Results 11 to 20 of about 8,611 (248)

Immunoinformatics: A Basic Bibliometric Analysis [PDF]

ImmunoAnalysis, 2021
Background: Traditionally, immunologists have been using experimental methods for a long time, which have generated functional, clinical and epidemiological data. So, it is inevitable to develop and apply novel computational approaches to collect, store,
Elaheh Rahimpour, Taha Samad-Soltani
doaj   +2 more sources

ImmunoNodes – graphical development of complex immunoinformatics workflows [PDF]

BMC Bioinformatics, 2017
Background Immunoinformatics has become a crucial part in biomedical research. Yet many immunoinformatics tools have command line interfaces only and can be difficult to install.
Benjamin Schubert, Luis de la Garza, Christopher Mohr, Mathias Walzer, Oliver Kohlbacher   +4 more
doaj   +5 more sources

Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter Pylori. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address this public health challenge.
Pasha AVK, Esfandiyari M, Parnian A, Mahboubi-Rabbani M, Bayanati M.   +4 more
europepmc   +2 more sources

Is Toxoplasma gondii-secreted Protein With an Altered Thrombospondin Repeat (TgSPATR) a Potential Candidate for Immunisation? An Immunoinformatics-Based Analysis. [PDF]

Vet Med Sci
Toxoplasma gondii‐secreted protein with an altered thrombospondin repeat was computationally characterised as an immunogenic, non‐allergenic protein carrying multiple B‐ and T‐cell epitopes. Structural validation and immune simulation suggest its strong potential as a vaccine candidate against toxoplasmosis.
Foroutan M, Karimzadeh-Soureshjani E, Ghaffarifar F.   +2 more
europepmc   +2 more sources

Immunoinformatics-Based Multi-Epitope Vaccine Design Against <i>P. falciparum-</i>Causing Malaria: A Computational Approach. [PDF]

Health Sci Rep
ABSTRACT Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible Plasmodium resistance to artemisinin warrants an exploration of new treatment options. This study
Larbi AA, Mensah C, Korankye R, Darkwah AA, Agyemang EB, Ayikpah IY, Kwarteng A.   +6 more
europepmc   +2 more sources

INDI – Integrated Nanobody Database for Immunoinformatics [PDF]

Nucleic Acids Research, 2021
AbstractNanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical viability of this format.
Piotr Deszyński, Jakub Młokosiewicz, Adam Volanakis, Igor Jaszczyszyn, Natalie Castellana, Stefano Bonissone, Rajkumar Ganesan, Konrad Krawczyk   +7 more
openaire   +3 more sources

Immunoinformatics: Predicting Peptide–MHC Binding [PDF]

Annual Review of Biomedical Data Science, 2020
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation by MHC molecules to T cells, a process that is central to adaptive immune responses to infections and cancer.
Nielsen, Morten, Andreatta, Massimo, Peters, Bjoern, Buus, Søren   +3 more
openaire   +4 more sources

Genomic and Immunoinformatics Insights Into a Bovine-Derived Brucella abortus S19 Field Strain: Adaptations Impacting Vaccine Efficacy. [PDF]

Vet Med Sci
This study presents a comprehensive genomic and immunoinformatics analysis of a bovine‐derived Brucella abortus S19 field strain, revealing significant antigenic variations and virulence adaptations impacting vaccine efficacy. These findings provide insights for designing improved vaccines tailored to regional epidemiological needs.
Arslan A, Aktas E, Sezerman OU, Ozbek T.
europepmc   +2 more sources

Immunoinformatics: an integrated scenario [PDF]

Immunology, 2010
SummaryGenome sequencing of humans and other organisms has led to the accumulation of huge amounts of data, which include immunologically relevant data. A large volume of clinical data has been deposited in several immunological databases and as a result immunoinformatics has emerged as an important field which acts as an intersection between ...
Namrata, Tomar, Rajat K, De
openaire   +2 more sources

Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction

Frontiers in Immunology, 2020
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies (ADAs) that may result in adverse ...
Carolina Barra, Chloe Ackaert, Birkir Reynisson, Jana Schockaert, Leon Eyrich Jessen, Mark Watson, Anne Jang, Simon Comtois-Marotte, Jean-Philippe Goulet, Sofie Pattijn, Eustache Paramithiotis, Morten Nielsen, Morten Nielsen   +12 more
doaj   +1 more source