Results 41 to 50 of about 4,743 (216)

Epitopedia: identifying molecular mimicry between pathogens and known immune epitopes

ImmunoInformatics, 2023
Upon infection, foreign antigenic proteins stimulate the host's immune system to produce antibodies targeting the pathogen. These antibodies bind to regions on the antigen called epitopes.
Christian A Balbin, Janelle Nunez-Castilla, Vitalii Stebliankin, Prabin Baral, Masrur Sobhan, Trevor Cickovski, Ananda Mohan Mondal, Giri Narasimhan, Prem Chapagain, Kalai Mathee, Jessica Siltberg-Liberles   +10 more
doaj  

Scientometric Study of Mpox and Vaccine Research: Dynamics, Emerging Patterns, and Networking

Health Science Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background and Aim Mpox (Monkeypox) is a zoonotic disease transmitted through contact with infected animals or humans. Recent research focuses on epidemiology, transmission, and vaccine development to combat its resurgence. This bibliometric study analyzed the dynamics, emerging patterns, and networks of mpox and vaccine research from 2019 to ...
Fran Espinoza‐Carhuancho, Juan Alvitez, Abigail Temoche, Victor Roman‐Lazarte, Frank Mayta‐Tovalino   +4 more
wiley   +1 more source

Immunoinformatics: Current trends and future directions

Drug Discovery Today, 2009
Immunoinformatics has recently emerged as a critical field for accelerating immunology research. Although still an evolving process, computational models now play instrumental roles, not only in directing the selection of key experiments, but also in the formulation of new testable hypotheses through detailed analysis of complex immunologic data that ...
Joo Chuan Tong, Ee Chee Ren, Ee Chee Ren
openaire   +3 more sources

Benchmarking solutions to the T-cell receptor epitope prediction problem: IMMREP22 workshop report

ImmunoInformatics, 2023
Many different solutions to predicting the cognate epitope target of a T-cell receptor (TCR) have been proposed. However several questions on the advantages and disadvantages of these different approaches remain unresolved, as most methods have only been
Pieter Meysman, Justin Barton, Barbara Bravi, Liel Cohen-Lavi, Vadim Karnaukhov, Elias Lilleskov, Alessandro Montemurro, Morten Nielsen, Thierry Mora, Paul Pereira, Anna Postovskaya, María Rodríguez Martínez, Jorge Fernandez-de-Cossio-Diaz, Alexandra Vujkovic, Aleksandra M. Walczak, Anna Weber, Rose Yin, Anne Eugster, Virag Sharma   +18 more
doaj  

Nanobody engineering: computational modelling and design for biomedical and therapeutic applications

FEBS Open Bio, Volume 15, Issue 2, Page 236-253, February 2025.
This review focuses on structural characteristics, functional properties, and computational approaches driving the design and optimisation of synthetic nanobodies. We discuss recent advancements in computational methods for nanobody modelling, epitope prediction, and affinity maturation, shedding light on their intricate antigen‐binding mechanisms and ...
Nehad S. El Salamouni, Jordan H. Cater, Lisanne M. Spenkelink, Haibo Yu   +3 more
wiley   +1 more source

Machine-learning-based analytics for risk forecasting of anaphylaxis during general anesthesia

ImmunoInformatics, 2022
Perioperative anaphylaxis has a risk of mortality and compromised quality of patient care. It is difficult to design an evaluation system for risk of anaphylaxis using preoperative tests available in clinical practice.
Shuang Liu, Yasuyuki Suzuki, Toshihiro Yorozuya, Masaki Mogi   +3 more
doaj  

Mpox and Viral Co‐Infections: A Narrative Review

Health Science Reports, Volume 8, Issue 2, February 2025.
ABSTRACT Background and Aims Monkeypox (Mpox), caused by the monkeypox virus (MPXV), has emerged as a significant global public health concern, particularly following a substantial multi‐country outbreak in mid‐2022. The World Health Organization (WHO) reported 109,699 laboratory‐confirmed Mpox cases and 236 fatalities worldwide from January 1, 2022 ...
Mohsen Nakhaie, Mohammad Rezaei Zadeh Rukerd, Niloofar Farsiu, Davood Bashash, Fatemeh Khodadadpour Mahani, Nasir Arefinia, Javad Charostad, Mohammad Zarei, Farzane Behnezhad   +8 more
wiley   +1 more source

Chandipura Virus Resurgence in India: Insights Into Diagnostic Tools, Antiviral Development, and Public Health Implications

Global Health, Epidemiology and Genomics, Volume 2025, Issue 1, 2025.
Background: Chandipura virus (CHPV) is an emerging rhabdovirus primarily affecting pediatric populations in India, causing acute encephalitis syndrome (AES) with high mortality rates. First identified in 1965, CHPV has resurfaced in several outbreaks, the most recent being in 2024, with significant public health implications.
Adewunmi Akingbola, Abiodun Adegbesan, Kolade Adegoke, Joel Chuku, Olajide Ojo, Petra Mariaria, Uthman Alao, Raolat Adenike Salami, Michael Oladunjoye, Iqhrammullah Muhammad   +9 more
wiley   +1 more source

Structural pre-training improves physical accuracy of antibody structure prediction using deep learning.

ImmunoInformatics, 2023
Protein folding problem obtained a practical solution recently, owing to advances in deep learning. There are classes of proteins though, such as antibodies, that are structurally unique, where the general solution still lacks.
Jarosław Kończak, Bartosz Janusz, Jakub Młokosiewicz, Tadeusz Satława, Sonia Wróbel, Paweł Dudzic, Konrad Krawczyk   +6 more
doaj  

Designing and Evaluation of a Plasmid Encoding Immunogenic Epitopes From Echinococcus granulosus Eg95‐1‐6, P29, and GST Against Hydatid Cyst in BALB/c Mice

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Cystic echinococcosis (CE) is a neglected parasitic infection with a particular impact in humans and livestock. The current investigation was undertaken to design and evaluate a DNA vaccine encoding Echinococcus granulosus Eg95‐1 to EG95‐6, P29, and GST against hydatid cyst infection in BALB/c mice. Initially, B‐cell, cytotoxic T‐lymphocyte, and helper
Sasan Khazaei, Abdolhossein Dalimi, Majid Pirestani, Fatemeh Ghafarifar, Bernard Marchand   +4 more
wiley   +1 more source