Results 21 to 30 of about 8,611 (248)

Review of Immunoinformatic approaches to in-silico B-cell epitope prediction [PDF]

, 2007
In this paper, the current state of in-silico, B-cell epitope prediction is discussed. Recommendations for improving some of the approaches encountered are outlined, along with the presentation of an entirely novel technique, which uses molecular ...
Rick Reitmaier
core   +2 more sources

A pull-down assay using DNA/RNA-conjugated beads with a customized competition strategy: An effective approach to identify DNA/RNA binding proteins

MethodsX, 2020
Innate immune response is insisted upon detection of foreign intracellular DNA or RNA derived from viruses and bacteria. This reaction is important to initiate an effective protective response for the host cells. This crucial step is induced by cytosolic
Hongyan Sui, Qian Chen, Tomozumi Imamichi   +2 more
doaj   +1 more source

Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity [PDF]

, 2006
Background: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide
Davies, M.N., Drew, M.G.B., Flower, D.R., Hattotuwagama, C.K., Moss, David S.   +4 more
core   +3 more sources

XML in Motion from Genome to Drug [PDF]

, 2007
Information technology (IT) has emerged as a central to the solution of contemporary genomics and drug discovery problems. Researchers involved in genomics, proteomics, transcriptional profiling, high throughput structure determination, and in other sub ...
C. Gopi Mohan
core   +2 more sources

Association of pyroptosis and severeness of COVID-19 as revealed by integrated single-cell transcriptome data analysis

ImmunoInformatics, 2022
Cytokine storm and inflammatory cytokine release syndrome are often found to be associated with severe instances of the 2019 coronavirus disease (COVID-19). However, factors that contribute to the development of the COVID-19-associated cytokine storm and
Qian Xu, Yongjian Yang, Xiuren Zhang, James J. Cai   +3 more
doaj   +1 more source

Editorial: biological ontologies and semantic biology [PDF]

, 2014
As the amount of biological information and its diversity accumulates massively there is a critical need to facilitate the integration of this data to allow new and unexpected conclusions to be drawn from it.
John M. Hancock
core   +2 more sources

Epitope identification of SARS-CoV-2 structural proteins using in silico approaches to obtain a conserved rational immunogenic peptide

ImmunoInformatics, 2022
The short time between the first cases of COVID-19 and the declaration of a pandemic initiated the search for ways to stop the spread of SARS-CoV-2. There are great expectations regarding the development of effective vaccines that protect against all ...
Leonardo Pereira de Araújo, Maria Eduarda Carvalho Dias, Gislaine Cristina Scodeler, Ana de Souza Santos, Letícia Martins Soares, Patrícia Paiva Corsetti, Ana Carolina Barbosa Padovan, Nelson José de Freitas Silveira, Leonardo Augusto de Almeida   +8 more
doaj   +1 more source

Immunization with Hypoallergens of Shrimp Allergen Tropomyosin Inhibits Shrimp Tropomyosin Specific IgE Reactivity [PDF]

, 2014
published_or_final_versio
Chu, KH, Gershwin, LJ, Ho, MHK, Leung, NYH, Leung, PSC, Shu, SA, Wai, CYY   +6 more
core   +1 more source

Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response

ImmunoInformatics, 2021
Response to cancer immunotherapies depends on the complex and dynamic interactions between T cell recognition and killing of cancer cells that are counteracted through immunosuppressive pathways in the tumor microenvironment.
Shuming Zhang, Chang Gong, Alvaro Ruiz-Martinez, Hanwen Wang, Emily Davis-Marcisak, Atul Deshpande, Aleksander S. Popel, Elana J. Fertig   +7 more
doaj   +1 more source

Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination

ImmunoInformatics, 2021
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types.
Kamran Kaveh, Feng Fu
doaj   +1 more source