Results 41 to 50 of about 8,611 (248)

Immunoinformatic Analysis of Human Thyroglobulin [PDF]

Cybernetics and Information Technologies, 2020
Abstract The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens, Thyroglobulin (Tg) and Thyroid PerOxidase (TPO).
Doytchinova Irini, Tchorbanov Andrey, Ivanov Stefan   +2 more
openaire   +2 more sources

Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the antiviral effect via different mechanisms in the individual cell-dependent manner

Frontiers in Immunology
IntroductionInterleukin (IL)-27 is an anti-viral cytokine. IL-27-treated monocyte-derived macrophages (27-Mac) suppressed HIV replication. Macrophages are generally divided into two subtypes, M1 and M2 macrophages.
Tomozumi Imamichi, Jun Yang, Qian Chen, Suranjana Goswami, Mayra Marquez, Udeshika Kariyawasam, Homa Nath Sharma, Rosana Wiscovitch-Russo, Xuan Li, Akihiro Aioi, Joseph W. Adelsberger, Weizhong Chang, Jeanette Higgins, Hongyan Sui   +13 more
doaj   +1 more source

CelltrackR: An R package for fast and flexible analysis of immune cell migration data

ImmunoInformatics, 2021
Visualization of cell migration via time-lapse microscopy has greatly advanced our understanding of the immune system. However, subtle differences in migration dynamics are easily obscured by biases and imaging artifacts.
Inge M.N. Wortel, Annie Y. Liu, Katharina Dannenberg, Jeffrey C. Berry, Mark J. Miller, Johannes Textor   +5 more
doaj   +1 more source

Deep learning for the detection of microsatellite instability from histology images in colorectal cancer: A systematic literature review

ImmunoInformatics, 2021
Microsatellite instability (MSI) or deficient mismatch repair (dMMR) is a clinically important genetic feature affecting 10–15% of colorectal cancer (CRC) patients.
Amelie Echle, Narmin Ghaffari Laleh, Peter L. Schrammen, Nicholas P. West, Christian Trautwein, Titus J. Brinker, Stephen B. Gruber, Roman D. Buelow, Peter Boor, Heike I. Grabsch, Philip Quirke, Jakob N. Kather   +11 more
doaj   +1 more source

Improving immunovirotherapies: the intersection of mathematical modelling and experiments

ImmunoInformatics, 2022
Combined oncolytic virotherapy and immunotherapy (immunovirotherapy) protocols represent a promising treatment strategy for a range of cancers and offer many advantages over conventional anti-cancer therapies.
Christine E. Engeland, Johannes P.W. Heidbuechel, Robyn P. Araujo, Adrianne L. Jenner   +3 more
doaj   +1 more source

Design of B‐Cell Multi‐Epitope Subunit Vaccines Against Glaesserella parasuis by Reverse Vaccinology: An In Silico and In Vivo Study

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Yan Gong, Na Li, Ziheng Li, He Wang, Di Zhang, Hong Chu, Zhichao Lu, Aiqing Jia, Fengyang Li, Liancheng Lei, Zhong Peng   +10 more
wiley   +1 more source

Allergenicity and oral tolerance of enzymatic cross-linked tropomyosin evaluated using cell and mouse models [PDF]

, 2017
The enzymatic cross-linking of proteins to form high-molecular-weight compounds may alter their sensitization potential. The IgG-/IgE-binding activity, digestibility, allergenicity, and oral tolerance of cross-linked tropomyosin with tyrosinase (CTC) or ...
Alcocer, Marcos J.C., Cao, Min-Jie, Fei, Dan-Xia, Han, Xin-Yu, Hu, Meng-Jun, Liu, Guang-Ming, Liu, Guang-Yu, Liu, Qing-Mei, Sun, Le-Chang   +8 more
core   +2 more sources

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

Advanced Science, Volume 12, Issue 45, December 4, 2025.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu, Lingyu Ke, Ruize Sun, Xiaoling Chen, Mei Zhou, Olaf R. P. Bininda‐Emond, Chengbang Ma, Yangyang Jiang, Tao Wang, Chris Shaw, Lei Wang, Tianbao Chen, Alideertu Dong   +12 more
wiley   +1 more source

Immune and bioinformatics identification of T cell and B cell epitopes in the protein structure of SARS-CoV-2: A systematic review [PDF]

, 2020
The beginning of 2020 was marked as the emergence of a COVID-19 outbreak caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Azizi, M., Kaffashian, M., Karami, C., Mami, S., Mirzaee, S. A., Noorimotlagh, Z.   +5 more
core   +1 more source

mRNA Cancer Vaccines: From Pandemic Paradigm to Personalized Oncology Therapeutics

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review highlights the transformative potential of mRNA cancer vaccines, leveraging technological advancements in nucleotide modification, lipid nanoparticle delivery, and AI‐driven neoantigen selection to enhance vaccine stability, immunogenicity, and personalization.
Bo Yang, Juan Liu, Yang Li, Xiaoxuan Liu
wiley   +1 more source