Results 31 to 40 of about 8,611 (248)

The antibody loci of the domestic goat (Capra hircus) [PDF]

, 2018
The domestic goat (Capra hircus) is an important ruminant species both as a source of antibody-based reagents for research and biomedical applications and as an economically important animal for agriculture, particularly for developing nations that ...
Bickhart, Derek M., Hammond, John A., Philp, Rebecca L., Schwartz, John C., Smith, Timothy P.L.   +4 more
core   +1 more source

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

ImmunoInformatics, 2022
The Omicron (BA.1/B.1.1.529) variant of SARS-CoV-2 harbors an alarming 37 mutations on its spike protein, reducing the efficacy of current COVID-19 vaccines. In this study, we identified CD8+ and CD4+ T cell epitopes from SARS-CoV-2 S protein mutants. To
Simone Parn, Kush Savsani, Sivanesan Dakshanamurthy   +2 more
doaj   +1 more source

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings

ImmunoInformatics, 2023
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated.
Runpeng Li, Prativa Sahoo, Dongrui Wang, Qixuan Wang, Christine E. Brown, Russell C. Rockne, Heyrim Cho   +6 more
doaj   +1 more source

Tools and data services registry: a community effort to document bioinformatics resources [PDF]

, 2015
Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment.
Anthon, Christian, Beard, Niall, Berka, Karel, Bolser, Dan, Booth, Tim, Bretaudeau, Anthony, Brezovsky, Jan, Brunak, Søren, Casadio, Rita, Cesareni, Gianni, Chmura, Piotr, Coppens, Frederik, Cornell, Michael, Cuccuru, Gianmauro, Davidsen, Kristian, de la Torre, Victor, Dogan, Tunca, Doppelt-Azeroual, Olivia, Emery, Laura, Friborg, Rune Møllegaard, Gasteiger, Elisabeth, Gatter, Thomas, Goldberg, Tatyana, Grosjean, Marie, Grüning, Björn, Helmer-Citterich, Manuela, Ienasescu, Hans, Ioannidis, Vassilios, Ison, Jon, Jespersen, Martin Closter, Jimenez, Rafael, Juty, Nick, Juvan, Peter, Kalaš, Matúš, Koch, Maximilian, Laibe, Camille, Li, Jing-Woei, Licata, Luana, Løngreen, Peter, Mareuil, Fabien, Mičetić, Ivan, Moretti, Sebastien, Morris, Chris, Ménager, Hervé, Möller, Steffen, Nenadic, Aleksandra, Parkinson, Helen, Peterson, Hedi, Profiti, Giuseppe, Rapacki, Kristoffer, Rice, Peter, Romano, Paolo, Roncaglia, Paola, Rost, Burkhard, Rydza, Emil, Saidi, Rabie, Schafferhans, Andrea, Schwämmle, Veit, Smith, Callum, Sperotto, Maria Maddalena, Stockinger, Heinz, Tosatto, Silvio C.E., Uva, Paolo, Vařeková, Radka Svobodová, Vedova, Gianluca Della, Via, Allegra, Vriend, Gert, Yachdav, Guy, Zambelli, Federico   +68 more
core   +15 more sources

Immunoinformatics and tick vaccinology

Exploration of Immunology, 2023
Immunoinformatics is an emerging area focused on development and applications of methods used to facilitate vaccine development. There is a growing interest in the field of vaccinology centered on the new omic science named ‘vaccinomics’. However, this approach has not succeeded to provide a solution against major infections affecting both animals and ...
Rodrigo Rosario-Cruz, Delia Inés Domínguez-García, Saúl López-Silva, Fernando Rosario-Domínguez   +3 more
openaire   +1 more source

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

Frontiers in Immunology
Ataxia-telangiectasia mutated (ATM) is traditionally recognized as a nuclear kinase involved in DNA damage repair. We were the first to report that ATM also participates in a manganese (Mn)-dependent TBK1 phosphorylation pathway.
Hongyan Sui, Rosana Wiscovitch-Russo, Silvia Cachaco, Silvia Cachaco, Jun Yang, Whitney Bruchey, Sylvain Laverdure, Qian Chen, Tomozumi Imamichi   +8 more
doaj   +1 more source

Simulating the decentralized processes of the human immune system in a virtual anatomy model [PDF]

, 2013
BACKGROUND: Many physiological processes within the human body can be perceived and modeled as large systems of interacting particles or swarming agents.
Christian Jacob, Vladimir Sarpe
core   +2 more sources

Immunoinformatics Comes of Age

PLoS Computational Biology, 2006
With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web interfaces.
Bette Korber, Montiago LaBute, Karina Yusim   +2 more
openaire   +4 more sources

AntigenDB: an immunoinformatics database of pathogen antigens [PDF]

Nucleic Acids Research, 2009
The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite.
Ansari, Hifzur R., Flower, Darren R, Raghava, G.P.S.   +2 more
openaire   +3 more sources

Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou, Chenbo Sun, Weitao Chen, Hanyu Gao, Fei Sun   +4 more
wiley   +2 more sources