Results 51 to 60 of about 4,743 (216)

Immunoinformatics: Implications on Reverse Vaccinology

Immunochemistry & Immunopathology, 2017
One area in which immunological studies have had most immediate and successful application is in the field of vaccination. Vaccines represent one of the greatest interventions in modern medicine [1]. Ever since Edward Jenner’s first use of a vaccine against smallpox in 1796, the use of vaccines has become indispensable to the eradication of disease [2].
openaire   +2 more sources

New algorithmic challenges of adaptive immune repertoire construction [PDF]

arXiv, 2016
Motivation: The analysis of antibodies and T-cell receptors (TCRs) concentrations in serum is a fundamental problem in immunoinformatics. Repertoire construction is a preliminary step of analysis of clonal lineages, understanding of immune response dynamics, population analysis of immunoglobulin and TCR loci.
arxiv  

Immunotherapeutic Approach for Improving the Efficacy of a Novel Subunit Vaccine Against SARS‐CoV‐2 by Cytotoxic T‐Lymphocytes (CTL) Epitopes

Scientifica, Volume 2025, Issue 1, 2025.
The present study aimed to employ a diverse range of immunoinformatics and in vitro techniques to construct and validate a potentially active multiepitope subunit vaccine against SARS‐CoV‐2 using cytotoxic T‐lymphocyte epitopes. To design the vaccine, a library of antigenic, nonallergic, and immunogenic epitopes of the spike protein was prepared.
Momina Javaid, Mahnoor Sagheer, Muhammad Zafar Saleem, Nazim Hussain, Nayla Munawar, Nidhi Chaudhary   +5 more
wiley   +1 more source

Progress Toward Antigenic Epitopes of African Swine Fever Virus and Their Identification

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
African swine fever virus (ASFV) is a highly contagious pathogen that causes pigs to develop high fever, vomiting, diarrhea, and respiratory distress, with an exceptionally high case fatality rate. Unfortunately, vaccine development is hindered by a limited understanding of the structure and function of the protein encoded by ASFV, as well as the ...
Xingjun Ke, Zhi Cao, Zhen Weng, Yin Xie, Fengyu Wu, Xinzhu Liu, Shiying Zhou, Mengjie Lian, Tongyu Liu, Ruize Sun, Lerong Ma, Aishi Xu, Jiaqi Wang, Hongsheng Ouyang, Linzhu Ren, Daxin Pang, Dongmei Lv, Nan-hua Chen   +17 more
wiley   +1 more source

Immunoinformatics and Computational Vaccinology: A Brief Introduction [PDF]

, 2007
Immunoinformatics has recently emerged as a buoyant and dynamic sub-discipline within the wider field of bioinformatics. Immunoinformatics is the application of bioinformatic methods to the unique problems of immunology and vaccinology. Immunoinformatics, as a principal component of incipient immunomic technologies, is beginning to foment important ...
Paul D. Taylor, Darren R. Flower
openaire   +1 more source

Molecular Analysis and Bioinformatics Assessment of Full‐Length L1 Gene of Bovine Papillomavirus Type‐1 as a Potential DNA Vaccine Study

Veterinary Medicine International, Volume 2025, Issue 1, 2025.
Background: Papillomaviruses (PVs) infect animals and humans and are linked to 27%–30% of cancers. The L1 protein is a cornerstone in bovine PVs (BPVs), being the main components of the viral capsid and playing pivotal roles in infectivity and antigenicity.
Hassan Hadi Abdul-Zahra, Yahia I. Khudhair, Husam Raheem Al-Hraishawi, Mahmoud Elhaig   +3 more
wiley   +1 more source

Association of pyroptosis and severeness of COVID-19 as revealed by integrated single-cell transcriptome data analysis

ImmunoInformatics, 2022
Cytokine storm and inflammatory cytokine release syndrome are often found to be associated with severe instances of the 2019 coronavirus disease (COVID-19). However, factors that contribute to the development of the COVID-19-associated cytokine storm and
Qian Xu, Yongjian Yang, Xiuren Zhang, James J. Cai   +3 more
doaj  

Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus

Cell Biochemistry and Function, Volume 42, Issue 8, December 2024.
ABSTRACT Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live‐attenuated vaccines. Challenges such as limited efficacy in low‐income regions, safety concerns for immunocompromised individuals, and cold‐chain dependency necessitate alternative vaccine strategies ...
Mukta Prajapati, Pooja Malik, Astha Sinha, Honey Yadav, Yachna K. Jaiwal, Yogesh K. Ahlawat, Darshna Chaudhary, Ranjana Jaiwal, Nisha Sharma, Pawan K. Jaiwal, Vijay K. Chattu   +10 more
wiley   +1 more source

Epitope identification of SARS-CoV-2 structural proteins using in silico approaches to obtain a conserved rational immunogenic peptide

ImmunoInformatics, 2022
The short time between the first cases of COVID-19 and the declaration of a pandemic initiated the search for ways to stop the spread of SARS-CoV-2. There are great expectations regarding the development of effective vaccines that protect against all ...
Leonardo Pereira de Araújo, Maria Eduarda Carvalho Dias, Gislaine Cristina Scodeler, Ana de Souza Santos, Letícia Martins Soares, Patrícia Paiva Corsetti, Ana Carolina Barbosa Padovan, Nelson José de Freitas Silveira, Leonardo Augusto de Almeida   +8 more
doaj  

An Integrated Approach to Develop a Potent Vaccine Candidate Construct Against Prostate Cancer by Utilizing Machine Learning and Bioinformatics

Cancer Reports, Volume 7, Issue 12, December 2024.
ABSTRACT Background Prostate cancer is the most common malignancy among males. Prostaglandin G/H synthase (PGHS) is an essential enzyme in the synthesis of prostaglandins, and its activation has been linked to many malignancies, including colorectal cancer.
Aqel Albutti
wiley   +1 more source