembles as vaccine candidates:E coli 536 [PDF]

, 2012
Epitope prediction is becoming a key tool for vaccine discovery. Prospective analysis of bacterial and viral genomes can identify antigenic epitopes encoded within individual genes that may act as effective vaccines against specific pathogens.
Rai, Jade, Lok, Ka In, Mann, Harvinder, Patel, Pritesh, Mok, Chun Yin, Flower, Darren R, Noor, Mohammed   +6 more
core   +1 more source

Immunoinformatic analysis of glycoprotein from bovine ephemeral fever virus

Biomedical and Biotechnology Research Journal, 2018
Background: Bovine ephemeral fever virus (BEFV) is an arthropod-borne virus that is highly infective for cattle and water buffalo. The infection has important economic losses and is common in tropical and subtropical regions.
Mehran Bakhshesh, Mohammad Mehdi Ranjbar, Shokoofeh Almasi   +2 more
doaj   +1 more source

FRED 2: an immunoinformatics framework for Python [PDF]

Bioinformatics, 2016
Abstract Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats
Benjamin Schubert, Mathias Walzer, Hans-Philipp Brachvogel, András Szolek, Christopher Mohr, Oliver Kohlbacher   +5 more
openaire   +4 more sources