Results 31 to 40 of about 350,899 (304)

Molecular Endotypes (Type 1, 2, and 3) and Treatment Response in Chronic Rhinosinusitis: A Systematic Review of the Literature

Journal of Head & Neck Physicians and Surgeons
Introduction: Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder affecting the nasal and paranasal sinus mucosa for more than 12 weeks, with a significant global health impact.
Juan Pablo Alzate-Granados, Gloria Ibis Tirado Romero, Nicolas Zurek Duran, Laura Sanchez Campo, Maria Jose Diaz Gutierrez, Sandra Carolina Vega Rodriguez   +5 more
doaj   +1 more source

Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study

Clinical and Applied Thrombosis/Hemostasis, 2022
Background Thrombotic antiphospholipid syndrome (APS) is a systemic autoimmune disease; its diagnosis requires meeting both clinical and laboratory criteria.
Zhenzhen Su MM, Zhuochun Huang MD, Jiuliang Zhao MD, Mengtao Li MD, Jing Hu BS, Xiaofeng Zeng MD, Chaojun Hu PhD, Bin Yang PhD   +7 more
doaj   +1 more source

The Immunological Synapse [PDF]

Cancer Immunology Research, 2003
AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
openaire   +6 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Immunomodulatory Effect of Aza-Spirocyclic Frameworks

Frontiers in Bioscience-Landmark
Background: Immunomodulators play a central role in the treatment of cancer and immune-mediated disorders. Small-molecule immunomodulators are particularly attractive due to their structural diversity, pharmacological versatility, and ...
Anjali Prajapati, Rajitha Rajeshwar Tatikonda, Raji Reddy Chada, Srinivasa Reddy Bonam   +3 more
doaj   +1 more source

Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura

Biomédica: revista del Instituto Nacional de Salud, 2009
Los antiinflamatorios no esteroides son la segunda causa de reacciones a medicamentos después de los beta-lactámicos. La prevalencia de las reacciones a antiinflamatorios no esteroideos en la población general es de 0,1% a 0,3% y la prevalencia de ...
Ricardo Cardona, Ruth Helena Ramírez, Zulma Reina, Mauricio Fernando Escobar, Edison Morales   +4 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Comparative Efficacy of Topical Pomegranate Peel Extract and Topical Corticosteroid in Management of Oral Lichenoid Lesions: A Research Protocol

Journal of Clinical and Diagnostic Research
Introduction: Oral Lichenoid Lesions (OLL) represent a group of oral lesions that share common clinical features and histological appearances but have different aetiologies.
Suwarna Dangore-Khasbage, Rosalyn Lalremtluangi   +1 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Acceleration of Precision Medicine in Pediatric Rheumatic and Immunologic Diseases

, 2023
Rheumatic and immunologic diseases in children may involve multiple genes and interactions between genetic and environmental factors. There are no validated biomarkers that are predictive of treatment response.
SONG Hongmei, MA Mingsheng
core   +1 more source