Results 61 to 70 of about 4,743 (216)

Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY [PDF]

Biomolecules, 2014
IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics.
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Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response

ImmunoInformatics, 2021
Response to cancer immunotherapies depends on the complex and dynamic interactions between T cell recognition and killing of cancer cells that are counteracted through immunosuppressive pathways in the tumor microenvironment.
Shuming Zhang, Chang Gong, Alvaro Ruiz-Martinez, Hanwen Wang, Emily Davis-Marcisak, Atul Deshpande, Aleksander S. Popel, Elana J. Fertig   +7 more
doaj  

Advancements in nanobody generation: Integrating conventional, in silico, and machine learning approaches

Biotechnology and Bioengineering, Volume 121, Issue 11, Page 3375-3388, November 2024.
Abstract Nanobodies, derived from camelids and sharks, offer compact, single‐variable heavy‐chain antibodies with diverse biomedical potential. This review explores their generation methods, including display techniques on phages, yeast, or bacteria, and computational methodologies.
D Jagadeeswara Reddy, Girijasankar Guntuku, Mary Sulakshana Palla   +2 more
wiley   +1 more source

IMGT-Choreography for immunogenetics and immunoinformatics.

In silico biology, 2005
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr), was created in 1989 at Montpellier, France. IMGT is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system ...
Lefranc, Marie-Paule, Clément, Olivier, Kaas, Quentin, Duprat, Elodie, Chastellan, Patrick, Coelho, Isabelle, Combres, Kora, Ginestoux, Chantal, Giudicelli, Véronique, Chaume, Denys, Lefranc, Gérard   +10 more
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Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination

ImmunoInformatics, 2021
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types.
Kamran Kaveh, Feng Fu
doaj  

Bioinformatics Analysis and Immunogenicity Assessment of the Novel Multi‐Stage DNA Vaccine W541 Against Mycobacterium Tuberculosis

Immunity, Inflammation and Disease, Volume 12, Issue 11, November 2024.
In this study, we construct the novel multi‐stage DNA vaccine, W541, against Mycobacterium tuberculosis. Then, bioinformatics methods were applied to analyze various physicochemical properties and immunological characteristics of the vaccine. Finally, the immunogenicity of the vaccine was evaluated in animal experiments.
Yourong Yang, Yong Xue, Xiaoou Wang, Lan Wang, Jie Wang, Junxian Zhang, Yinping Liu, Yan Liang, Xueqiong Wu   +8 more
wiley   +1 more source

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

ImmunoInformatics, 2022
The Omicron (BA.1/B.1.1.529) variant of SARS-CoV-2 harbors an alarming 37 mutations on its spike protein, reducing the efficacy of current COVID-19 vaccines. In this study, we identified CD8+ and CD4+ T cell epitopes from SARS-CoV-2 S protein mutants. To
Simone Parn, Kush Savsani, Sivanesan Dakshanamurthy   +2 more
doaj  

In silico vaccine design: A tutorial in immunoinformatics

Healthcare Analytics, 2022
Immunoinformatics, as a discipline, concerns the application of computational systems to study the immune system. Recently, the principles of reverse vaccinology have united with immunoinformatics to construct and evaluate novel vaccines in silico, enabling an economical response to emergent pathogens.
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Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings

ImmunoInformatics, 2023
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated.
Runpeng Li, Prativa Sahoo, Dongrui Wang, Qixuan Wang, Christine E. Brown, Russell C. Rockne, Heyrim Cho   +6 more
doaj  

IMGT-ONTOLOGY for immunogenetics and immunoinformatics.

In silico biology, 2004
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d ...
Lefranc, Marie-Paule, Giudicelli, Véronique, Ginestoux, Chantal, Bosc, Nathalie, Folch, Géraldine, Guiraudou, Delphine, Jabado-Michaloud, Joumana, Magris, Séverine, Scaviner, Dominique, Thouvenin, Valérie, Combres, Kora, Girod, David, Jeanjean, Stéphanie, Protat, Céline, Yousfi-Monod, Mehdi, Duprat, Elodie, Kaas, Quentin, Pommié, Christelle, Chaume, Denys, Lefranc, Gérard   +19 more
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