Results 11 to 20 of about 4,743 (216)

T cell receptor binding prediction: A machine learning revolution [PDF]

ImmunoInformatics, 2024, 2023
Recent advancements in immune sequencing and experimental techniques are generating extensive T cell receptor (TCR) repertoire data, enabling the development of models to predict TCR binding specificity. Despite the computational challenges due to the vast diversity of TCRs and epitopes, significant progress has been made.
arxiv   +1 more source

Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics [PDF]

Immunity, Inflammation and Disease 10 (2022), e639, 2022
Prominently accountable for the upsurge of COVID-19 cases as the world attempts to recover from the previous two waves, Omicron has further threatened the conventional therapeutic approaches. Omicron is the fifth variant of concern (VOC), which comprises more than 10 mutations in the receptor-binding domain (RBD) of the spike protein. However, the lack
arxiv   +1 more source

Interleukin-27 promotes autophagy in human serum-induced primary macrophages via an mTOR- and LC3-independent pathway

Scientific Reports, 2021
Interleukin-27 (IL-27) is a cytokine that suppresses human immunodeficiency virus (HIV)-1 infection in macrophages and is considered as an immunotherapeutic reagent for infectious diseases.
Sylvain Laverdure, Ziqiu Wang, Jun Yang, Takuya Yamamoto, Tima Thomas, Toyotaka Sato, Kunio Nagashima, Tomozumi Imamichi   +7 more
doaj   +1 more source

Immunoinformatics: an integrated scenario [PDF]

Immunology, 2010
SummaryGenome sequencing of humans and other organisms has led to the accumulation of huge amounts of data, which include immunologically relevant data. A large volume of clinical data has been deposited in several immunological databases and as a result immunoinformatics has emerged as an important field which acts as an intersection between ...
Namrata Tomar, Rajat K. De
openaire   +2 more sources

Molecular identification, characterization, and antagonistic activity profiling of Bacillus cereus LOCK 1002 along with the in-silico analysis of its presumptive bacteriocins

Journal of Advanced Veterinary and Animal Research, 2022
Objectives: This research aimed to isolate, identify, and characterize a new strain of Bacillus cereus through different molecular biology approaches so that it could be further studied for therapeutic purposes against selective enteric pathogens ...
Samarth Islam, Mithila Farjana, Muhammad Ramiz Uddin, Sharmin Akter, Anika Jabin, Hazika Tuz-Zohura Nafisa, Siam Siraji, A K M Helal Morshed, Fahmida Hoque Rimti, Zannatul Naim, Mohiuddin Sakib, Pallab Sarker, Sabiha Naznin, H.M. Iftekhar Alam, Tanzila Ismail Ema, Mahbuba Siddiquy, Mohammad Habibur Rahman   +16 more
doaj   +1 more source

FRED 2: an immunoinformatics framework for Python [PDF]

Bioinformatics, 2016
Abstract Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats
Schubert, Benjamin, Walzer, Mathias, Brachvogel, Hans-Philipp, Szolek, András, Mohr, Christopher, Kohlbacher, Oliver   +5 more
openaire   +3 more sources

Immunoinformatic Analysis of Human Thyroglobulin [PDF]

Cybernetics and Information Technologies, 2020
Abstract The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens, Thyroglobulin (Tg) and Thyroid PerOxidase (TPO).
Irini Doytchinova, Stefan Ivanov, Andrey Tchorbanov   +2 more
openaire   +3 more sources

Point-specific interactions of isovitexin with the neighboring amino acid residues of the hACE2 receptor as a targeted therapeutic agent in suppressing the SARS-CoV-2 influx mechanism

Journal of Advanced Veterinary and Animal Research, 2022
Objective: Despite the development of several vaccines against severe acute respiratory syndrome coronavirus-2, the need for an additional prophylactic agent is evident.
Nourin Ferdausi, Samarth Islam, Fahmida Hoque Rimti, Syeda Tasnim Quayum, Efat Muhammad Arshad, Aashian Ibnat, Tamnia Islam, Adittya Arefin, Tanzila Ismail Ema, Partha Biswas, Dipta Dey, Salauddin Al Azad   +11 more
doaj   +1 more source

Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction

Frontiers in Immunology, 2020
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies (ADAs) that may result in adverse ...
Carolina Barra, Chloe Ackaert, Birkir Reynisson, Jana Schockaert, Leon Eyrich Jessen, Mark Watson, Anne Jang, Simon Comtois-Marotte, Jean-Philippe Goulet, Sofie Pattijn, Eustache Paramithiotis, Morten Nielsen, Morten Nielsen   +12 more
doaj   +1 more source

Immunoinformatics: Predicting Peptide–MHC Binding [PDF]

Annual Review of Biomedical Data Science, 2020
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation by MHC molecules to T cells, a process that is central to adaptive immune responses to infections and cancer.
Søren Buus, Morten Nielsen, Massimo Andreatta, Bjoern Peters, Bjoern Peters   +4 more
openaire   +5 more sources