Results 21 to 30 of about 55,587 (208)

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

Blood Advances, 2017
: The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound.
Jean Kwun, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Alton B. Farris, Allan D. Kirk, Stuart J. Knechtle   +12 more
doaj   +1 more source

A practical view of immunotherapy for food allergy [PDF]

Korean Journal of Pediatrics, 2016
Food allergy is common and sometimes life threatening for Korean children. The current standard treatment of allergen avoidance and self-injectable epinephrine does not change the natural course of food allergy.
Tae Won Song
doaj   +1 more source

Immunological barriers in ABO-incompatible kidney transplantation: How to overcome

Indian Journal of Transplantation, 2019
Background: Various desensitization strategies are used to overcome immunologic barriers such as anti-human leukocyte antigen-donor-specific antibody (HLA-DSA) and anti-ABO blood group incompatibility.
Sonia Mehrotra, Raj Kumar Sharma
doaj   +1 more source

Immunotherapy in Allergic Fungal Sinusitis: The Controversy Continues. A Recent Review of Literature

Allergy & Rhinology, 2013
Allergic fungal sinusitis (AFS), also referred to as allergic fungal rhinosinusitis (AFRS), is a noninvasive, eosinophilic form of recurrent chronic allergic hypertrophic rhinosinusitis.
Mary S. Doellman D.O., Gregory R. Dion M.D., Erik Kent Weitzel M.D., Erika Gonzalez Reyes M.D.   +3 more
doaj   +1 more source

Sublingual immunotherapy (SLIT) – indications, mechanism, and efficacy Position paper prepared by the Section of Immunotherapy, Polish Society of Allergy

Annals of Agricultural and Environmental Medicine, 2015
SLIT ( sublingual immunotherapy ) induces allergen-specific immune tolerance by sublingual administration of a gradually increasing dose of an allergen.
Marek Jutel, Małgorzata Bartkowiak-Emeryk, Anna Bręborowicz, Ewa Cichocka-Jarosz, Andrzej Emeryk, Radosław Gawlik, Paweł Gonerko, Barbara Rogala, Anna Nowak-Węgrzyn, Bolesław Samoliński, and other members of IT Section PTA   +10 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Renal transplantation across the donor-specific antibody barrier: Graft outcome and cancer risk after desensitization therapy

, 2017
Background/Purpose: Desensitization regimens including use of intravenous immune globulin and rituximab have been reported to overcome renal transplant hyperacute rejection.
李志元;葉啟娟;楊卿堯;蔡孟昆, Yang, Ching-Yao;Lee, Chih-Yuan;Yeh, Chi-Chuan;Tsai, Meng-Kun   +1 more
core   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Longitudinal basophil activation testing for assessing response to low-dose initiation, slow-escalation peanut oral immunotherapy in patients with high Ara h 2-sIgE

Frontiers in Allergy
BackgroundPeanut oral immunotherapy (pOIT) can achieve desensitization, yet patients with high peanut-sIgE may experience more adverse reactions and treatment failure. We evaluated a conservative pOIT protocol in children with high Ara h 2-sIgE (≥40 kU/L)
Jinguo Chen, J. Joanna Yu, Jing Yu, Lili Wan, Lili Wan, Joseph Chiao, Athena Economides, Dingfen Han, H. Henry Li, H. Henry Li   +9 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source