Results 21 to 30 of about 2,266 (210)

Identification of a Potential Vaccine against Treponema pallidum Using Subtractive Proteomics and Reverse-Vaccinology Approaches

Vaccines, 2022
Syphilis, a sexually transmitted infection, is a deadly disease caused by Treponema pallidum. It is a Gram-negative spirochete that can infect nearly every organ of the human body. It can be transmitted both sexually and perinatally.
Siyab Khan, Muhammad Rizwan, Adnan Zeb, Muhammad Alaa Eldeen, Said Hassan, Ashfaq Ur Rehman, Refaat A. Eid, Mohamed Samir A. Zaki, Ghadeer M. Albadrani, Ahmed E. Altyar, Nehal Ahmed Talaat Nouh, Mohamed M. Abdel-Daim, Amin Ullah   +12 more
doaj   +1 more source

Immunoinformatics: an integrated scenario [PDF]

Immunology, 2010
SummaryGenome sequencing of humans and other organisms has led to the accumulation of huge amounts of data, which include immunologically relevant data. A large volume of clinical data has been deposited in several immunological databases and as a result immunoinformatics has emerged as an important field which acts as an intersection between ...
Namrata, Tomar, Rajat K, De
openaire   +2 more sources

Design of a Multi-Epitope Vaccine against Tropheryma whipplei Using Immunoinformatics and Molecular Dynamics Simulation Techniques

Vaccines, 2022
Whipple’s disease is caused by T. whipplei, a Gram-positive pathogenic bacterium. It is considered a persistent infection affecting various organs, more likely to infect males.
Thamer H. Albekairi, Abdulrahman Alshammari, Metab Alharbi, Amal F. Alshammary, Muhammad Tahir ul Qamar, Tasneem Anwar, Saba Ismail, Bilal Shaker, Sajjad Ahmad   +8 more
doaj   +1 more source

Combined immunoinformatic approaches with computational biochemistry for development of subunit-based vaccine against Lawsonia intracellularis. [PDF]

PLoS One
Lawsonia intracellularis (LI) are obligate intracellular bacteria and the causative agent of proliferative hemorrhagic enteropathy that significantly impacts the health of piglets and the profitability of the swine industry.
Khatooni Z, Broderick G, Anand SK, Wilson HL.   +3 more
europepmc   +2 more sources

Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis

Frontiers in Immunology, 2023
IntroductionIdentification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for
Guadalupe Nibeyro, Veronica Baronetto, Juan I. Folco, Pablo Pastore, Maria Romina Girotti, Laura Prato, Gabriel Morón, Gabriel Morón, Hugo D. Luján, Hugo D. Luján, Elmer A. Fernández, Elmer A. Fernández, Elmer A. Fernández   +12 more
doaj   +1 more source

Immunoinformatics Comes of Age

PLoS Computational Biology, 2006
With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web interfaces.
Bette T. Korber, Montiago LaBute, Karina Yusim   +2 more
openaire   +4 more sources

Regulation of Host Immune Response against Enterobacter cloacae Proteins via Computational mRNA Vaccine Design through Transcriptional Modification

Microorganisms, 2022
Enterobacter cloacae is mainly responsible for sepsis, urethritis, and respiratory tract infections. These bacteria may affect the transcription of the host and particularly their immune system by producing changes in their epigenetics.
Muhammad Naveed, Khizra Jabeen, Rubina Naz, Muhammad Saad Mughal, Ali A. Rabaan, Muhammed A. Bakhrebah, Fahad M. Alhoshani, Mohammed Aljeldah, Basim R. Al Shammari, Mohammed Alissa, Amal A. Sabour, Rana A. Alaeq, Maha A. Alshiekheid, Mohammed Garout, Mohammed S. Almogbel, Muhammad A. Halwani, Safaa A. Turkistani, Naveed Ahmed   +17 more
doaj   +1 more source

Immunoinformatic approach employing modeling and simulation to design a novel vaccine construct targeting MDR efflux pumps to confer wide protection against typhoidal Salmonella serovars

, 2021
Overcoming multi drug resistance is one of the crucial challenges to control enteric typhoid fever caused by Salmonella typhi and Salmonella paratyphi. Overexpression of efflux pumps predominantly causes drug resistance in microorganisms.
Jyotirmayee Dey (11359419), S Lata (11359431), Puspasree Puhan (11359422), Santosh Kumar Panda (11359428), Soumya Ranjan Mahapatra (9418130), Nirmal Kumar Mohakud (11359425), Mrutyunjay Suar (132783), Gajraj Singh Kushwaha (9603686), Namrata Misra (472652)   +8 more
core   +1 more source

Identification and In Silico Characterization of a Conserved Peptide on Influenza Hemagglutinin Protein: A New Potential Antigen for Universal Influenza Vaccine Development

Nanomaterials, 2023
Antigenic changes in surface proteins of the influenza virus may cause the emergence of new variants that necessitate the reformulation of influenza vaccines every year.
Atin Khalaj-Hedayati, Seyedehmaryam Moosavi, Otilia Manta, Mohamed H. Helal, Mohamed M. Ibrahim, Zeinhom M. El-Bahy, Ganden Supriyanto   +6 more
doaj   +1 more source

Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross-protection against COVID-19 [PDF]

, 2020
Envelope protein of coronaviruses is a structural protein existing in both monomeric and homo-pentameric form. It has been related to a multitude of roles including virus infection, replication, dissemination and immune response stimulation.
Bonizzi L., Soggiu A., Babini G., Roncada P., Urbani A., Britti D., De Maio F., Zecconi A., Sanguinetti M., Tilocca B.   +9 more
core   +3 more sources