Results 71 to 80 of about 4,743 (216)

AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets

ImmunoInformatics, 2023
Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete ...
William D. Lees, Scott Christley, Ayelet Peres, Justin T. Kos, Brian Corrie, Duncan Ralph, Felix Breden, Lindsay G. Cowell, Gur Yaari, Martin Corcoran, Gunilla B. Karlsson Hedestam, Mats Ohlin, Andrew M. Collins, Corey T. Watson, Christian E. Busse   +14 more
doaj  

Interpretable deep learning to uncover the molecular binding patterns determining TCR–epitope interaction predictions

ImmunoInformatics, 2023
The recognition of an epitope by a T-cell receptor (TCR) is crucial for eliminating pathogens and establishing immunological memory. Prediction of the binding of any TCR–epitope pair is still a challenging task, especially for novel epitopes, because the
Ceder Dens, Wout Bittremieux, Fabio Affaticati, Kris Laukens, Pieter Meysman   +4 more
doaj  

Computational modelling of immunological mechanisms: From statistical approaches to interpretable machine learning

ImmunoInformatics, 2023
The immune system is highly complex, and its malfunctioning can result in many complex disorders. Understanding its inner workings is crucial to designing optimal immunotherapies, developing new vaccines, or understanding autoimmune diseases, just to ...
María Rodríguez Martínez, Matteo Barberis, Anna Niarakis   +2 more
doaj  

Prediction of Epitopes of Viral Antigens Recognized by Cytotoxic T Lymphocytes as an Immunoinformatics Approach to Anti-HIV/AIDS Vaccine Design [PDF]

, 2015
Andrew W. Taylor‐Robinson
openalex   +1 more source

Vaccines in silico: The growth and power of immunoinformatics [PDF]

The Biochemist, 2004
Immunoinformatics is a newly emergent subdiscipline within bioinformatics which deals with the special problems of immunology. It is rapidly establishing itself as a pivotal tool within vaccinology. This article shows how immunoinformatics complements, but does not replace, laboratory experimentation, allowing researchers to focus on key questions in ...
openaire   +1 more source

Lessons learned from the IMMREP23 TCR-epitope prediction challenge

ImmunoInformatics
Here, we present the findings from IMMREP23, the second benchmark competition focused on predicting the specificity of TCR-pMHC interactions.The interaction of T cell receptors (TCR) towards their pMHC target is a cornerstone of the cellular immune ...
Morten Nielsen, Anne Eugster, Mathias Fynbo Jensen, Manisha Goel, Andreas Tiffeau-Mayer, Aurelien Pelissier, Sebastiaan Valkiers, María Rodríguez Martínez, Barthélémy Meynard-Piganeeau, Victor Greiff, Thierry Mora, Aleksandra M. Walczak, Giancarlo Croce, Dana L Moreno, David Gfeller, Pieter Meysman, Justin Barton   +16 more
doaj  

Data mining antibody sequences for database searching in bottom-up proteomics

ImmunoInformatics
Mass spectrometry-based proteomics facilitates the identification and quantification of thousands of proteins but encounters challenges in measuring human antibodies due to their vast diversity.
Xuan-Tung Trinh, Rebecca Freitag, Konrad Krawczyk, Veit Schwämmle   +3 more
doaj  

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

ImmunoInformatics, 2022
T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified.
Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona   +10 more
doaj  

Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint

ImmunoInformatics, 2022
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes pain, swelling and stiffness in the joints, and negatively impacts the life of affected patients.
Fiona R. Macfarlane, Mark A.J. Chaplain, Raluca Eftimie   +2 more
doaj  

B and T-cell Epitopes Based Vaccine Design in Api m3 Allergen of Apis mellifera: An Immunoinformatics Approach [PDF]

, 2017
Nayem Zobayer, Abul Bashar Mohammad Hossain   +1 more
openalex   +1 more source