Results 21 to 30 of about 4,743 (216)

Immunoinformatics Comes of Age

PLoS Computational Biology, 2006
With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web interfaces.
Karina Yusim, Montiago X. LaBute, Bette T. Korber   +2 more
openaire   +4 more sources

Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

iScience, 2022
Summary: Trace metals are essential for various physiological processes, but their roles in innate immunity have not been fully explored. Here, we found that manganese (Mn) significantly enhanced DNA-mediated IFN-α, IFN-β, and IFN-λ1 production ...
Hongyan Sui, Qian Chen, Jun Yang, Selena Srirattanapirom, Tomozumi Imamichi   +4 more
doaj  

Recent advances in T-cell receptor repertoire analysis: Bridging the gap with multimodal single-cell RNA sequencing

ImmunoInformatics, 2022
T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating cytokines or regulation of tolerance, collectively resulting in an effective control of immune-related disease.
Sebastiaan Valkiers, Nicky de Vrij, Sofie Gielis, Sara Verbandt, Benson Ogunjimi, Kris Laukens, Pieter Meysman   +6 more
doaj  

T-cell epitope vaccine design by immunoinformatics [PDF]

Open Biology, 2013
Vaccination is generally considered to be the most effective method of preventing infectious diseases. All vaccinations work by presenting a foreign antigen to the immune system in order to evoke an immune response. The active agent of a vaccine may be intact but inactivated (‘attenuated’) forms of the causative pathogens (bacteria or viruses), or ...
Irini Doytchinova, Atanas Patronov
openaire   +4 more sources

The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions

ImmunoInformatics, 2023
The COVID-19 pandemic has revealed the need for the increased integration of modelling and data analysis to public health, experimental, and clinical studies.
Sonia Gazeau, Xiaoyan Deng, Hsu Kiang Ooi, Fatima Mostefai, Julie Hussin, Jane Heffernan, Adrianne L. Jenner, Morgan Craig   +7 more
doaj  

Design and expression of TolC as a recombinant protein vaccine against Shigella flexneri and evaluation of immunogenic response in mice [PDF]

arXiv, 2023
Background: Shigella is one of the major cause of dysenteric diarrhea, which is known shigelosis. Shigelosis causes 160,000 deaths annually of diarrheal disease in a global scale especially children less than 5 years old. No licensed vaccine is available against shigelosis, therefore, efforts for develop an effective and safe vaccine against shigella ...
arxiv  

Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the antiviral effect via different mechanisms in the individual cell-dependent manner

Frontiers in Immunology
IntroductionInterleukin (IL)-27 is an anti-viral cytokine. IL-27-treated monocyte-derived macrophages (27-Mac) suppressed HIV replication. Macrophages are generally divided into two subtypes, M1 and M2 macrophages.
Tomozumi Imamichi, Jun Yang, Qian Chen, Suranjana Goswami, Mayra Marquez, Udeshika Kariyawasam, Homa Nath Sharma, Rosana Wiscovitch-Russo, Xuan Li, Akihiro Aioi, Joseph W. Adelsberger, Weizhong Chang, Jeanette Higgins, Hongyan Sui   +13 more
doaj   +1 more source

Antigenic Protein Screening and Design of Multi‐Epitope Vaccine Against Lactococcus garvieri and Streptococcus iniae for Combating Lactococcosis and Streptococcosis in Fish

Veterinary Medicine and Science, Volume 11, Issue 4, July 2025.
The image depicts the computational identification of B cell epitopes from Lactococcus garvieae and Streptococcus iniae, leading to the design of an epitope‐based vaccine for fish. It features a stylised fish with the targeted bacteria and illustrates the process of identifying B cell epitopes using bioinformatics tools.
Ramesh Ranjbar, Abbas Doosti, Mostafa Shakhsi‐Niaei   +2 more
wiley   +1 more source

CelltrackR: An R package for fast and flexible analysis of immune cell migration data

ImmunoInformatics, 2021
Visualization of cell migration via time-lapse microscopy has greatly advanced our understanding of the immune system. However, subtle differences in migration dynamics are easily obscured by biases and imaging artifacts.
Inge M.N. Wortel, Annie Y. Liu, Katharina Dannenberg, Jeffrey C. Berry, Mark J. Miller, Johannes Textor   +5 more
doaj  

A Genome‐Wide Screening of Novel Immunogenic TrLSDV103 Protein of Lumpy Skin Disease Virus and Its Application for DIVA

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Using the VirScan platform covering 4522 LSDV protein sequences, sera from 20 LSDV‐infected and 20 GTPV‐vaccinated cattle were used to screen phage libraries. Sequencing and bioinformatics analyses revealed peptides covering the TrLSDV103 protein. The candidate antigen was subsequently expressed, confirmed for its DIVA capability, and used to develop ...
Xinwei Yuan, Junhua Dong, Zhijie Xiang, Qian Zhang, Pan Tao, Aizhen Guo   +5 more
wiley   +1 more source