Results 71 to 80 of about 8,611 (248)

Computational Prediction of Broadly Neutralizing HIV-1 Antibody Epitopes from Neutralization Activity Data [PDF]

, 2013
Broadly neutralizing monoclonal antibodies effective against the majority of circulating isolates of HIV-1 have been isolated from a small number of infected individuals.
Burton, Dennis R., Chakraborty, Arup K., Falkowska, Emilia, Ferguson, Andrew L., Seaman, Michael S., Walker, Laura M.   +5 more
core   +6 more sources

Lessons learned from the IMMREP23 TCR-epitope prediction challenge

ImmunoInformatics
Here, we present the findings from IMMREP23, the second benchmark competition focused on predicting the specificity of TCR-pMHC interactions.The interaction of T cell receptors (TCR) towards their pMHC target is a cornerstone of the cellular immune ...
Morten Nielsen, Anne Eugster, Mathias Fynbo Jensen, Manisha Goel, Andreas Tiffeau-Mayer, Aurelien Pelissier, Sebastiaan Valkiers, María Rodríguez Martínez, Barthélémy Meynard-Piganeeau, Victor Greiff, Thierry Mora, Aleksandra M. Walczak, Giancarlo Croce, Dana L Moreno, David Gfeller, Pieter Meysman, Justin Barton   +16 more
doaj   +1 more source

Analysis of vitellogenin gene structure in Caspian roach, Rutilus caspicus (Pisces: Cyprinidae) during exposure to Atrazine [PDF]

, 2017
Chemical contamination of aquatic environments to EDCs has become a major focus of environmental toxicology research. The exposure of fishes to estrogenic EDCs in aquatic environments is most frequently assessed by analyzing Vitellogenin (Vg) (the egg ...
Behdani, M., Jamili, Sh., Mashinchian Moradi, A., Oveysi, M., Sharifpoor, E.   +4 more
core  

Survival analysis of DNA mutation motifs with penalized proportional hazards

, 2018
Antibodies, an essential part of our immune system, develop through an intricate process to bind a wide array of pathogens. This process involves randomly mutating DNA sequences encoding these antibodies to find variants with improved binding, though ...
Feng, Jean, Matsen IV, Frederick A., Minin, Vladimir N., Shaw, David A., Simon, Noah   +4 more
core   +2 more sources

A Comparison of Two Methods for T Cell Epitope Mapping: “Cell Free” In Vitro Versus Immunoinformatics [PDF]

, 2011
Background: Methods for identifying physiologically relevant T-cell epitopes are critically important for development of vaccines and the design of therapeutic proteins.
De Groot, Anne S., Martin, William, Messitt, Timothy J., Moise, Leonard, Terry, Frances   +4 more
core   +3 more sources

Epitope-Based Immunoinformatic Approach on Heat Shock 70 kDa Protein Complex of Cryptococcus neoformans var. grubii [PDF]

, 2021
Reham M. Elhassan, Nagla M. Alsony, Khadeejah M. Othman, Duaa T. Izz-Aldin, Tamadour A. Alhaj, Abdelrahman A. Ali, Lena A. Abashir, Omar Hashim Ahmed, Mohammed A. Hassan   +8 more
openalex   +1 more source

Data mining antibody sequences for database searching in bottom-up proteomics

ImmunoInformatics
Mass spectrometry-based proteomics facilitates the identification and quantification of thousands of proteins but encounters challenges in measuring human antibodies due to their vast diversity.
Xuan-Tung Trinh, Rebecca Freitag, Konrad Krawczyk, Veit Schwämmle   +3 more
doaj   +1 more source

Antigenic Protein Screening and Design of Multi‐Epitope Vaccine Against Lactococcus garvieri and Streptococcus iniae for Combating Lactococcosis and Streptococcosis in Fish

Veterinary Medicine and Science, Volume 11, Issue 4, July 2025.
The image depicts the computational identification of B cell epitopes from Lactococcus garvieae and Streptococcus iniae, leading to the design of an epitope‐based vaccine for fish. It features a stylised fish with the targeted bacteria and illustrates the process of identifying B cell epitopes using bioinformatics tools.
Ramesh Ranjbar, Abbas Doosti, Mostafa Shakhsi‐Niaei   +2 more
wiley   +1 more source

Immunoinformatics and Vaccine Development: An Overview.

ImmunoTargets and therapy, 2020
The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system.
Oli,Angus Nnamdi, Obialor,Wilson Okechukwu, Ifeanyichukwu,Martins Ositadimma, Odimegwu,Damian Chukwu, Okoyeh,Jude Nnaemeka, Emechebe,George Ogonna, Adejumo,Samson Adedeji, Ibeanu,Gordon C   +7 more
openaire   +3 more sources

The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences

ImmunoInformatics
The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinical platforms. Such analyses rely on comparing recombined TCR sequences to unrearranged germline reference
James M. Heather, Ayelet Peres, Gur Yaari, William Lees   +3 more
doaj   +1 more source