Results 91 to 100 of about 125,515 (325)

Case Report: Aplastic anemia related to a novel CTLA4 variant

Frontiers in Pediatrics
A 20-year-old male patient with a history of celiac disease came to medical attention after developing profound fatigue and pancytopenia. Evaluation demonstrated pan-hypogammaglobulinemia. There was no history of significant clinical infections.
Geoffrey Hall, Janet G. Markle, James Maiarana, Paul L. Martin, Jennifer A. Rothman, John W. Sleasman, Howard Lederman, Antoine E. Azar, Robert A. Brodsky, Talal Mousallem   +9 more
doaj   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source

Adiponectin Assists Thrombopoietic Agents in ITP Treatment by Enhancing Myosin‐9/Rab6A‐Mediated Trafficking of c‐Mpl in MKs

Advanced Science, EarlyView.
This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao, Huixian Ma, Guosheng Li, Jilong Xiao, Zhiyu Shi, Mingying Li, Xinguang Liu, Tao Sun, Chunyan Ji   +8 more
wiley   +1 more source

tRF‐5004b Enriched Secretory Autophagosomes Induce Endothelial Cell Activation to Drive Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Acute respiratory distress syndrome (ARDS) is a severe lung condition with limited treatments, often triggered by overactive endothelial cells (ECs). It is identified that macrophage‐derived secretory autophagosomes (MSAPs) exacerbate lung damage by activating EC function.
Xing‐xing Zhu, Han Li, Shuang‐feng Zi, Ying Tang, Na Liu, Ke‐xin Li, Shi‐ke Geng, Hui‐qing Lu, Zhi‐kang Xie, Xin‐yi Xu, Yi‐ting Wei, Li‐xin Wang, Tao Liu, Jie Chao, Yi Yang, Hai‐bo Qiu, Wei Huang, Ling Liu   +17 more
wiley   +1 more source

Characterization of B Cell Responses in Rainbow Trout (Oncorhynchus Mykiss) Affected by Red Mark Syndrome

Advanced Science, EarlyView.
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado, Samuel Vicente‐Gil, Esther Morel, Pablo Jiménez‐Barrios, Rocío Simón, Pedro Perdiguero, Diana Martín, Marta Vargas‐Ramírez, Niels Lorenzen, Jacob Günther Schmidt, Carolina Tafalla   +10 more
wiley   +1 more source

HIV Controllers With Different Viral Load Cutoff Levels Have Distinct Virologic and Immunologic Profiles

Journal of Acquired Immune Deficiency Syndromes, 2015
F. H. Côrtes, C. P. Passaes, G. Bello, S. L. Teixeira, C. Vorsatz, Dunja Z. Babič, M. Sharkey, B. Grinsztejn, V. Veloso, M. Stevenson, M. Morgado   +10 more
semanticscholar   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches

Advanced Science, EarlyView.
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
wiley   +1 more source

The genetic basis of severe combined immunodeficiency and its variants

The Application of Clinical Genetics, 2012
Diana Tasher,1,2 Ilan Dalal1,21The Pediatric Infectious and Immunology Unit, E Wolfson Medical Center, Holon, Israel; 2The Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelAbstract: Severe combined immunodeficiency (SCID) syndromes are ...
Tasher D, Dalal I
doaj  

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source