Results 11 to 20 of about 2,266 (210)
Designing a Multi-Epitope Vaccine Against MPXV and HIV Based on an Immunoinformatic Approach [PDF]
International Journal of Molecular SciencesIn the current global health environment, the spread of the monkeypox virus (MPXV) and the persistent threat of human immunodeficiency virus (HIV) have become critical public health challenges.
Weijin Huang, Siwen Wu
exaly +3 more sources
Whole-genome immunoinformatic analysis of F. tularensis: predicted CTL epitopes clustered in hotspots are prone to elicit a T-cell response. [PDF]
PLoS ONE, 2011 The cellular arm of the immune response plays a central role in the defense against intracellular pathogens, such as F. tularensis. To date, whole genome immunoinformatic analyses were limited either to relatively small genomes (e.g.
Anat Zvi +4 more
doaj +2 more sources
Immunoinformatic Analysis of Human Thyroglobulin [PDF]
Cybernetics and Information Technologies, 2020 The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens ...
Doytchinova Irini +2 more
doaj +2 more sources
Viruses, 2023 The Nucleocapsid (N) protein is highlighted as the main target for COVID-19 diagnosis by antigen detection due to its abundance in circulation early during infection.
Rodrigo N. Rodrigues-da-Silva +7 more
doaj +1 more source
Vaccines, 2022 Enterobacter cloacae (EC) is a significant emerging pathogen that is occasionally associated with lung infection, surgical site infection, urinary infection, sepsis, and outbreaks in neonatal intensive care units.
Wafa Abdullah I. Al-Megrin +6 more
doaj +1 more source
Immunoinformatic-driven design of a multi-epitope vaccine against <i>Helicobacter</i> <i>pylori</i>. [PDF]
Biochem Biophys RepHelicobacter pylori (H. pylori) is present in the gastric mucosa of approximately half of the global population and is classified as a definitive type I carcinogen. Developing a logical and effective vaccine against H. pylori remains a critical need.
Rahimi-Farsi N +6 more
europepmc +2 more sources
Frontiers in Immunology, 2022 The therapeutic targeting of the immune system, for example in vaccinology and cancer treatment, is a challenging task and the subject of active research.
Marcus Fabiano de Almeida Mendes +10 more
doaj +1 more source
INDI – Integrated Nanobody Database for Immunoinformatics [PDF]
Nucleic Acids Research, 2021 Abstract Nanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical ...
Piotr Deszynski +7 more
openaire +4 more sources
Immunoinformatic-based prediction of candidate epitopes for the diagnosis and control of paratuberculosis (Johne’s disease) [PDF]
, 2020 Paratuberculosis is an infectious disease of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). MAP is an intracellular pathogen with a possible zoonotic potential since it has been successfully isolated from the intestine and blood ...
Piras C. +8 more
core +2 more sources
An In Silico Deep Learning Approach to Multi-Epitope Vaccine Design: A Hepatitis E Virus Case Study
Vaccines, 2023 Hepatitis E Virus (HEV) is a major cause of acute and chronic hepatitis. The severity of HEV infection increases manyfold in pregnant women and immunocompromised patients.
Aqsa Ikram +6 more
doaj +1 more source