Results 1 to 10 of about 3,721 (99)

Correction: Manganese mediates antiviral effects by driving an ATM-TBK1 phosphorylation signaling pathway [PDF]

Frontiers in Immunology
Hongyan Sui, Rosana Wiscovitch-Russo, Silvia Cachaco, Silvia Cachaco, Jun Yang, Whitney Bruchey, Sylvain Laverdure, Qian Chen, Tomozumi Imamichi   +8 more
doaj   +2 more sources

The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase

Viruses, 2022
Previously, we reported that an HIV-1 variant containing Met-to-Ile change at codon 50 and Val-to-Ile mutation at codon 151 of integrase (IN), HIV(IN:M50I/V151I), was an impaired virus.
Tomozumi Imamichi, Qian Chen, Ming Hao, Weizhong Chang, Jun Yang   +4 more
doaj   +1 more source

Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

iScience, 2022
Summary: Trace metals are essential for various physiological processes, but their roles in innate immunity have not been fully explored. Here, we found that manganese (Mn) significantly enhanced DNA-mediated IFN-α, IFN-β, and IFN-λ1 production ...
Hongyan Sui, Qian Chen, Jun Yang, Selena Srirattanapirom, Tomozumi Imamichi   +4 more
doaj   +1 more source

A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

Viruses, 2021
We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due ...
Jun Yang, Ming Hao, Muhammad A. Khan, Muhammad T. Rehman, Helene C. Highbarger, Qian Chen, Suranjana Goswami, Brad T. Sherman, Catherine A. Rehm, Robin L. Dewar, Weizhong Chang, Tomozumi Imamichi   +11 more
doaj   +1 more source

Interleukin-27 promotes autophagy in human serum-induced primary macrophages via an mTOR- and LC3-independent pathway

Scientific Reports, 2021
Interleukin-27 (IL-27) is a cytokine that suppresses human immunodeficiency virus (HIV)-1 infection in macrophages and is considered as an immunotherapeutic reagent for infectious diseases.
Sylvain Laverdure, Ziqiu Wang, Jun Yang, Takuya Yamamoto, Tima Thomas, Toyotaka Sato, Kunio Nagashima, Tomozumi Imamichi   +7 more
doaj   +1 more source

Molecular identification, characterization, and antagonistic activity profiling of Bacillus cereus LOCK 1002 along with the in-silico analysis of its presumptive bacteriocins

Journal of Advanced Veterinary and Animal Research, 2022
Objectives: This research aimed to isolate, identify, and characterize a new strain of Bacillus cereus through different molecular biology approaches so that it could be further studied for therapeutic purposes against selective enteric pathogens ...
Samarth Islam, Mithila Farjana, Muhammad Ramiz Uddin, Sharmin Akter, Anika Jabin, Hazika Tuz-Zohura Nafisa, Siam Siraji, A K M Helal Morshed, Fahmida Hoque Rimti, Zannatul Naim, Mohiuddin Sakib, Pallab Sarker, Sabiha Naznin, H.M. Iftekhar Alam, Tanzila Ismail Ema, Mahbuba Siddiquy, Mohammad Habibur Rahman   +16 more
doaj   +1 more source

Point-specific interactions of isovitexin with the neighboring amino acid residues of the hACE2 receptor as a targeted therapeutic agent in suppressing the SARS-CoV-2 influx mechanism

Journal of Advanced Veterinary and Animal Research, 2022
Objective: Despite the development of several vaccines against severe acute respiratory syndrome coronavirus-2, the need for an additional prophylactic agent is evident.
Nourin Ferdausi, Samarth Islam, Fahmida Hoque Rimti, Syeda Tasnim Quayum, Efat Muhammad Arshad, Aashian Ibnat, Tamnia Islam, Adittya Arefin, Tanzila Ismail Ema, Partha Biswas, Dipta Dey, Salauddin Al Azad   +11 more
doaj   +1 more source

Association of pyroptosis and severeness of COVID-19 as revealed by integrated single-cell transcriptome data analysis

ImmunoInformatics, 2022
Cytokine storm and inflammatory cytokine release syndrome are often found to be associated with severe instances of the 2019 coronavirus disease (COVID-19). However, factors that contribute to the development of the COVID-19-associated cytokine storm and
Qian Xu, Yongjian Yang, Xiuren Zhang, James J. Cai   +3 more
doaj   +1 more source

Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction

Frontiers in Immunology, 2020
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies (ADAs) that may result in adverse ...
Carolina Barra, Chloe Ackaert, Birkir Reynisson, Jana Schockaert, Leon Eyrich Jessen, Mark Watson, Anne Jang, Simon Comtois-Marotte, Jean-Philippe Goulet, Sofie Pattijn, Eustache Paramithiotis, Morten Nielsen, Morten Nielsen   +12 more
doaj   +1 more source

Epitope identification of SARS-CoV-2 structural proteins using in silico approaches to obtain a conserved rational immunogenic peptide

ImmunoInformatics, 2022
The short time between the first cases of COVID-19 and the declaration of a pandemic initiated the search for ways to stop the spread of SARS-CoV-2. There are great expectations regarding the development of effective vaccines that protect against all ...
Leonardo Pereira de Araújo, Maria Eduarda Carvalho Dias, Gislaine Cristina Scodeler, Ana de Souza Santos, Letícia Martins Soares, Patrícia Paiva Corsetti, Ana Carolina Barbosa Padovan, Nelson José de Freitas Silveira, Leonardo Augusto de Almeida   +8 more
doaj   +1 more source