Results 81 to 90 of about 125,515 (325)

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang   +14 more
wiley   +1 more source

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

open access: yesAdvanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan   +6 more
wiley   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

open access: yesAdvanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui   +6 more
wiley   +1 more source

Inmunodeficiencia primaria combinada: Presentación de un caso Combined primary inmunodeficiency: a case report

open access: yesRevista Cubana de Hematología, Inmunología y Hemoterapia, 2001
Se reporta el caso de un niño de 6 años de edad con infecciones respiratorias y digestivas recurrentes desde los 8 meses de edad. El estudio inmunológico reveló marcada disminución de la activación linfocitaria, niveles disminuidos de subclases de IgG2 ...
Vianed Marsán Suárez   +5 more
doaj  

Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression

open access: yesAdvanced Science, EarlyView.
GLed, a reversible lanthanide‐based GSH sensor that enables real‐time, single‐cell measurement of Gamma–Glutamyl Cysteine Ligase (GCL) activity ‐whose role in human T cells remains unclear‐ is developed. GLed directly links GCL activity to T cell effector functions and reveals its modulation by immunosuppressive drugs, identifying GCL as a critical ...
Francisco Fueyo‐González   +9 more
wiley   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

open access: yesAdvanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai   +5 more
wiley   +1 more source

Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy

open access: yesAdvanced Science, EarlyView.
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

open access: yesAdvanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan   +13 more
wiley   +1 more source

Challenging Physiotherapy for Children with Ataxia Telangiectasia

open access: yesFysioterapeuten, 2008
The aim of this article is to provide insight in the challenges for physiotherapists in assessment and treatment of the rare, degenerative and grave neurological disease Ataxia Telangiectasia (AT).
Ellen Velema, Trudy Burgers
doaj  

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