Results 31 to 40 of about 4,743 (216)

<p>Immunoinformatics and Vaccine Development: An Overview</p>

ImmunoTargets and Therapy, 2020
The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system.
Angus Nnamdi Oli, Wilson Okechukwu Obialor, Martins Ositadimma Ifeanyichukwu, Damian Chukwu Odimegwu, Jude Nnaemeka Okoyeh, George Ogonna Emechebe, Samson Adedeji Adejumo, Gordon C Ibeanu   +7 more
openaire   +4 more sources

Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: A systematic literature review

ImmunoInformatics, 2021
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important genetic feature affecting 10–15% of colorectal cancer (CRC) patients.
Amelie Echle, Narmin Ghaffari Laleh, Peter L. Schrammen, Nicholas P. West, Christian Trautwein, Titus J. Brinker, Stephen B. Gruber, Roman D. Buelow, Peter Boor, Heike I. Grabsch, Philip Quirke, Jakob N. Kather   +11 more
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Beyond Efficacy: Ensuring Safety in Peptide Therapeutics through Immunogenicity Assessment

Journal of Peptide Science, Volume 31, Issue 6, June 2025.
Peptides are increasingly used in diagnosis and treatment due to their selectivity and low side effects. Over 11% of FDA‐approved drugs from 2016 to 2024 were synthetic peptides. However, immunogenicity—an adverse immune response—can limit their safety and efficacy.
Koulla Achilleos, Christos Petrou, Vicky Nicolaidou, Yiannis Sarigiannis   +3 more
wiley   +1 more source

Improving immunovirotherapies: the intersection of mathematical modelling and experiments

ImmunoInformatics, 2022
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols represent a promising treatment strategy for a range of cancers and offer many advantages over conventional anti-cancer therapies.
Christine E. Engeland, Johannes P.W. Heidbuechel, Robyn P. Araujo, Adrianne L. Jenner   +3 more
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Plant‐Based Mycetoma Inhibitors Targeting the 50S Ribosomal Protein of Nocardia brasiliensis: In Silico Approach

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
In‐silico drug discovery pipeline for Mycetoma caused by Nocardia brasiliensis. A library of 1034 phytocompounds was screened to identify potent inhibitors, with Parviflorone F showing strong binding and stability against the 50S ribosomal unit. Molecular dynamics confirmed its inhibitory potential, offering a promising therapeutic candidate.
Sandra Jose, Manjunathan Jagadeesan, Meenambiga Setti Sudharsan, Pasiyappazham Ramasamy, Shyamala Gowri, Muthu Thiruvengadam, Sowmya Hari, Baskar Venkidasamy   +7 more
wiley   +1 more source

Marburg Virus Disease: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami   +4 more
wiley   +1 more source

Benchmarking immunoinformatic tools for the analysis of antibody repertoire sequences [PDF]

Bioinformatics, 2019
Abstract Summary Antibody repertoires reveal insights into the biology of the adaptive immune system and empower diagnostics and therapeutics. There are currently multiple tools available for the annotation of antibody sequences.
Lmar Babrak, Sai T. Reddy, Mikhail Shugay, Erand Smakaj, William D. Lees, Victor Greiff, Vendi Grobelsek, Johannes Trück, Mats Ohlin, Branden J. Olson, Branden J. Olson, Susanna Marquez, Igor Edmondo Paolo D'angelo, Deniz Tosoni, Bryan Briney, Christopher Galli, Enkelejda Miho   +16 more
openaire   +6 more sources

Designing and Cloning of the Gene Vaccine Carrying the Viral Haemorrhagic Septicaemia Multi‐Epitope Gene in the pNZ8121 Secretion Vector

Veterinary Medicine and Science, Volume 11, Issue 3, May 2025.
Viral haemorrhagic septicaemia virus (VHSV) immunogenic epitopes were used to design a multi‐epitope vaccine with adjuvant. The vaccine's properties, structure and TLR‐4 interaction were analysed via computational methods. Optimized nucleotide sequences were created for Lactococcus lactis expression.
Ramin Shukripour, Abbas Doosti, Mohsen Forouzanfar, Mojtaba Jafarinia   +3 more
wiley   +1 more source

Immunoinformatics and epitope prediction in the age of genomic medicine [PDF]

Genome Medicine, 2015
Immunoinformatics involves the application of computational methods to immunological problems. Prediction of B- and T-cell epitopes has long been the focus of immunoinformatics, given the potential translational implications, and many tools have been developed.
Oliver Kohlbacher, Oliver Kohlbacher, Linus Backert   +2 more
openaire   +3 more sources

A pull-down assay using DNA/RNA-conjugated beads with a customized competition strategy: An effective approach to identify DNA/RNA binding proteins

MethodsX, 2020
Innate immune response is insisted upon detection of foreign intracellular DNA or RNA derived from viruses and bacteria. This reaction is important to initiate an effective protective response for the host cells. This crucial step is induced by cytosolic
Hongyan Sui, Qian Chen, Tomozumi Imamichi   +2 more
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