Results 1 to 10 of about 4,743 (216)

ImmunoNodes – graphical development of complex immunoinformatics workflows [PDF]

BMC Bioinformatics, 2017
Background Immunoinformatics has become a crucial part in biomedical research. Yet many immunoinformatics tools have command line interfaces only and can be difficult to install.
Benjamin Schubert, Luis de la Garza, Christopher Mohr, Mathias Walzer, Oliver Kohlbacher   +4 more
doaj   +6 more sources

AntigenDB: an immunoinformatics database of pathogen antigens [PDF]

Nucleic Acids Research, 2009
The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite.
Hifzur Rahman Ansari, Darren R. Flower, Gajendra P. S. Raghava   +2 more
openalex   +5 more sources

TRain: T-cell receptor automated immunoinformatics. [PDF]

BMC Bioinformatics
BACKGROUND: The scarcity of available structural data makes characterizing the binding of T-cell receptors (TCRs) to peptide-Major Histocompatibility Complexes (pMHCs) very challenging. The recent surge in sequencing data makes TCRs an ideal target for protein structure modeling.
Seamann A, Bennett-Boehm M, Ehrlich R, Gil A, Selin L, Ghersi D.   +5 more
europepmc   +3 more sources

In Silico-Based Investigation of the Immunogenicity and Biochemical Attributes of <i>Toxoplasma gondii</i> Apical Membrane Antigen 1 (TgAMA1). [PDF]

J Parasitol Res
Background: Apical membrane antigen 1 (AMA1) is a highly conserved microneme protein in apicomplexan parasites. In this study, immunoinformatics tools and in silico protein structure prediction were used to characterize the structure, physicochemical properties, posttranslational modification sites, immunogenic epitopes, allergenicity, and immune ...
Foroutan M, Ghaffari AD, Ghaffarifar F, Karimipour-Saryazdi A, Birgani AA, Majidiani H, Cortes H, Elsheikha HM.   +7 more
europepmc   +2 more sources

ImmunoInformatics: at the crossroads between immunology and informatics, and beyond

ImmunoInformatics, 2021
Niels Halama, Doron Levy
doaj   +3 more sources

Scifer: An R/Bioconductor package for large-scale integration of Sanger sequencing and flow cytometry data of index-sorted single cells [PDF]

ImmunoInformatics
Sanger sequencing remains widely used in various experimental contexts, often in combination with flow cytometry for indexing specific cell populations.
Rodrigo Arcoverde Cerveira, Klara Lenart, Marcel Martin, Matthew James Hinchcliff, Fredrika Hellgren, Kewei Ye, Juliana Assis Geraldo, Taras Kreslavsky, Sebastian Ols, Karin Loré   +9 more
doaj   +2 more sources

Immunoinformatics: A Basic Bibliometric Analysis [PDF]

ImmunoAnalysis, 2021
Background: Traditionally, immunologists have been using experimental methods for a long time, which have generated functional, clinical and epidemiological data. So, it is inevitable to develop and apply novel computational approaches to collect, store, analyze, and report the latent knowledge behind these data.
Elaheh Rahimpour, Taha Samad-Soltani
openaire   +3 more sources

The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase

Viruses, 2022
Previously, we reported that an HIV-1 variant containing Met-to-Ile change at codon 50 and Val-to-Ile mutation at codon 151 of integrase (IN), HIV(IN:M50I/V151I), was an impaired virus.
Tomozumi Imamichi, Qian Chen, Ming Hao, Weizhong Chang, Jun Yang   +4 more
doaj   +1 more source

INDI – Integrated Nanobody Database for Immunoinformatics [PDF]

Nucleic Acids Research, 2021
AbstractNanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical viability of this format.
Piotr Deszyński, Jakub Młokosiewicz, Adam Volanakis, Igor Jaszczyszyn, Natalie Castellana, Stefano Bonissone, Rajkumar Ganesan, Konrad Krawczyk   +7 more
openaire   +5 more sources

A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

Viruses, 2021
We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due ...
Jun Yang, Ming Hao, Muhammad A. Khan, Muhammad T. Rehman, Helene C. Highbarger, Qian Chen, Suranjana Goswami, Brad T. Sherman, Catherine A. Rehm, Robin L. Dewar, Weizhong Chang, Tomozumi Imamichi   +11 more
doaj   +1 more source